General Information: |
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Name(s) found: |
DNMT1_RAT
[Swiss-Prot]
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Description(s) found:
SHOW ONLY BEST |
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Organism: | Rattus norvegicus |
Length: | 1622 amino acids |
Gene Ontology: |
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Cellular Component: |
replication fork
[UNKNOWN]
heterochromatin [UNKNOWN] nucleus [UNKNOWN][IDA][IEA] protein complex [IDA] |
Biological Process: |
chromatin modification
[IEA]
S-adenosylmethioninamine metabolic process [IDA] S-adenosylmethionine metabolic process [IDA] regulation of transcription [IEA] regulation of cell proliferation [UNKNOWN] DNA methylation [UNKNOWN][IEA][TAS] negative regulation of transcription, DNA-dependent [UNKNOWN] S-adenosylhomocysteine metabolic process [IDA] negative regulation of histone H3-K9 methylation [UNKNOWN] positive regulation of gene expression [UNKNOWN] positive regulation of histone H3-K4 methylation [UNKNOWN] DNA methylation on cytosine within a CG sequence [IDA] regulation of gene expression [UNKNOWN] maintenance of DNA methylation [UNKNOWN][IDA] |
Molecular Function: |
zinc ion binding
[UNKNOWN][IEA]
protein domain specific binding [IPI] DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [IDA] double-stranded DNA binding [IDA] unmethylated CpG binding [IDA] transcription factor binding [IEA] S-adenosylmethionine-dependent methyltransferase activity [TAS] methyl-CpG binding [IDA] DNA-methyltransferase activity [UNKNOWN] DNA binding [UNKNOWN][IEA] DNA (cytosine-5-)-methyltransferase activity [UNKNOWN][IDA][IEA][IGI] protein binding [UNKNOWN][IPI] metal ion binding [IEA] transcription repressor activity [UNKNOWN] transferase activity [IEA] |
Sequence: |
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Sequence: [PDR BLAST] [ProtParam] |
1 11 21 31 41 51 | | | | | | 1 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ 60 61 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 120 121 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 180 181 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 240 241 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 300 301 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 360 361 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 420 421 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 480 481 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 540 541 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 600 601 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 660 661 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 720 721 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 780 781 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 840 841 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 900 901 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 960 961 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK1020 1021 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY1080 1081 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK1140 1141 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL1200 1201 KLVMAGEVTN SLGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN SLVVSFLSYC1260 1261 DYYRPRFFLL ENVRNFVSFR RSMVLKLTLR CLVRMGYQCT FGVLQAGQYG VAQTRRRAII1320 1321 LAAAPGEKLP LFPEPLHVFA PRACQLSVVV DDKKFVSNIT RLSSGPFRTI TMRDTMSDLP1380 1381 EIQNGASAPE ISYKWRATVL VPEAAARVAL PAHPQGPYPQ VHERAGGCRM RHIPLSPGSD1440 1441 WRDLPNIQVR LRDGVITNKL RYTFHDTKNG CSSTGALRGV CSCAEGKTCD PASRQFNTLI1500 1501 PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT VTNPEPMGKQ GRVLHPEQHR VVSVRECARS1560 1561 QGFPDTYRLF GNILDRHRQV GNAVPPPLAK AIGLEIKLCL LASAQESASA AVKGKEETTT1620 1621 ED |
NOT SHOWING SINGLE HITS. [ Show Single Hits ]
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Protein predicted to be: | GLOBULAR (No transmembrane regions or signal peptide) |
Confidence of classification: | 0.54 |
Source: Reynolds et al. (2008)