Protein Overview: NOTC2_RAT

General Information:
Name(s) found:	NOTC2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|A49128 cell-fate determining gene Notch2 protein - rat [NCBI NR] gi\|20138817\|sp\|Q9QW30.1\|NOTC2_RAT RecName: Full=Neurogenic locus notch homolog protein 2; Short=Notch 2; Contains: RecName: Full=Notch 2 extracellular truncation; Contains: RecName: Full=Notch 2 intracellular domain; Flags: Precursor [NCBI NR] gi\|13242247\|ref\|NP_077334.1\| Notch homolog 2 [Rattus norvegicus] [NCBI NR] gi\|13162674\|gb\|AAK13558.1\| NOTCH2 [Rattus norvegicus] [NCBI NR] (Q9QW30) Neurogenic locus notch homolog protein 2 precursor (Notch 2) [Swiss-Prot] Neurogenic locus notch homolog protein 2 OS=Rattus norvegicus GN=Notch2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):2-188032407 Neurogenic locus notch homolog protein 2 precursor [hmr_yeast5_DM3-1_pombe.fasta] notch gene homolog 2,; notch gene homolog 2 (Drosophila) [HMR_022704-rand.fasta] notch gene homolog 2 [071204_hmrz_cont.fasta] notch gene homolog 2 [Rattus norvegicus]gi\|13162674\|gb\|AAK13558.1\| NOTCH2 [Rattus norvegicus]gi\|477495\|pir\|\|A49128 cell-fate determining gene Notch2 protein - ratgi\|20138817\|sp\|Q9QW30\|NTC2_RAT Neurogenic locus notch homolog protein 2 precursor (Notch 2 [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Neurogenic locus notch homolog protein 2 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_024358) Notch gene homolog 2; Notch gene homolog 2, (Drosophila) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Neurogenic locus notch homolog protein 2 precursor (Notch 2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] notch gene homolog 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] NOTCH2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Notch homolog 2 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Notch2 Neurogenic locus notch homolog protein 2 [rat-ipi-250309-contam.fasta] neurogenic locus notch homolog protein 2 precursor [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Neurogenic locus notch homolog protein 2 OS=Rattus norvegicus GN=Notch2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	2471 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][ISS] integral to plasma membrane [UNKNOWN][ISS] membrane [IEA] integral to membrane [IEA] plasma membrane [IEA] cell surface [UNKNOWN][ISS][TAS]
Biological Process:	cell cycle arrest [UNKNOWN][ISS] multicellular organismal development [IEA] negative regulation of cell proliferation [UNKNOWN][ISS] positive regulation of Ras protein signal transduction [UNKNOWN][ISS] morphogenesis of an epithelial sheet [UNKNOWN][IEA] tissue regeneration [IEP] regulation of transcription [IEA] determination of left/right symmetry [UNKNOWN][IEA] organ morphogenesis [UNKNOWN][ISS] embryonic limb morphogenesis [UNKNOWN][IEA] regulation of developmental process [IEA] Notch signaling pathway [IEA] positive regulation of apoptosis [UNKNOWN][IEA] cell differentiation [IEA] cell fate determination [IDA] cell growth [UNKNOWN][ISS]
Molecular Function:	protein binding [UNKNOWN][IDA] calcium ion binding [IEA] receptor activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPALRPAALR ALLWLWLCGA GPAHALQCRG GQEPCVNEGT CVTYHNGTGY CRCPEGFLGE  60
   61 YCQHRDPCEK NRCQNGGTCV TQAMLGKATC RCAPGFTGED CQYSTSHPCF VSRPCQNGGT 120
  121 CHMLSWDTYE CTCQVGFTGK QCQWTDVCLS HPCENGSTCS SVANQFSCRC PAGITGQKCD 180
  181 ADINECDIPG RCQHGGTCLN LPGSYRCQCP QRFTGQHCDS PYVPCAPSPC VNGGTCRQTG 240
  241 DFTSECHCLP GFEGSNCERN IDDCPNHKCQ NGGVCVDGVN TYNCRCPPQW TGQFCTEDVD 300
  301 ECLLQPNACQ NGGTCTNRNG GYGCVCVNGW SGDDCSENID DCAFASCTPG STCIDRVASF 360
  361 SCLCPEGKAG LLCHLDDACI SNPCHKGALC DTNPLNGQYI CTCPQAYKGA DCTEDVDECA 420
  421 MANSNPCEHA GKCVNTDGAF HCECLKGYAG PRCEMDINEC HSDPCQNDAT CLDKIGGFTC 480
  481 LCMPGFKGVH CELEVNECQS NPCVNNGQCV DKVNRFQCLC PPGFTGPVCQ IDIDDCSSTP 540
  541 CLNGAKCIDH PNGYECQCAT GFTGTLCDEN IDNCDPDPCH HGQCQDGIDS YTCICNPGYM 600
  601 GAICSDQIDE CYSSPCLNDG RCIDLVNGYQ CNCQPGTSGL NCEINFDDCA SNPCLHGACV 660
  661 DGINRYSCVC SPGFTGQRCN IDIDECASNP CRKDATCIND VNGFRCMCPE GPHHPSCYSQ 720
  721 VNECLSSPCI HGNCTGGLSG YKCLCDAGWV GINCEVDKNE CLSNPCQNGG TCNNLVNGYR 780
  781 CTCKKGFKGY NCQVNIDECA SNPCLNQGTC LDDVSGYTCH CMLPYTGKNC QTVLAPCSPN 840
  841 PCENAAVCKE APNFESFTCL CAPGWQGQRC TVDVDECVSK PCMNNGICHN TQGSYMCECP 900
  901 PGFSGMDCEE DINDCLANPC QNGGSCVDKV NTFSCLCLPG FVGDKCQTDM NECLSEPCKN 960
  961 GGTCSDYVNS YTCTCPAGFH GVHCENNIDE CTESSCFNGG TCVDGINSFS CLCPVGFTGP1020
 1021 FCLHDINECS SNPCLNSGTC VDGLGTYRCT CPLGYTGKNC QTLVNLCSPS PCKNKGTCAQ1080
 1081 EKARPRCLCP PGWDGAYCDV LNVSCKAAAL QKGVPVEHLC QHSGICINAG NTHHCQCPLG1140
 1141 YTGSYCEEQL DECASNPCQH GATCSDFIGG YRCECVPGYQ GVNCEYEVDE CQNQPCQNGG1200
 1201 TCIDLVNHFK CSCPPGTRGL LCEENIDDCA GAPHCLNGGQ CVDRIGGYSC RCLPGFAGER1260
 1261 CEGDINECLS NPCSSEGSLD CIQLKNNYQC VCRSAFTGRH CETFLDVCPQ KPCLNGGTCA1320
 1321 VASNVPDGFI CRCPPGFSGA RCQSSCGQVK CRRGEQCVHT ASGPHCFCPN HKDCESGCAS1380
 1381 NPCQHGGTCY PQRQPPYYSC RCSPPFWGSH CESYTAPTST PPATCLSQYC ADKARDGICD1440
 1441 EACNSHACQW DGGDCSLTME DPWANCTSSL RCWEYINNQC DELCNTAECL FDNFECQRNS1500
 1501 KTCKYDKYCA DHFKDNHCDK GCNNEECGWD GLDCAADQPE NLAEGILVIV VLLPPEQLLQ1560
 1561 DSRSFLRALG TLLHTNLRIK QDSQGALMVY PYYGEKSAAM KKQKVARRSL PDEQEQEIIG1620
 1621 SKVFLEIDNR QCVQDSDQCF KNTDAAAALL ASHAIQGTLS YPLVSVVSES EDPRNTPLLY1680
 1681 LLAVAVVIIL FLILLGVIMA KRKRKHGFLW LPEGFTLRRD SSNHKRREPV GQDAVGLKNL1740
 1741 SVQVSEANLI GSTTSEHWGD DEGPQPKKAK AEDDEALLSE DDPVDRRPWT QQHLEAADIR1800
 1801 RTPSLALTPP QAEQEVDVLD VNVRGPDGCT PLMLASLRGG SSDLSDEDED AEDSSANIIT1860
 1861 DLVYQGASLQ AQTDRTGEMA LHLAARYSRA DAAKRLLDAG ADANAQDNMG RCPLHAAVAA1920
 1921 DAQGVFQILI RNRVTDLDAR MNDGTTPLIL AARLAVEGMV AELINCQADV NAVDDHGKSA1980
 1981 LHWAAAVNNV EATLLLLKNG ANRDMQDNKE ETPLFLAARE GSYEAAKILL DHFANRDITD2040
 2041 HMDRLPRDVA RDRMHHDIVR LLDEYNVTPS PPGTVLTSAL SPVLCGPNRS FLSLKHTPMG2100
 2101 KKARRPNTKS TMPTSLPNLA KEAKDVKGSR RKKCLNEKVQ LSESSVTLSP VDSLESPHTY2160
 2161 VSDATSSPMI TSPGILQASP TPLLAAAPAA PVHAQHALSF SNLHEMQPLR PGASTVLPSV2220
 2221 SQLLSHHHIV PPGSGSAGSL GRLHSVPVPS DWMNRVEMSE TQYSEMFGMV LAPAEGTHPG2280
 2281 MAAPQSRAPE GKPIPTQREP LPPIVTFQLI PKGSLAQAAG APQTQSGCPP AVAGPLPSMY2340
 2341 QIPEMARLPS VAFPPTMMPQ QEGQVAQTIV PTYHPFPASV GKYPTPPSQH SYASSNAAER2400
 2401 TPNHGGHLQG EHPYLTPSPE SPDQWSSSSP HSASDWSDVT TSPTPGGGGG GQRGPGTHMS2460
 2461 EPPHSNMQVY A

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: NOTC2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: