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Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases. Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of ERK1 and ERK2 cascade
Acc: GO:0070373
Aspect: Biological Process
Desc: Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
Synonyms:
  • negative regulation of ERK1 cascade
  • down regulation of ERK1 and ERK2 cascade
  • negative regulation of MAPK1 cascade
  • inhibition of ERK1 and ERK2 cascade
  • downregulation of ERK1 and ERK2 cascade
  • negative regulation of ERK cascade
  • negative regulation of ERK1/2 cascade
  • negative regulation of ERK1 and ERK2 signaling pathway
  • negative regulation of ERK1 and ERK2 signalling pathway
  • negative regulation of ERK2 cascade
  • negative regulation of MAPK3 cascade
  • down-regulation of ERK1 and ERK2 cascade
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 14 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070373 - negative regulation of ERK1 and ERK2 cascade (interactive image map)
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