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Protein Overview: PHB_RAT

General Information:
Name(s) found: PHB_RAT [Swiss-Prot]
Description(s) found:
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  • pir||A39682 prohibitin - rat [NCBI NR]
  • gi|66911717|gb|AAH97304.1| Prohibitin [Rattus norvegicus] [NCBI NR]
  • gi|54038835|sp|P67779.1|PHB_RAT RecName: Full=Prohibitin [NCBI NR]
  • gi|47939880|gb|AAH72518.1| Prohibitin [Rattus norvegicus] [NCBI NR]
  • gi|206384|gb|AAA63500.1| prohibitin [NCBI NR]
  • gi|149053945|gb|EDM05762.1| rCG35301, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149053944|gb|EDM05761.1| rCG35301, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|13937353|ref|NP_114039.1| prohibitin [Rattus norvegicus] [NCBI NR]
  • gi|109490241|ref|XP_001053031.1| PREDICTED: prohibitin [Rattus norvegicus] [NCBI NR]
  • Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):6-135562378 Prohibitin [hmr_yeast5_DM3-1_pombe.fasta]
  • prohibitin [HMR_022704-rand.fasta]
  • prohibitin [Mus musculus]gi|54035592|gb|AAH83354.1| Prohibitin [Mus musculus]gi|13937353|ref|NP_114039.1| prohibitin [Rattus norvegicus]gi|47939880|gb|AAH72518.1| Prohibitin [Rattus norvegicus]gi|541732|emb|CAA55349.1| prohibitin or B-cell receptor as [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Prohibitin [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_031851) prohibitin [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • prohibitin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Prohibitin [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • rCG35301, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • PREDICTED: prohibitin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Prohibitin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 PROHIBITIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Phb Prohibitin [rat-ipi-250309-contam.fasta]
  • Prohibitin OS=Rattus norvegicus GN=Phb [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 272 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    integral to plasma membrane [UNKNOWN]
    cytoplasm [IDA]
    mitochondrial crista [IDA]
    mitochondrion [UNKNOWN][IDA]
    membrane [IEA]
    extrinsic to mitochondrial outer membrane [IDA]
    mitochondrial inner membrane [UNKNOWN]
    nucleoplasm [UNKNOWN]
    Biological Process: response to cytokine stimulus [IEP]
    DNA replication [IEA]
    negative regulation of cell proliferation [IMP]
    regulation of transcription [UNKNOWN]
    response to peptide hormone stimulus [IEP]
    response to stress [IEP]
    ovarian follicle development [IEP]
    ovarian follicle atresia [IEP]
    response to ethanol [IEP]
    negative regulation of transcription [UNKNOWN]
    response to drug [IEP]
    negative regulation of apoptosis [IMP]
    organ regeneration [IEP]
    histone deacetylation [UNKNOWN]
    Molecular Function: protein binding [UNKNOWN]
    transcription activator activity [UNKNOWN]
    transcription repressor activity [UNKNOWN]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW  60
   61 VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIYTSI GEDYDERVLP 120
  121 SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT 180
  181 EAVEAKQVAQ QEAERARFVV EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK 240
  241 LEAAEDIAYQ LSRSRNITYL PAGQSVLLQL PQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..197] PSI-BLAST 11.39794 Solution Structure of the Band 7 Domain of the mouse Flotillin 2 Protein
    2 View Details [198..272] MSA 2.611996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.10215477176861 bayes_pls_golite062009
  • protein binding
    		•  0.769979871341236 bayes_pls_golite062009
  • structural molecule activity
    		•  0.591437172549816 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle