Protein Overview: DNMT1_RAT

General Information:
Name(s) found:	DNMT1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|20137608\|sp\|Q9Z330.2\|DNMT1_RAT RecName: Full=DNA (cytosine-5)-methyltransferase 1; Short=Dnmt1; AltName: Full=MCMT; AltName: Full=DNA methyltransferase I; AltName: Full=DNA MTase RnoIP; Short=M.RnoIP [NCBI NR] DNA (cytosine-5)-methyltransferase 1 OS=Rattus norvegicus GN=Dnmt1 PE=1 SV=2 [Swiss-Prot] (Q9Z330) DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase I) (DNA MTase RnoIP) (MCMT) (M.RnoIP) [Swiss-Prot] Ensembl_locations(Chr-bp):None Splice isoform 1 of Q9Z330 [hmr_yeast5_DM3-1_pombe.fasta] DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (DNA methyltransferase I) (DNA MTase RnoIP) (MCMT) (M.RnoIP) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform 1 of DNA [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (MCMT) (DNA methyltransferase I) (DNA MTase RnoIP) (M.RnoIP) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF DNA [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Dnmt1 Isoform 1 of DNA (cytosine-5)-methyltransferase 1 [rat-ipi-250309-contam.fasta] Isoform 1 of DNA (cytosine-5)-methyltransferase 1 OS=Rattus norvegicus GN=Dnmt1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1622 amino acids
Gene Ontology:
Cellular Component:	replication fork [UNKNOWN] heterochromatin [UNKNOWN] nucleus [UNKNOWN][IDA][IEA] protein complex [IDA]
Biological Process:	chromatin modification [IEA] S-adenosylmethioninamine metabolic process [IDA] S-adenosylmethionine metabolic process [IDA] regulation of transcription [IEA] regulation of cell proliferation [UNKNOWN] DNA methylation [UNKNOWN][IEA][TAS] negative regulation of transcription, DNA-dependent [UNKNOWN] S-adenosylhomocysteine metabolic process [IDA] negative regulation of histone H3-K9 methylation [UNKNOWN] positive regulation of gene expression [UNKNOWN] positive regulation of histone H3-K4 methylation [UNKNOWN] DNA methylation on cytosine within a CG sequence [IDA] regulation of gene expression [UNKNOWN] maintenance of DNA methylation [UNKNOWN][IDA]
Molecular Function:	zinc ion binding [UNKNOWN][IEA] protein domain specific binding [IPI] DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [IDA] double-stranded DNA binding [IDA] unmethylated CpG binding [IDA] transcription factor binding [IEA] S-adenosylmethionine-dependent methyltransferase activity [TAS] methyl-CpG binding [IDA] DNA-methyltransferase activity [UNKNOWN] DNA binding [UNKNOWN][IEA] DNA (cytosine-5-)-methyltransferase activity [UNKNOWN][IDA][IEA][IGI] protein binding [UNKNOWN][IPI] metal ion binding [IEA] transcription repressor activity [UNKNOWN] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVKEKLNLLH EFLQTEIKSQ  60
   61 LCDLETKLHK EELSEEGYLA KVKTLLNKDL CLENGTLSLT QKANGCPANG SRPTWKAEMA 120
  121 DSNRSPRSRP KPRGPRRSKS DSETMIEASS SSVATRRTTR QTTITSHFKG PAKRKPKEDS 180
  181 EKGNANESAA EERDQDKKRR VAGTESRASR AGESVEKPER VRPGTQLCQE EQGEQEDDRR 240
  241 PRRQTRELAS RRKSREDPDR EARPGTHLDV DDDDEKDKRS SRPRSQPRDL ATKRRPKEEV 300
  301 EQITPEPPEG KDEDEREEKR RKTTRKKPEP LSIPVQSRVE RKASQGKASA IPKLNPPQCP 360
  361 ECGQYLDDPD LKYQQHPVDA VDEPQMLTNE ALSVFDSNSS WFETYDSSPM HKFTFFSVYC 420
  421 SRGHLCPVDT GLIEKNVELY FSGVAKAIHE ENPSVEGGVN GKNLGPINQW WISGFDGGEK 480
  481 ALIGFSTAFA EYFLMEPSPE YAPIFGLMQE KIYISKIVVE FLQSNPDAVY EDLINKIETT 540
  541 VPPSAINVNR FTEDSLLRHA QFVVSQVESY DDAKDDDETP IFLSPCMRSL IHLAGVSLGQ 600
  601 RRATRRTVIN SAKVKRKGPT KATTTKLVYQ IFDTFFSEQI EKDDKEDKEN TMKRRRCGVC 660
  661 EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADEDEEAD DDIPELPSPK 720
  721 KLHQGKKKKQ NKDRISWLGE PVKIEENRTY YWKVSIDEET LEVGDCVSVI PDDPSKPLYL 780
  781 ARVTALWEDK NGQMFHAHWF CAGTDTVLGA TSDPLELFLV GECENMQLSY IHSKVKVIYR 840
  841 GPSPNWAMEG GMDPEAMLPG AEDGKTYFYQ FWYSQDYARF ESPPKTQPAE DNKHKFCLSC 900
  901 IRLAELRQKE MPKVLEQLEE VDGRVYCSSI TKNGVVYRLG DSVYLPPEAF TFNIKMASPM 960
  961 KRSKRDPVNE NPVPRDTYRK YSDYIKGSNL DAPEPYRIGR IKEIYCGKKK GGKVNEADIK1020
 1021 IRLYKFYRPE NTHKSIQATY HADINLLYWS DEEAVVDFSD VQGRCTVEYG EDLLESIQDY1080
 1081 SQGGPDRFYF LEAYNSKTKS FEDPPNHARS PGNKGKGKGK GKGKGKPQVS EPKEPEAAIK1140
 1141 LPKLRTLDVF SGCGGLTEGF HQAGISETLW AIEMWEPAAQ AFRLNNPGTT VFTEDCNVLL1200
 1201 KLVMAGEVTN SLGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN SLVVSFLSYC1260
 1261 DYYRPRFFLL ENVRNFVSFR RSMVLKLTLR CLVRMGYQCT FGVLQAGQYG VAQTRRRAII1320
 1321 LAAAPGEKLP LFPEPLHVFA PRACQLSVVV DDKKFVSNIT RLSSGPFRTI TMRDTMSDLP1380
 1381 EIQNGASAPE ISYKWRATVL VPEAAARVAL PAHPQGPYPQ VHERAGGCRM RHIPLSPGSD1440
 1441 WRDLPNIQVR LRDGVITNKL RYTFHDTKNG CSSTGALRGV CSCAEGKTCD PASRQFNTLI1500
 1501 PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT VTNPEPMGKQ GRVLHPEQHR VVSVRECARS1560
 1561 QGFPDTYRLF GNILDRHRQV GNAVPPPLAK AIGLEIKLCL LASAQESASA AVKGKEETTT1620
 1621 ED

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.54

Protein Overview: DNMT1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: