Protein Overview: PTPRF_RAT

General Information:
Name(s) found:	PTPRF_RAT [Swiss-Prot]
Description(s) found: Found 14 descriptions. SHOW ALL	Receptor-type tyrosine-protein phosphatase F OS=Rattus norvegicus GN=Ptprf PE=2 SV=1 [Swiss-Prot]
Organism:	Rattus norvegicus
Length:	1898 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] growth cone [IDA] insoluble fraction [IDA] endosome [IDA] excitatory synapse [IDA] microsome [IDA] integral to membrane [IEA] neuronal cell body [IDA] neuron projection [IDA] plasma membrane [IDA]
Biological Process:	negative regulation of cell proliferation [IMP] protein amino acid dephosphorylation [IDA] nervous system development [IDA] cell adhesion [IEA] homophilic cell adhesion [IDA] negative regulation of epidermal growth factor receptor signaling pathway [IMP] negative regulation of insulin receptor signaling pathway [IMP] positive regulation of neuron apoptosis [IMP] negative regulation of cytokine-mediated signaling pathway [IMP] negative regulation of nerve growth factor receptor signaling pathway [IMP] positive regulation of apoptosis [IDA] regulation of synapse structure and activity [IMP] negative regulation of cell projection organization [IMP] positive regulation of dendrite morphogenesis [IMP]
Molecular Function:	protein tyrosine phosphatase activity [UNKNOWN][IDA][ISS] transmembrane receptor protein tyrosine phosphatase activity [IDA] receptor activity [IEA] insulin receptor binding [IDA] phosphate binding [IDA] receptor tyrosine kinase binding [IPI] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPEPAPGRR MVPLVPALVM LGLMAGAHGD SKPVFVKVPE DQIGLSGGVA SFVCQATGEP  60
   61 KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA 120
  121 KLSVLEEDQL PSGFPTIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPASS 180
  181 NGRIKQLRSG ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS 240
  241 QEVMPGGNVN LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV MRSANYTCVA 300
  301 ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNTEPVSFY GIQYRAAGTD 360
  361 GPFQEVDGVA STRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV 420
  421 QARMLSASTM LVQWEPPEEP NGLVRGYRVY YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP 480
  481 GITYSLRVLA FTAVGDGPPS PTIQVKTQQG VPAQPADFQA KAESDTRIQL SWLLPPQERI 540
  541 IKYELVYWAA EDEGQQHKVT FDPTSSYTLE DLKPDTLYHF QLAARSDLGV GVFTPTVEAC 600
  601 TAQSTPSAPP QKVTCVSTGS TTVRVSWVPP PADSRNGIIT QYSVAYEAVD GEDRKRHVVD 660
  661 GISREHSSWD LLGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL 720
  721 NSTAVHVSWK LPVPNKQHGQ IRGYQVTYVR LENGEPRGQP IIQDVMLAEA QETTISGLTP 780
  781 ETTYSITVAA YTTKGDGARS KPKVVTTTGA VPGRPTMMVS TTAMHTALLQ WHPPKELPGE 840
  841 LLGYRLQYRR ADEARPNTID FGKDDQHFTV TGLHKGATYI FRLAAKNRAG PGEEFEKEIT 900
  901 TPEDAPSGFP QNLRVTGLTT STTELAWDPP VLAERNGRIT NYTVVYRDIN SQHELQNVTG 960
  961 DVHLTLLGLK PDTTYDIKVR AHTSKGAGPL SPSIQSRTMP MEQVFAKNFR VAAAMKTSVL1020
 1021 LSWEVPDSYK SAVPFKILYN GQSVEVDGHS MRKLIADLQP NTEYSFVLMN RGTSAGGLQH1080
 1081 LVSIRTAPDL LPQKPLPASA FIEDGRFSLS MPQVQDPSLV RWFYIVVVPI DRVGGNLLAP1140
 1141 RWSTPEELEL DELLEAIEQG EEKQRRRRRQ AERLKPYVAA QVDELPETFT LGDKKNYRGF1200
 1201 YNRPLSPDLS YQCFVLASLK EPMDQKRYAS SPYSDEIVVQ VTPAQQQEEP EMLWVTGPVL1260
 1261 AVILIILIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH SSDPVEMRRL NYQTPGMRDH1320
 1321 PPIPITDLAD NIERLKANDG LKFSQEYESI DPGQQFTWEN SNSEVNKPKN RYANVIAYDH1380
 1381 SRVLLTSIDG VPGSDYINAN YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRIATVVMM1440
 1441 TRLEEKSRVK CDQYWPARGT ETYGLIQVTL VDTVELATYT MRTFALHKSG SSEKRELRQF1500
 1501 QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI VIDAMLERMK1560
 1561 HEKTVDIYGH VTCMRSQRNY MVQTEDQYVF IHEALLEAAM CGHTEVLARN LYAHIQKLGQ1620
 1621 VPPGESVTAM ELEFKLLAGS KARASRFISA NLPCNKFKNR LVNIMPYELT RVCLQPIRGV1680
 1681 EGSDYINASF LDGYRQQKAY IATQGPLAES TEDFWRMLWE HNSTIIVMLT KLREMGREKC1740
 1741 HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP1800
 1801 KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM RYEGVVDMFQ1860
 1861 TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: PTPRF_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: