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Protein Overview: HPPD_RAT

General Information:
Name(s) found: HPPD_RAT [Swiss-Prot]
Description(s) found:
Found 21 descriptions.
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  • 4-hydroxyphenylpyruvate dioxygenase OS=Rattus norvegicus GN=Hpd PE=1 SV=3 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 393 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDA]
    cytoplasm [IEA]
    membrane [IEA]
    cytosol [UNKNOWN]
    Golgi membrane [IDA]
    endoplasmic reticulum [IDA]
    Golgi apparatus [IDA]
    Biological Process: L-phenylalanine catabolic process [IEA]
    aromatic amino acid family metabolic process [IEA]
    tyrosine catabolic process [IDA][TAS]
    oxidation reduction [IEA]
    Molecular Function: 4-hydroxyphenylpyruvate dioxygenase activity [UNKNOWN][IDA][TAS]
    oxidoreductase activity [IEA]
    metal ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTYSNKGPK PERGRFLHFH SVTFWVGNAK QAASFYCNKM GFEPLAYKGL ETGSREVVSH  60
   61 VIKQGKIVFV LCSALNPWNK EMGDHLVKHG DGVKDIAFEV EDCEHIVQKA RERGAKIVRE 120
  121 PWVEEDKFGK VKFAVLQTYG DTTHTLVEKI NYTGRFLPGF EAPTYKDTLL PKLPSCNLEI 180
  181 IDHIVGNQPD QEMESASEWY LKNLQFHRFW SVDDTQVHTE YSSLRSIVVA NYEESIKMPI 240
  241 NEPAPGRKKS QIQEYVDYNG GAGVQHIALR TEDIITTIRH LRERGMEFLA VPSSYYRLLR 300
  301 ENLKTSKIQV KENMDVLEEL KILVDYDEKG YLLQIFTKPM QDRPTLFLEV IQRHNHQGFG 360
  361 AGNFNSLFKA FEEEQALRGN LTDLETNGVR SGM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..393] PSI-BLAST 100.0 Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 4-hydroxyphenylpyruvate dioxygenase activity
    		•  5.55625076505342 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
    		•  2.26788314282577 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
    		•  2.21815619779247 bayes_pls_golite062009
  • catalytic activity
    		•  1.21778090213032 bayes_pls_golite062009
  • binding
    		•  1.0574905568754 bayes_pls_golite062009
  • dioxygenase activity
    		•  0.768140787640544 bayes_pls_golite062009
  • protein binding
    		•  0.18929451652439 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle