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Protein Overview: APEX1_RAT

General Information:
Name(s) found: APEX1_RAT [Swiss-Prot]
Description(s) found:
Found 26 descriptions.
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  • DNA-(apurinic or apyrimidinic site) lyase OS=Rattus norvegicus GN=Apex1 PE=1 SV=2 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 317 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA][ISS]
    transcription factor complex [IDA]
    centrosome [UNKNOWN]
    perinuclear region of cytoplasm [UNKNOWN][ISS]
    cytoplasm [UNKNOWN][IDA]
    mitochondrion [IDA]
    intracellular [IEA]
    nucleoplasm [UNKNOWN]
    Biological Process: DNA repair [NAS]
    regulation of DNA binding [UNKNOWN]
    positive regulation of S phase of mitotic cell cycle [IMP]
    response to drug [IEP]
    response to cAMP [IEP]
    negative regulation of smooth muscle cell migration [IMP]
    cell redox homeostasis [UNKNOWN][NAS]
    cellular response to hydrogen peroxide [IDA]
    aging [IDA]
    response to organic nitrogen [IEP]
    response to peptide hormone stimulus [IDA]
    Molecular Function: DNA binding [UNKNOWN][ISS]
    protein binding [UNKNOWN][IDA][IPI]
    transcription coactivator activity [UNKNOWN][ISS]
    oxidoreductase activity [UNKNOWN][ISS]
    transcription regulator activity [TAS]
    metal ion binding [UNKNOWN][ISS]
    endonuclease activity [UNKNOWN]
    lyase activity [IEA]
    DNA-(apurinic or apyrimidinic site) lyase activity [IEA]
    phosphoric diester hydrolase activity [UNKNOWN]
    protein complex binding [IPI]
    endoribonuclease activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKRGKRAAA EDGEEPKSEP ETKKSKGAAK KTEKEAAGEG PVLYEDPPDQ KTSASGKSAT  60
   61 LKICSWNVDG LRAWIKKKGL DWVKEEAPDI LCLQETKCSE NKLPAELQEL PGLTHQYWSA 120
  121 PSDKEGYSGV GLLSRQCPLK VSYGIGEEEH DQEGRVIVAE FESFILVTAY VPNAGRGLVR 180
  181 LEYRQRWDEA FRKFLKDLAS RKPLVLCGDL NVAHEEIDLR NPKGNKKNAG FTPQERQGFG 240
  241 EMLQAVPLAD SFRHLYPNTA YAYTFWTYMM NARSKNVGWR LDYFLLSHSL LPALCDSKIR 300
  301 SKALGSDHCP ITLYLAL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle