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View Structure Prediction Details

Protein: HPPD_RAT
Organism: Rattus norvegicus
Length: 393 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HPPD_RAT.

Description E-value Query
Range
Subject
Range
gi|109099057 - gi|109099057|ref|XP_001096175.1| PREDICTED: 4-hydroxyphenylpyruvate dioxygenase isoform 2 [Macaca mu...
364.0 [0..1] [393..1]
gi|114647465 - gi|114647465|ref|XP_528667.2| PREDICTED: 4-hydroxyphenylpyruvate dioxygenase isoform 3 [Pan troglody...
361.0 [0..1] [393..1]
gi|3860238 - gi|3860238|gb|AAC73008.1| 4-hydroxyphenylpyruvate-dioxygenase [Homo sapiens]
360.0 [0..1] [393..1]
gi|113197875, gi... - gi|118404104|ref|NP_001072376.1| 4-hydroxyphenylpyruvate dioxygenase [Xenopus (Silurana) tropicalis]...
358.0 [0..1] [391..1]
HPPD_MOUSE - 4-hydroxyphenylpyruvate dioxygenase OS=Mus musculus GN=Hpd PE=1 SV=3
358.0 [0..1] [393..1]
gi|73995174 - gi|73995174|ref|XP_853422.1| PREDICTED: similar to 4-hydroxyphenylpyruvate dioxygenase (4HPPD) (HPD)...
355.0 [0..1] [393..1]
gi|157105932, gi... - gi|157105932|ref|XP_001649088.1| 4-hydroxyphenylpyruvate dioxygenase [Aedes aegypti], gi|108868917|g...
355.0 [0..1] [381..1]

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Predicted Domain #1
Region A:
Residues: [1-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTYSNKGPK PERGRFLHFH SVTFWVGNAK QAASFYCNKM GFEPLAYKGL ETGSREVVSH  60
   61 VIKQGKIVFV LCSALNPWNK EMGDHLVKHG DGVKDIAFEV EDCEHIVQKA RERGAKIVRE 120
  121 PWVEEDKFGK VKFAVLQTYG DTTHTLVEKI NYTGRFLPGF EAPTYKDTLL PKLPSCNLEI 180
  181 IDHIVGNQPD QEMESASEWY LKNLQFHRFW SVDDTQVHTE YSSLRSIVVA NYEESIKMPI 240
  241 NEPAPGRKKS QIQEYVDYNG GAGVQHIALR TEDIITTIRH LRERGMEFLA VPSSYYRLLR 300
  301 ENLKTSKIQV KENMDVLEEL KILVDYDEKG YLLQIFTKPM QDRPTLFLEV IQRHNHQGFG 360
  361 AGNFNSLFKA FEEEQALRGN LTDLETNGVR SGM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 100.0
Match: 1sqiA
Description: Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4-hydroxyphenylpyruvate dioxygenase activity 5.55625076505342 bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2.26788314282577 bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2.21815619779247 bayes_pls_golite062009
catalytic activity 1.21778090213032 bayes_pls_golite062009
binding 1.0574905568754 bayes_pls_golite062009
dioxygenase activity 0.768140787640544 bayes_pls_golite062009
protein binding 0.18929451652439 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle