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Protein Overview: GSH1_RAT

General Information:
Name(s) found: GSH1_RAT [Swiss-Prot]
Description(s) found:
Found 19 descriptions.
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  • Glutamate--cysteine ligase catalytic subunit OS=Rattus norvegicus GN=Gclc PE=1 SV=2 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 637 amino acids

    Gene Ontology:
    Cellular Component: glutamate-cysteine ligase complex [UNKNOWN][IDA]
    cytosol [UNKNOWN][IEA]
    Biological Process: glutathione biosynthetic process [UNKNOWN][IMP][ISS]
    cell redox homeostasis [UNKNOWN][ISS]
    response to xenobiotic stimulus [UNKNOWN][IEA]
    cysteine metabolic process [UNKNOWN][ISS]
    response to hormone stimulus [UNKNOWN][ISS]
    negative regulation of neuron apoptosis [IMP]
    response to oxidative stress [UNKNOWN][IMP][ISS]
    glutamate metabolic process [UNKNOWN][ISS]
    response to heat [UNKNOWN][ISS]
    anti-apoptosis [UNKNOWN][ISS]
    response to arsenic [UNKNOWN][IEA]
    regulation of blood vessel size [UNKNOWN][ISS]
    glutathione metabolic process [UNKNOWN]
    negative regulation of transcription [UNKNOWN][ISS]
    negative regulation of apoptosis [UNKNOWN]
    response to nitrosative stress [IMP]
    L-ascorbic acid metabolic process [UNKNOWN][IEA]
    negative regulation of protein ubiquitination [UNKNOWN][IEA]
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process [UNKNOWN][IEA]
    regulation of mitochondrial depolarization [UNKNOWN][IEA]
    Molecular Function: nucleotide binding [IEA]
    magnesium ion binding [UNKNOWN][ISS]
    ATP binding [IEA]
    coenzyme binding [UNKNOWN][ISS]
    protein heterodimerization activity [UNKNOWN][IDA]
    glutamate binding [UNKNOWN][ISS]
    ADP binding [UNKNOWN][ISS]
    glutamate-cysteine ligase activity [UNKNOWN][IMP][ISS]
    ligase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLSQGSPL SWEETQRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH  60
   61 ENRKVQLLLN GGDVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 120
  121 EDNMRKRRKE ATSVLGEHQA LCTITSFPRL GCPGFTLPEH RPNPEEGGAS KSLFFPDEAI 180
  181 NKHPRFGTLT RNIRHRRGEK VVINVPIFKD KNTPSPFVET FPEDEEASKA SKPDHIYMDA 240
  241 MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 300
  301 SASVDDRTRE ERGLEPLKNN RFKISKSRYD SIDSYLSKCG EKYNDIDLTI DTEIYEQLLE 360
  361 EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 420
  421 GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IPLSKVDENM KVAQERDAVL 480
  481 QGMFYFRKDI CKGGNAVVDG CSKAQTSSEP SAEEYTLMSI DTIINGKEGV FPGLIPILNS 540
  541 YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEINYS 600
  601 LILKCNQIAN ELCECPELLG SGFRKAKYSG GKSDPSD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle