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Protein Overview: IKKB_RAT

General Information:
Name(s) found: IKKB_RAT [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Rattus norvegicus GN=Ikbkb PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 757 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [UNKNOWN][IDA]
    IkappaB kinase complex [IPI]
    membrane [IEA]
    membrane raft [IEA]
    microsome [IDA]
    cytosol [UNKNOWN]
    Biological Process: skeletal muscle contraction [IEP]
    anti-apoptosis [UNKNOWN]
    I-kappaB phosphorylation [IDA][IMP]
    response to drug [IEP]
    regulation of I-kappaB kinase/NF-kappaB cascade [IMP]
    protein amino acid phosphorylation [IEA]
    response to toxin [IEP]
    positive regulation of NF-kappaB transcription factor activity [UNKNOWN][IMP]
    B cell homeostasis [UNKNOWN][IEA]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IDA][IEA]
    identical protein binding [UNKNOWN][IEA]
    protein binding [UNKNOWN][IDA][IPI]
    protein heterodimerization activity [IPI]
    IkappaB kinase activity [IEA]
    protein kinase activity [UNKNOWN][IDA][IMP]
    protein serine/threonine kinase activity [IEA]
    transferase activity [IEA]
    kinase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQVTGEQ IAIKQCRQEL SPKNRDRWCL  60
   61 EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRRYLNQ FENCCGLREG 120
  121 AILTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEKRL IHKIIDLGYA KELDQGSLCT 180
  181 SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE 240
  241 VDIVVSEDLN GTVKFSSSSP FPNNLNSVLA ERLEKWLQLM LTWQPRQRGV DPQYGPNGCF 300
  301 RALDDILNLK LVHILNMVTG TIHTYPVMED ESLQSLKTRI REDTGILETD QELLQEAGLV 360
  361 LLPDKPATQC ISDSKTNEGL TLDMDLVFLF DNSKMSYETQ ITPRPQPESV SCVLQEPKRN 420
  421 LSFFQMRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMNLLR NNSCLSKMKN AMASTAQQLK 480
  481 AKLDFFKTSI QIDLEKYREQ TEFGITSDKL LLAWREMEQA VEQCGRENDV KVLVERMMAL 540
  541 QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQDM VRLLLQAIQS 600
  601 FEKKVRVIYS QLSKTVVCKQ KALELLPKVE EVVRLMNEDE KTVVRLQEKR QKELWNLLKI 660
  661 ACSKVRGPVS GSPDSMNVSR LSHPGHLMSQ PSSACDSLPD SDKKSEELVA EAHALCSRLE 720
  721 SALQDTVKQQ DRSFTTLDWS WLQMEDEERC GLEQACD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle