General Information: |
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Name(s) found: |
GSH1_RAT
[Swiss-Prot]
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Description(s) found:
SHOW ONLY BEST |
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Organism: | Rattus norvegicus |
Length: | 637 amino acids |
Gene Ontology: |
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Cellular Component: |
glutamate-cysteine ligase complex
[UNKNOWN][IDA]
cytosol [UNKNOWN][IEA] |
Biological Process: |
glutathione biosynthetic process
[UNKNOWN][IMP][ISS]
cell redox homeostasis [UNKNOWN][ISS] response to xenobiotic stimulus [UNKNOWN][IEA] cysteine metabolic process [UNKNOWN][ISS] response to hormone stimulus [UNKNOWN][ISS] negative regulation of neuron apoptosis [IMP] response to oxidative stress [UNKNOWN][IMP][ISS] glutamate metabolic process [UNKNOWN][ISS] response to heat [UNKNOWN][ISS] anti-apoptosis [UNKNOWN][ISS] response to arsenic [UNKNOWN][IEA] regulation of blood vessel size [UNKNOWN][ISS] glutathione metabolic process [UNKNOWN] negative regulation of transcription [UNKNOWN][ISS] negative regulation of apoptosis [UNKNOWN] response to nitrosative stress [IMP] L-ascorbic acid metabolic process [UNKNOWN][IEA] negative regulation of protein ubiquitination [UNKNOWN][IEA] positive regulation of proteasomal ubiquitin-dependent protein catabolic process [UNKNOWN][IEA] regulation of mitochondrial depolarization [UNKNOWN][IEA] |
Molecular Function: |
nucleotide binding
[IEA]
magnesium ion binding [UNKNOWN][ISS] ATP binding [IEA] coenzyme binding [UNKNOWN][ISS] protein heterodimerization activity [UNKNOWN][IDA] glutamate binding [UNKNOWN][ISS] ADP binding [UNKNOWN][ISS] glutamate-cysteine ligase activity [UNKNOWN][IMP][ISS] ligase activity [IEA] |
Sequence: |
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Sequence: [PDR BLAST] [ProtParam] |
1 11 21 31 41 51 | | | | | | 1 MGLLSQGSPL SWEETQRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH 60 61 ENRKVQLLLN GGDVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 120 121 EDNMRKRRKE ATSVLGEHQA LCTITSFPRL GCPGFTLPEH RPNPEEGGAS KSLFFPDEAI 180 181 NKHPRFGTLT RNIRHRRGEK VVINVPIFKD KNTPSPFVET FPEDEEASKA SKPDHIYMDA 240 241 MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 300 301 SASVDDRTRE ERGLEPLKNN RFKISKSRYD SIDSYLSKCG EKYNDIDLTI DTEIYEQLLE 360 361 EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 420 421 GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IPLSKVDENM KVAQERDAVL 480 481 QGMFYFRKDI CKGGNAVVDG CSKAQTSSEP SAEEYTLMSI DTIINGKEGV FPGLIPILNS 540 541 YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEINYS 600 601 LILKCNQIAN ELCECPELLG SGFRKAKYSG GKSDPSD |
NOT SHOWING SINGLE HITS. [ Show Single Hits ]
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Protein predicted to be: | GLOBULAR (No transmembrane regions or signal peptide) |
Confidence of classification: | 0.95 |
Source: Reynolds et al. (2008)