Protein Overview: ROCK1_RAT

General Information:
Name(s) found:	ROCK1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|47605939\|sp\|Q63644.1\|ROCK1_RAT RecName: Full=Rho-associated protein kinase 1; AltName: Full=Rho-associated, coiled-coil-containing protein kinase 1; AltName: Full=p160 ROCK-1; Short=p160ROCK; AltName: Full=p150 RhoA-binding kinase ROK beta; AltName: Fu [NCBI NR] gi\|1438567\|gb\|AAB37571.1\| Rho-associated kinase beta [NCBI NR] gi\|13592049\|ref\|NP_112360.1\| Rho-associated, coiled-coil containing protein kinase 1 [Rattus norvegicus] [NCBI NR] Rho-associated protein kinase 1 OS=Rattus norvegicus GN=Rock1 PE=1 SV=1 [Swiss-Prot] (Q63644) Rho-associated protein kinase 1 (EC 2.7.1.37) (Rho-associated, coiled-coil containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (p150 RhoA-binding kinase ROK beta) [Swiss-Prot] Ensembl_locations(Chr-bp):18-87968254 Rho-associated kinase beta [hmr_yeast5_DM3-1_pombe.fasta] Rho-associated kinase beta [HMR_022704-rand.fasta] Rho-associated kinase beta [Rattus norvegicus]gi\|1438567\|gb\|AAB37571.1\| Rho-associated kinase betagi\|47605939\|sp\|Q63644\|ROC1_RAT Rho-associated protein kinase 1 (Rho-associated, coiled-coil containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (p150 Rho [nrdb_11152004_Chlamydomonas] (NM_031098) Rho-associated kinase beta [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Tax_Id=10116 Splice Isoform 1 of Rho-associated protein kinase 1 [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta] Rho-associated coiled-coil containing protein kinase 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Rho-associated protein kinase 1 (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (p150 RhoA-binding kinase ROK beta) (Liver regeneration-related protein LRRG199) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF RHO-ASSOCIATED PROTEIN KINASE 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Rho-associated coiled-coil forming kinase 1 [Rattus norvegicus] [nr-271106-contam.fasta] Isoform 1 of Rho-associated protein kinase 1 OS=Rattus norvegicus GN=Rock1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1369 amino acids
Gene Ontology:
Cellular Component:	cytoskeleton [IEA] cytoplasm [IEA] centriole [IEA] membrane [IEA] cytosol [UNKNOWN] Golgi membrane [IEA] Golgi apparatus [IEA] intracellular [IEA]
Biological Process:	bleb assembly [UNKNOWN][IEA] cytoskeleton organization [IMP] signal transduction [IEA] cytokinesis [IEA] Rho protein signal transduction [IMP] membrane to membrane docking [UNKNOWN][IEA] protein amino acid phosphorylation [IEA] leukocyte cell-cell adhesion [UNKNOWN] negative regulation of neuron apoptosis [UNKNOWN][IEA] apoptosis [IEA] leukocyte migration [UNKNOWN][IEA] leukocyte tethering or rolling [UNKNOWN][IEA] actin cytoskeleton organization [UNKNOWN][IEA]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] identical protein binding [UNKNOWN][IEA] protein binding [IEA] metal ion binding [IEA] protein serine/threonine kinase activity [IEA][NAS] transferase activity [IEA] GTP-Rho binding [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTGDSFETR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK NIDNFLSRYK  60
   61 DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF 120
  121 FWEERDIMAF ANSPWVVQLF YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA 180
  181 EVVLALDAIH SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY 240
  241 ISPEVLKSQG GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP 300
  301 DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD TVAPVVPDLS 360
  361 SDIDTSNFDD LEEDKGDEET FPIPKAFVGN QLPFVGFTYY SNRRYLPSAN PSENRSSSNV 420
  421 DKNVQESLQK TIYKLEEQLH NEMQLKDEME QKCRTSNIKL DKIMKELDEE GNQRRNLESA 480
  481 VSQIEKEKML LQHRINEYQR KVEQENEKRR NVENEVSTLK DQLEDLRKAS QSSQLANEKL 540
  541 TQLQKQLEEA NDLLRTESDT AVRLRKSHTE MSKSVSQLES LNRELQERNR MLENSKSQAD 600
  601 KDYYQLQAVL EAERRDRGHD SEMIGDLQAR ITSLQEEVKH LKHNLERVEG ERKEAQDMLN 660
  661 HSEKEKNNLE IDLNYKLKSI QQRLEQEVNE HKVTKARLTD KHQSIEEAKS VAMCEMEKKL 720
  721 KEEREAREKA ENRVVETEKQ CSMLDVDLKQ SQQKLEHLTE NKERLEDAVK SLTLQLEQES 780
  781 NKRILLQSEL KTQAFEADNL KGLEKQMKQE INTLLEAKRL LEFELAQLTK QYRGNEGQMR 840
  841 ELQDQLEAEQ YFSTLYKTQV KELKEEIEEK NRENLRKIQE LQSEKETLST QLDLAETKAE 900
  901 SEQLARGILE EQYFELTQES KKAASRNRQE ITDKDHTVSR LEEANNALTK DIELLRKENE 960
  961 ELNERMRTAE EEYKLKKEEE ISNLKAAFEK NISTERTLKT QAVNKLAEIM NRKDFKIDRK1020
 1021 KANTQDLRKK EKENRKLQLE LNQEREKFNQ MVVKHQKELN DMQAQLVEEC THRNELQMQL1080
 1081 ASKESDIEQL RAKLLDLSDS TSVASFPSAD ETDGNLPVGS ACIPYLFIFY SSSSRIEGWL1140
 1141 SVPNRGNIKR YGWKKQYVVV SSKKMLFYND EQDKEQSSPS MVLDIDKLFH VRPVTQGDVY1200
 1201 RAETEEIPKI FQILYANEGE CRKDIEVEPV QQGEKTNFQN HKGHEFIPTL YHFPANCEAC1260
 1261 AKPLWHVFKP PPALECRRCH VKSHRDHLDK KEDLIPPCKV SYDVTSARDM LLLACPQDEQ1320
 1321 KKWVTHLVKK IPKKAPSGFV RASPRTLSTR STANQSFRKV VKNTSGKTS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: ROCK1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: