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Protein Overview: MGMT_RAT

General Information:
Name(s) found: MGMT_RAT [Swiss-Prot]
Description(s) found:
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  • gi|6981202|ref|NP_036993.1| O-6-methylguanine-DNA methyltransferase [Rattus norvegicus] [NCBI NR]
  • gi|311909|emb|CAA38648.1| O(6)-alkylguanine-DNA-alkyltransferase [Rattus norvegicus] [NCBI NR]
  • pir||XURTMC methylated-DNA-protein-cysteine S-methyltransferase (EC 2.1.1.63) [similarity] - rat [NCBI NR]
  • gi|206685|gb|AAA42052.1| O-6-methylguanine-DNA methyltransferase [NCBI NR]
  • gi|149061382|gb|EDM11805.1| O-6-methylguanine-DNA methyltransferase, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|127071|sp|P24528.3|MGMT_RAT RecName: Full=Methylated-DNA--protein-cysteine methyltransferase; AltName: Full=6-O-methylguanine-DNA methyltransferase; Short=MGMT; AltName: Full=O-6-methylguanine-DNA-alkyltransferase [NCBI NR]
  • Methylated-DNA--protein-cysteine methyltransferase OS=Rattus norvegicus GN=Mgmt PE=1 SV=3 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):1-196357999 o6-methylguanine-DNA methyltranferase [hmr_yeast5_DM3-1_pombe.fasta]
  • 0-6-methylguanine-DNA methyltransferase; O6-methylguanine-DNA methyltranferase [HMR_022704-rand.fasta]
  • O-6-methylguanine-DNA methyltransferase [Rattus norvegicus]gi|311909|emb|CAA38648.1| O(6)-alkylguanine-DNA-alkyltransferase [Rattus norvegicus]gi|127071|sp|P24528|MGMT_RAT Methylated-DNA--protein-cysteine methyltransferase (6-O-methylguanine-DNA methylt [nrdb_11152004_Chlamydomonas]
  • (NM_012861) o6-methylguanine-DNA methyltranferase [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Methylated-DNA--protein-cysteine methyltransferase (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • O-6-methylguanine-DNA methyltransferase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • O-6-methylguanine-DNA methyltransferase, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • O(6)-alkylguanine-DNA-alkyltransferase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • O-6-methylguanine-DNA methyltransferase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 O-6-METHYLGUANINE-DNA METHYLTRANSFERASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Mgmt Methylated-DNA--protein-cysteine methyltransferase [rat-ipi-250309-contam.fasta]
  • methylated-DNA--protein-cysteine methyltransferase [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Methylated-DNA--protein-cysteine methyltransferase OS=Rattus norvegicus GN=Mgmt [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 209 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    nucleoplasm [UNKNOWN]
    Biological Process: positive regulation of DNA repair [IDA]
    DNA repair [UNKNOWN][IEA]
    negative regulation of cell death [IDA]
    response to organic cyclic substance [IEP]
    response to DNA damage stimulus [UNKNOWN][IEP]
    response to toxin [IEP]
    mammary gland epithelial cell differentiation [IEP]
    DNA dealkylation involved in DNA repair [UNKNOWN][IDA]
    response to ethanol [IEP]
    regulation of caspase activity [UNKNOWN][IEA]
    response to drug [IEP]
    response to folic acid [IEP]
    cellular response to ionizing radiation [IEP]
    cellular response to oxidative stress [IEP]
    cellular response to organic cyclic substance [IEP]
    Molecular Function: DNA binding [IEA]
    catalytic activity [IEA]
    calcium ion binding [IDA]
    methyltransferase activity [UNKNOWN][IEA]
    methylated-DNA-[protein]-cysteine S-methyltransferase activity [UNKNOWN][IDA][IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEICKMKYT VLDSPLGKIE LSGCERGLHG IRFLSGKTPN TDPTEAPACP EVLGGPEGVP  60
   61 EPLVQCTAWL EAYFHEPAAT EGLPLPALHH PVFQQDSFTR QVLWKLLKVV KFGEMVSYQQ 120
  121 LAALAGNPKA ARAVGGAMRS NPVPILIPCH RVIRSDGAIG NYSGGGQTVK EWLLAHEGIP 180
  181 TGQPASKGLG LIGSWLKPSF ESSSPKPSG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle