Protein Overview: PGH1_RAT

General Information:
Name(s) found:	PGH1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|603052\|gb\|AAA85823.1\| prostaglandin H synthase [NCBI NR] gi\|3914292\|sp\|Q63921.2\|PGH1_RAT RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin-endoperoxide synthase 1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Sh [NCBI NR] pir\|\|S69198 prostaglandin G/H synthase 1 - rat [NCBI NR] Prostaglandin G/H synthase 1 OS=Rattus norvegicus GN=Ptgs1 PE=2 SV=2 [Swiss-Prot] Ensembl_locations(Chr-bp):3-15314015 Prostaglandin G/H synthase 1 precursor [hmr_yeast5_DM3-1_pombe.fasta] prostaglandin H synthasegi\|2143941\|pir\|\|S69198 prostaglandin G/H synthase 1 - ratgi\|3914292\|sp\|Q63921\|PGH1_RAT Prostaglandin G/H synthase 1 precursor (Cyclooxygenase -1) (COX-1) (Prostaglandin-endoperoxide synthase 1) (Prostaglandin H2 synthase 1) (PGH [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Prostaglandin G/H synthase 1 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Prostaglandin G/H synthase 1 precursor (Cyclooxygenase-1) (COX-1) (Prostaglandin-endoperoxide synthase 1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] prostaglandin H synthase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 PROSTAGLANDIN G/H SYNTHASE 1 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Ptgs1 Prostaglandin G/H synthase 1 [rat-ipi-250309-contam.fasta] Prostaglandin G/H synthase 1 OS=Rattus norvegicus GN=Ptgs1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	602 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [IDA] endoplasmic reticulum membrane [IEA] [NOT]nucleus [UNKNOWN][ISS] cytoplasm [UNKNOWN][IDA][ISS] microsome [UNKNOWN][ISS] endoplasmic reticulum [IEA] Golgi apparatus [UNKNOWN][IEA] plasma membrane [UNKNOWN][IEA]
Biological Process:	positive regulation of vasoconstriction [IMP] prostaglandin metabolic process [UNKNOWN] fatty acid biosynthetic process [IEA] aging [IEP] regulation of blood pressure [UNKNOWN][ISS] regulation of cell proliferation [UNKNOWN][IEA] positive regulation of smooth muscle contraction [IMP] response to oxidative stress [IEA] response to corticosterone stimulus [IEP] prostaglandin biosynthetic process [UNKNOWN][IMP][ISS][TAS] oxidation reduction [IEA] negative regulation of norepinephrine secretion [IMP] response to organic nitrogen [IEP] negative regulation of epinephrine secretion [IMP]
Molecular Function:	peroxidase activity [IEA] prostaglandin-endoperoxide synthase activity [TAS] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [IEA] oxidoreductase activity [IEA] metal ion binding [IEA] lipid binding [IMP] heme binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRRSLSLQF PLLLLLLLLP PPPVLLTDAG VPSPVNPCCY YPCQNQGVCV RFGLDHYQCD  60
   61 CTRTGYSGPN CTIPEIWTWL RSSLRPSPSF THFLLTHGYW IWEFVNATFI REVLMRLVIT 120
  121 VRSNLIPSPP TYNTAHDYIS WESFSNVSYY TRILPSVPKD CPTPMGTKGK KQLPDIHLLA 180
  181 QRLLLRREFI PGPQGTNVLF AFFAQHFTHQ FFKTSGKMGP GFTKALGHGV DLGHIYGDSL 240
  241 ERQYHLRLFK DGKLKYQVLD GEVYPPSVEQ ASVLMRYPPG VPPEKQMAVG QEVFGLLPGL 300
  301 MLFSTIWLRE HNRVCDLLKE EHPTWDDEQL FQTTRLILIG ETIKIIIEEY VQHLSGYFLQ 360
  361 LKFDPELLFR AQFQYRNRIA LEFNHLYHWH PLMPDSFQVG SQEYSYEQFL FNTSMLVDYG 420
  421 VEALVDAFSR QRAGRIGGGR NFDYHVLHVA EDVIKESREM RLQSFNEYRK RFGLKPYTSF 480
  481 QEFTGEKEMA AELEELYGDI DALEFYPGLM LEKCQPNSLF GESMIEMGAP FSLKGLLGNP 540
  541 ICSPEYWKPS TFGGDVGFNI VNTASLKKLV CLNTKTCPYV SFRVPDYPGD DGSVFVRPST 600
  601 EL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: PGH1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: