Protein Overview: Gef26-PA

General Information:
Name(s) found:	Gef26-PA / FBpp0078879 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|90654483\|gb\|ABD96028.1\| Gef26 dizzy AI isoform [Drosophila melanogaster] [NCBI NR] gi\|24158429\|ref\|NP_609012.2\| Gef26, isoform A [Drosophila melanogaster] [NCBI NR] gi\|22945758\|gb\|AAF52365.2\| Gef26, isoform A [Drosophila melanogaster] [NCBI NR] gi\|165881869\|gb\|ABY71204.1\| dizzy isoform AII [Drosophila melanogaster] [NCBI NR] The gene Gef26 is referred to in FlyBase by the symbol Dmel\Gef26 (CG9491, FBgn0021873). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:6323767..6331552. It has the cytological map location 26C2-26C3. Based on sequence similarity, it is predicted to have molecular function</span>: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of developmental process; organ development; cellular component movement; cell projection organization; regulation of biological process; reproductive process in a multicellular organism; regulation of neurogenesis; regulation of compound eye photoreceptor development; regulation of cell morphogenesis; MAPKKK cascade; stem cell differentiation; sensory organ development; organ morphogenesis; imaginal disc-derived male genitalia development; multicellular organism reproduction. 22 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: organ system; external compound sense organ; adult segment; nervous system; adult mesothoracic segment; peripheral nervous system; embryonic nervous system; thoracic segment; hub cell; embryonic/larval hemocoel. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] >CG9491-PA translation from_gene[CG9491 dizzy FBgn0031798] seq_release:3 mol_weight=171725 cds_boundaries:(2L:6,317,483..6,322,855[+]) aa_length:1573 transcript_info:[CG9491-RA seq_release:3] gene_info:[gene symbol:dizzy FBgn0031798 gene_boundaries:(2L [hmr_yeast5_DM3-1_pombe.fasta] (Q9VMF3) CG9491 protein [DrosMelano7227.FASTAC.txt] CG9491-PA [Drosophila melanogaster]gi\|24158429\|ref\|NP_609012.2\| CG9491-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:join(6325268..6325297,6325357..6325602,6325713..6329487,6329548..6329697,6330123..6330643); ID=FBpp0078879; name=Gef26-PA; parent=FBgn0021873,FBtr0079249; dbxref=FlyBase:FBpp0078879,FlyBase_Annotation_IDs:CG9491-PA,GB_protein:AAF52365 [fly-100309-contam.fasta] Gef26 CG9491-PA [Drosophila melanogaster] [nr-271106-contam.fasta] Gef26 dizzy AI isoform [Drosophila melanogaster] [nr-271106-contam.fasta] CG9491-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:join(6325268..6325297,6325357..6325602,6325713..6329487,6329548..6329697,6330123..6330643); ID=FBpp0078879; name=Gef26-PA; parent=FBgn0021873,FBtr0079249; dbxref=FlyBase:FBpp0078879,FlyBase_Annotation_IDs:CG9491-PA,GB_protein:AAF52365.2,REFSEQ:NP_609012,GB_protein:AAF52365; MD5=c43d92eea947b31f5de918df8888cbb3; length=1573; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:join(6325268..6325297,6325357..6325602,6325713..6329487,6329548..6329697,6330123..6330643); ID=FBpp0078879; name=Gef26-PA; parent=FBgn0021873,FBtr0079249; dbxref=FlyBase:FBpp0078879,FlyBase_Annotation_IDs:CG9491-PA,GB_protein:AAF52365.2,REFSEQ:NP_609012,GB_protein:AAF52365; MD5=c43d92eea947b31f5de918df8888cbb3; length=1573; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Dizzy isoform AII OS=Drosophila melanogaster GN=Gef26 PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2L:join(6325268..6325297,6325357..6325602,6325713..6329487,6329548..6329697,6330123..6330643); ID=FBpp0078879; name=Gef26-PA; parent=FBgn0021873,FBtr0079249; dbxref=FlyBase:FBpp0078879,FlyBase_Annotation_IDs:CG9491-PA,GB_protein:AAF52365.2,REFSEQ:NP_609012,GB_protein:AAF52365,FlyMine:FBpp0078879,modMine:FBpp0078879; MD5=c43d92eea947b31f5de918df8888cbb3; length=1573; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:join(6325268..6325297,6325357..6325602,6325713..6329487,6329548..6329697,6330123..6330643); ID=FBpp0078879; name=PDZ-GEF-PA; parent=FBgn0265778,FBtr0079249; dbxref=FlyBase:FBpp0078879,FlyBase_Annotation_IDs:CG9491-PA,GB_protein:AAF52365.2,REFSEQ:NP_609012,GB_protein:AAF52365,FlyMine:FBpp0078879,modMine:FBpp0078879; MD5=c43d92eea947b31f5de918df8888cbb3; length=1573; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:join(6325268..6325297,6325357..6325602,6325713..6329487,6329548..6329697,6330123..6330643); ID=FBpp0078879; name=PDZ-GEF-PA; parent=FBgn0265778,FBtr0079249; dbxref=FlyBase:FBpp0078879,FlyBase_Annotation_IDs:CG9491-PA,GB_protein:AAF52365.2,REFSEQ:NP_609012,GB_protein:AAF52365,FlyMine:FBpp0078879,modMine:FBpp0078879; MD5=c43d92eea947b31f5de918df8888cbb3; length=1573; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Dizzy isoform AII OS=Drosophila melanogaster GN=PDZ-GEF PE=1 SV=2 [DROME.fasta.20160308] FBpp0078879 type=protein; loc=2L:join(6325268..6325297,6325357..6325602,6325713..6329487,6329548..6329697,6330123..6330643); ID=FBpp0078879; name=PDZ-GEF-PA; parent=FBgn0265778,FBtr0079249; dbxref=FlyBase:FBpp0078879,FlyBase_Annotation_IDs:CG9491-PA,GB_protein:AAF52365.2,REFSEQ:NP_609012,GB_protein:AAF52365,FlyMine:FBpp0078879,modMine:FBpp0078879; MD5=c43d92eea947b31f5de918df8888cbb3; length=1573; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:join(6325268..6325297,6325357..6325602,6325713..6329487,6329548..6329697,6330123..6330643); ID=FBpp0078879; name=PDZ-GEF-PA; parent=FBgn0265778,FBtr0079249; dbxref=FlyBase:FBpp0078879,FlyBase_Annotation_IDs:CG9491-PA,GB_protein:AAF52365.2,REFSEQ:NP_609012,GB_protein:AAF52365,UniProt/TrEMBL:Q9VMF3,FlyMine:FBpp0078879,modMine:FBpp0078879; MD5=c43d92eea947b31f5de918df8888cbb3; length=1573; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1573 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	hemocyte migration [IMP] MAPKKK cascade [IGI] oogenesis [IMP] regulation of small GTPase mediated signal transduction [IEA] germ-line stem cell maintenance [IMP] imaginal disc-derived wing morphogenesis [IMP] regulation of compound eye photoreceptor development [IMP] imaginal disc-derived male genitalia development [IMP] substrate-bound cell migration, cell extension [IMP] regulation of embryonic cell shape [IMP] compound eye development [IMP] axon target recognition [IMP]
Molecular Function:	protein binding [IEA] guanyl-nucleotide exchange factor activity [ISS][NAS] cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPYHHIRHH YPPTSIAGTG VVVGSSTTIN RPELHQKCNR GSHSSDTSSA YSGSDTMASN  60
   61 YASSLEAEEI DLSGLVESVV DSDEEDLAES MDSLTVRDAV RDCLEKDPAE RSEEDVEVLL 120
  121 EFTQGLKAFT NITLAVRRAL CSVMVFAVVD KAGTVVMSDG EELDSWSVLI NGAVEIEHAN 180
  181 GSREELQMGD SFGILPTMDK LYHRGVMRTK CDDCQFVCIT QTDYYRIQHQ GEENTRRHED 240
  241 ENGFVVMVTE LRSIGGAGTD SAGSGGSATG ASASLNMKRG HVVIRGTPER LLQQLVEENS 300
  301 MTDPTYVEDF LLTHRIFIQN PQEVTSKLLH WFDLEQVDAH KTQELRDRVT RVVLLWVNNH 360
  361 FTDFEADYEM MEFLEVFEAL LERKKLLSQL RLLHIACAAK ARMRSCTLTR SSRDEPLNFR 420
  421 IVGGYELRGV AIATGNAAVG IYISHVEPGS KAQDVGLKRG DQIHEVNGQS LDHVTSKRAL 480
  481 EILTGTTHLS ISVKSNLLGF KEIMQALEHG GGTAGSGSIS AGSGSFKSVR SPRRICANDI 540
  541 AKLHGRSDST TDELSSVSAS NRAHMVRLSS VDMLLDQPDC APPQTPPVSG SGNMASNFMQ 600
  601 QLLQSVNNSS AKKSGGNSNS DQQDTKGGFM TLAPKRRLQK ALAKMNLLNK QNHGSSLNDS 660
  661 SDTLLNDPKS KLSAVSSCSS STQSSINGCT VSGGGRLYQS QSNPDLTSLN YDGGSDAGGN 720
  721 GGGRLQVNYL NAHIHRPSAA STLTTNSTQS HLLPDYPDHV LKVYKADQTC KYVLIYKETT 780
  781 AHEVVMLTLQ EFGIHDPSSN FSLCEVSVGD GGMVKQRRLP DQLQNLAERI SFAARYYLKL 840
  841 NDSTEPLVPD ELALELVRES NVHFLHLNAY ELAIQLTLQD FANFRQIEST EYVDELFELR 900
  901 SRYGVPMLSK FAELVNREMF WVVSEICAEH NIVRRMKIVK QFIKIARHCK ECRNFNSMFA 960
  961 IVSGLGHGAV SRLRQTWEKL PSKYQRLFND LQDLMDPSRN MSKYRQLVSA ELLAQHPIIP1020
 1021 FYPIVKKDLT FIHLGNDTRV DGLINFEKLR MLAKEVRLLT HMCSSPYDLL SILELKGQSP1080
 1081 SNALFSLNQM SASQSNAAAG TVIAANAGQA TIKRRKKSTA APNPKKMFEE AQMVRRVKAY1140
 1141 LNSLKILSDE DLLHKFSLEC EPAHGSTYSG SISHGNTSHR SGGGGSISGG AGGSSGGGGG1200
 1201 GSSSLNAGDQ LSIYSHTSSS SAPNSSLSLR KRHPSSPTLS TTSSTSSTSD HQRRQMHNNG1260
 1261 PKFGTASPQA VKKMLSLSES SKIRPHQPFV PRHGSTMAGV IPPLHHMHAA HGFSTPSPGG1320
 1321 VVTSPATSAV ANVQCTPSPS PCSHRRLASG GNIIPSRAIH ERSHSDTPAP PPPLPSVDLS1380
 1381 LESSSVTTFR DLPLRKSVTS GSISSCDSGY VHQQQHYHLQ YQQQQQQNSS QHEPSPPVYT1440
 1441 AADCRLLQQI SNNAVTRNLN SPCQSTNTPP STPTPPPNQP TATIQLSAPP TAAAYMHARS1500
 1501 QHQQLQQQQQ SLAMPPPPPP PYNVPPLGSI YSHHQGTAGS RHLNHMHGKT TGPQERWFPD1560
 1561 CRPTTKQQMQ SGS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Protein Overview: Gef26-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: