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Protein Overview: PLCG2_RAT

General Information:
Name(s) found: PLCG2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|8393984|ref|NP_058864.1| phospholipase C, gamma 2 [Rattus norvegicus] [NCBI NR]
  • gi|206243|gb|AAA41896.1| phospholipase C type IV (PLP IV) [NCBI NR]
  • gi|130230|sp|P24135.1|PLCG2_RAT RecName: Full=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; AltName: Full=Phosphoinositide phospholipase C; AltName: Full=Phospholipase C-gamma-2; Short=PLC-gamma-2; AltName: Full=PLC-IV [NCBI NR]
  • pir||A34163 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase (EC 3.1.4.11) - rat [NCBI NR]
  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Rattus norvegicus GN=Plcg2 PE=1 SV=1 [Swiss-Prot]
  • (P24135) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):19-45672054;19-45672054 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • phospholipase C, gamma 2 [HMR_022704-rand.fasta]
  • phospholipase C, gamma 2 [Rattus norvegicus]gi|130230|sp|P24135|PIG2_RAT 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV)gi|111280|pir||A34163 1-phospha [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_017168) phospholipase C, gamma 2 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (Phosphoinositide phospholipase C) (Phospholipase C-gamma-2) (PLC-gamma-2) (PLC-IV) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • phospholipase C, gamma 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • phospholipase C type IV (PLP IV) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Plcg2 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 [rat-ipi-250309-contam.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 OS=Rattus norvegicus GN=Plcg2 [011711_HMR.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 OS=Rattus norvegicus GN=Plcg2 PE=1 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 1265 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDA]
    plasma membrane [UNKNOWN]
    Biological Process: signal transduction [IEA]
    response to ATP [IDA]
    phospholipid catabolic process [IEA]
    negative regulation of programmed cell death [UNKNOWN][IEA]
    elevation of cytosolic calcium ion concentration [IMP]
    follicular B cell differentiation [UNKNOWN][IEA]
    inositol trisphosphate biosynthetic process [UNKNOWN][IEA]
    lipid catabolic process [IEA]
    regulation of gene expression [UNKNOWN][IEA]
    response to magnesium ion [IDA]
    response to lipopolysaccharide [UNKNOWN][IEA]
    T cell receptor signaling pathway [UNKNOWN][IEA]
    activation of store-operated calcium channel activity [UNKNOWN][IEA]
    Molecular Function: phosphoinositide phospholipase C activity [IDA]
    protein binding [UNKNOWN][IPI]
    phospholipase C activity [UNKNOWN]
    signal transducer activity [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTMVNVDTL PEYEKSQIKR ALELGTVMTV FSARKSTPER RTVQMIMETR QVAWSKTADK  60
   61 IEGFLDIMEI KEIRPGKNSK DFERAKAVRH KADCCFTIFY GTQFVLSTLS LATDSKEDAV 120
  121 KWLSGLKILH QEAMNASTPT MIESWLRKQI YSVDQTRRNS ISLRELKTIL PLVNFKVSGI 180
  181 KFLKDKLVEI GAQKDELSFE QFHLFYKKLM FEQQKSILDE FKKDSSVFIL GNTDRPDASA 240
  241 VYLQDFQRFL LHEQQELWAQ DLNKVRERMT KFIDDTMRET AEPFLFVDEF LTYLFSRENS 300
  301 IWDEKYDAVD MQDMNNPLSH YWISSSHNTY LTGDQLRSES STEAYIRCLR AGCRCIELDC 360
  361 WDGPDGKPII YHGWTRTTKI KFDDVVQAIR DHAFVTSSFP VILSIEEHCS VEQQRHMAKV 420
  421 FKEVLGDLLL TKPTEASADQ LPSPSQLREK IIIKHKKLGP RGDVDVNVED KKDEHKTQGE 480
  481 LYMWDSIDQK WTRHYCAIAD AKLSFSDDIE QTVEEDPVQD TPPTELHFGE KWFHKKVESR 540
  541 TSAEKLLQEY CAETGAKDGT FLVRESETFP NDYTLSFWRS GRVQHCRIRS TMEGGVMKYY 600
  601 LTDNLTFNSI YALIQHYREA HLRCAEFELR LTDPVPNPNP HESKPWYYDR LSRGEAEDML 660
  661 MRIPRDGAFL IRKREGTDSY AITFRARGKV KHCRINRDGR HFVLGTSAYF ESLVELVSYY 720
  721 EKHALYRKMR LRYPVTPELL ERYNMERDIN SLYDVSRMYV DPSEINPSMP QRTVKALYDY 780
  781 KAKRSDELTF CRGALIHNVS KEPGGWWKGD YGTRIQQYFP SNYVEDISAG DAEEMEKQII 840
  841 EDNPLGSLCR GILDLNTYNV VKAPQGKNQK AFVFILEPKK QGDPPVEFAT DRVEELFEWF 900
  901 QSIREITWKI DTKENNMKYW ERNQSIAIEL SDLVVYCKPT SKTKDHLENP DFREIRSFVE 960
  961 TKADSIVRQK PVDLLRYNQK GLTRVYPKGQ RVDSSNYDPF RLWLCGSQMV ALNFQTPDKY1020
 1021 MQMNHALFSL NGRTGYVLQP ESMRSEKYDP MPPESQRKIL MTLTVKVLGA RHLPKLGRSI1080
 1081 ACPFVEVEIC GAEYDSNKFK TTVVNDNGLS PVWAPTQEKV TFEIYDPNLA FLRFLVYEED1140
 1141 MFSDPNFLAH ATYPIKGIKS GFRSVPLKNG YSEDIELASL LVFCEMRPVL ESEEELYSSC1200
 1201 RQLRRRQEEL NNQLFLYDTH QNLRGANRDA LVKEFNVNEN QLRLYQEKCN RRLREKRVSN1260
 1261 SRFYS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle