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Protein Overview: U2af38-PA, FBpp0...

General Information:
Name(s) found: FBpp0305600 [FlyBase]
U2af38-PA / FBpp0077792 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=2L:complement(293622..294372,294441..294484); ID=FBpp0305600; name=U2af38-PB; parent=FBgn0017457,FBtr0333408; dbxref=REFSEQ:NP_001259814,GB_protein:AGB92351,FlyBase:FBpp0305600,FlyBase_Annotation_IDs:CG3582-PB; MD5=df11e82fa4d57097b20d30b586445e75; length=264; release=r5.56; species=Dmel; [FlyBase]
  • The gene U2 small nuclear riboprotein auxiliary factor 38 is referred to in FlyBase by the symbol Dmel\U2af38 (CG3582, FBgn0017457). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:293337..294679. It has the cytological map location 21B7-21B8. There is experimental evidence that it has the molecular function</span>: poly-pyrimidine tract binding. There is experimental evidence that it is involved in the biological process</span>: nuclear mRNA splicing, via spliceosome; mitotic spindle organization; regulation of alternative nuclear mRNA splicing, via spliceosome. 14 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; sex comb; crystal cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 264 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][NAS]
    precatalytic spliceosome [IDA]
    spliceosomal complex [ISS]
    U2 snRNP [NAS][TAS]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    mitotic spindle organization [IMP]
    nuclear mRNA splicing, via spliceosome [IC][IMP][ISS][NAS]
    Molecular Function: nucleotide binding [IEA]
    zinc ion binding [IEA]
    poly-pyrimidine tract binding [IDA][NAS]
    mRNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEYLASIFG TEKDKVNCSF YFKIGACRHG DRCSRIHNKP TFSQTVLLQN LYVNPQNSAK  60
   61 SADGSHLVAN VSDEEMQEHY DNFFEDVFVE CEDKYGEIEE MNVCDNLGDH LVGNVYIKFR 120
  121 NEADAEKAAN DLNNRWFGGR PVYSELSPVT DFREACCRQY EMGECTRSGF CNFMHLKPIS 180
  181 RELRRYLYSR RRRARSRSRS PGRRRGSRSR SRSPGRRGGG RGDGVGGGNY LNNERDNMRG 240
  241 NDRGNDRDRR KGGGGGGGGG GGRY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..160] PSI-BLAST 12.0 U2AF35 (35 KDa subunit)
    2 View Details [161..264] MSA 4.767997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.950788308762215 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.29562225149076 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle