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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Any process that modulates the frequency, rate or extent of a signaling pathway. The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity. Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of epidermal growth factor receptor signaling pathway
Acc: GO:0042059
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Synonyms:
  • downregulation of epidermal growth factor receptor signaling pathway
  • down-regulation of epidermal growth factor receptor signaling pathway
  • inhibition of epidermal growth factor receptor signaling pathway
  • negative regulation of EGF receptor signalling pathway
  • down regulation of epidermal growth factor receptor signaling pathway
  • negative regulation of EGF receptor signaling pathway
  • negative regulation of EGFR signaling pathway
Proteins in PDR annotated with:
   This term: 43 [Search]
   Term or descendants: 45 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042059 - negative regulation of epidermal growth factor receptor signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle