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Protein Overview: DUS6_RAT

General Information:
Name(s) found: DUS6_RAT [Swiss-Prot]
Description(s) found:
Found 22 descriptions.
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  • Dual specificity protein phosphatase 6 OS=Rattus norvegicus GN=Dusp6 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 381 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [UNKNOWN][IDA]
    nucleoplasm [UNKNOWN]
    Biological Process: inactivation of MAPK activity [UNKNOWN][IEA]
    regulation of heart growth [UNKNOWN]
    response to growth factor stimulus [IEP]
    negative regulation of protein amino acid phosphorylation [UNKNOWN]
    response to drug [IEP]
    negative regulation of ERK1 and ERK2 cascade [UNKNOWN][IDA]
    protein amino acid dephosphorylation [UNKNOWN][IEA]
    positive regulation of apoptosis [UNKNOWN]
    cell differentiation [IEP]
    response to nitrosative stress [UNKNOWN]
    response to organic cyclic substance [IEP]
    Molecular Function: protein serine/threonine phosphatase activity [IEA]
    phosphoprotein phosphatase activity [UNKNOWN]
    protein binding [UNKNOWN][IEA]
    protein tyrosine phosphatase activity [UNKNOWN][IEA]
    MAP kinase tyrosine/serine/threonine phosphatase activity [UNKNOWN][IEA]
    protein tyrosine/serine/threonine phosphatase activity [IDA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIDTLRPVPF ASEMAISKTV AWLNEQLELG NEQLLLMDCR PQELYESSHI ESAINVAIPG  60
   61 IMLRRLQKGN LPVRALFTRC EDRDRFTRRC GTDTVVLYDE NSSDWNENTG GESVLGLLLK 120
  121 KLKDEGCRAF YLEGGFSKFQ AEFALHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI 180
  181 ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT 240
  241 PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS 300
  301 VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ 360
  361 QLYFTAPSNQ NVYQVDSLQS T

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle