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Protein Overview: ITSN1_RAT

General Information:
Name(s) found: ITSN1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|9506823|ref|NP_062100.1| intersectin 1 isoform b [Rattus norvegicus] [NCBI NR]
  • gi|4835853|gb|AAD30271.1|AF127798_1 EH- and SH3-domain containing protein EHSH1 [Rattus norvegicus] [NCBI NR]
  • gi|20138462|sp|Q9WVE9.1|ITSN1_RAT RecName: Full=Intersectin-1; AltName: Full=EH domain and SH3 domain regulator of endocytosis 1 [NCBI NR]
  • Intersectin-1 OS=Rattus norvegicus GN=Itsn1 PE=1 SV=1 [Swiss-Prot]
  • (Q9WVE9) Intersectin 1 (EH domain and SH3 domain regulator of endocytosis 1) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):11-60702437;11-60690651 Splice isoform 1 of Q9WVE9 [hmr_yeast5_DM3-1_pombe.fasta]
  • intersectin 1; intersectin (SH3 domain protein 1A); intersection (SH3 domain protein 1A) [HMR_022704-rand.fasta]
  • Intersectin 1 (EH domain and SH3 domain regulator of endocytosis 1)gi|4835853|gb|AAD30271.1| EH- and SH3-domain containing protein EHSH1 [Rattus norvegicus] [nrdb_11152004_Chlamydomonas]
  • (NM_019227) intersectin 1; intersectin (SH3 domain protein 1A) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Intersectin-1 (EH domain and SH3 domain regulator of endocytosis 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • EH- and SH3-domain containing protein EHSH1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • intersectin 1 isoform b [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Itsn1 Isoform 1 of Intersectin-1 [rat-ipi-250309-contam.fasta]
  • Isoform 1 of Intersectin-1 OS=Rattus norvegicus GN=Itsn1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 1217 amino acids

    Gene Ontology:
    Cellular Component: endocytic vesicle [UNKNOWN]
    synaptosome [IEA]
    membrane [IEA]
    cytosol [UNKNOWN]
    endomembrane system [IEA]
    cell junction [IEA]
    synapse [IEA]
    intracellular [IEA]
    plasma membrane [UNKNOWN]
    lamellipodium [UNKNOWN][IEA]
    Biological Process: regulation of Rho protein signal transduction [IEA]
    small GTPase mediated signal transduction [UNKNOWN]
    apoptosis [UNKNOWN]
    endocytosis [IEA]
    exocytosis [TAS]
    induction of apoptosis by extracellular signals [UNKNOWN]
    positive regulation of protein kinase B signaling cascade [UNKNOWN]
    negative regulation of neuron apoptosis [UNKNOWN]
    Molecular Function: kinase activator activity [UNKNOWN]
    protein binding [UNKNOWN][IDA]
    calcium ion binding [IEA]
    guanyl-nucleotide exchange factor activity [UNKNOWN][IEA]
    Rho guanyl-nucleotide exchange factor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQFPTPFGG SLDIWAITVE ERAKHDQQFQ SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ  60
   61 IWALADMNKD GRMDQVEFSI AMKLIKLKLQ GYQLPPALPP VMKQQPAAIS SAPAFGIGGM 120
  121 AGMPPLTAVA PVPMGSIPVV GMSPPLVSSV PQAAVPPLAN GAPPVIQPLP AFAHPAATLP 180
  181 KSSSFSRSGP GSQLNTKLQK AQSFDVASAP AAAEWAVPQS SRLKYRQLFN SHDKTMSGHL 240
  241 TGPQARTILM QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 300
  301 PEYIPPSFRR VRSGSGMSVI SSSSADQRLP EEPSSEDEQQ VEKKLPVTFE DKKRENFERG 360
  361 NLELEKRRQA LLEQQRKEQE RLAQLERAEQ ERKERERQEQ ERKRQLELEK QLEKQRELER 420
  421 QREEERRKEI ERREAAKREL ERQRQLEWER NRRQELLTQR NKDQEGIVVL KARRKTLEFE 480
  481 LEALNDKKHQ LEGKLQDIRC RLATQRQEIE STNKSRELRI AEITHLQQQL QESQQMLGRL 540
  541 IPEKQILSDQ LKQVQQNSLH RDSLLTLKRA LEAKELARQQ LREQLDEVEK ETRSKLQEID 600
  601 VFNNQLKELR EIHSKQQLQK QRSIEAERLK QKEQERKSLE LEKQKEEGQR RVQERDKQWQ 660
  661 EHVQQEEQQR PRKPHEEDKL KREDSVKKKE AEERAKPEVQ DKQSRLFHPH QEPAKPAQAP 720
  721 WPTTEKGPLT ISAQESAKVV YYRALYPFES RSHDEITIQP GDIVMVKGEW VDESQTGEPG 780
  781 WLGGEPKGKT GWFPANYAEK IPENEIPTPA KPVTDLTSAP APKLALRETP APLPVTSSEP 840
  841 STTPNNWADF SSTWPSSTNE KPETDNWDTW AAQPSLTVPS AGQLRQRSAF TPATATGSSP 900
  901 SPVLGQGEKV EGLQAQALYP WRAKKDNHLN FNKSDVITVL EQQDMWWFGE VQGQKGWFPK 960
  961 SYVKLISGPV RKSTSIDTGP TEAPSSLKRV ASPAAKPAIP GEEFVAMYTY ESSEHGDLTF1020
 1021 QQGHVIVVTK KDGDWWTGTV GETSGVFPSN YVRLKDSEGS GTAGKTGSLE KKPEIAQVIA1080
 1081 SYTATGPEQL TLAPGQLILI RKKNPGGWWE GELQARGKKR QIGWFPANYV KLLSPGTSKI1140
 1141 TPTELPKTAV QPAVCQVIGM YDYTAQNDDE LAFSKGQIIN VLSKEDPDWW KGEVSGQVGL1200
 1201 FPSNYVKLTT DMDPSQQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle