Protein Overview: VHL_RAT

General Information:
Name(s) found:	VHL_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|882108\|gb\|AAA86874.1\| VHL protein [NCBI NR] pir\|\|T10752 VHL protein - rat [NCBI NR] gi\|32469798\|sp\|Q64259.1\|VHL_RAT RecName: Full=Von Hippel-Lindau disease tumor suppressor; AltName: Full=pVHL [NCBI NR] gi\|16258813\|ref\|NP_434688.1\| von Hippel-Lindau tumor suppressor [Rattus norvegicus] [NCBI NR] gi\|149036933\|gb\|EDL91551.1\| von Hippel-Lindau syndrome homolog, isoform CRA_a [Rattus norvegicus] [NCBI NR] Von Hippel-Lindau disease tumor suppressor OS=Rattus norvegicus GN=Vhl PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):4-154820474 VHL protein [hmr_yeast5_DM3-1_pombe.fasta] von Hippel-Lindau syndrome homolog [HMR_022704-rand.fasta] von Hippel-Lindau syndrome homolog [Rattus norvegicus]gi\|32469798\|sp\|Q64259\|VHL_RAT Von Hippel-Lindau disease tumor suppressor (pVHL)gi\|7514117\|pir\|\|T10752 VHL protein - ratgi\|1245912\|gb\|AAB35675.1\| von Hippel-Lindau tumor suppressor gene homolog [Ratt [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Von Hippel-Lindau disease tumor suppressor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_052801) von Hippel-Lindau syndrome [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] von Hippel-Lindau syndrome homolog [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Von Hippel-Lindau disease tumor suppressor (pVHL) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] von Hippel-Lindau syndrome homolog, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] VHL protein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] von Hippel-Lindau tumor suppressor [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Vhl Von Hippel-Lindau disease tumor suppressor [rat-ipi-250309-contam.fasta] Von Hippel-Lindau disease tumor suppressor OS=Rattus norvegicus GN=Vhl [011711_HMR.fasta] Von Hippel-Lindau disease tumor suppressor OS=Rattus norvegicus GN=Vhl PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	185 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] transcription factor complex [TAS] cytoplasm [IEA] membrane [IEA] VCB complex [IDA] cytosol [IDA]
Biological Process:	negative regulation of transcription from RNA polymerase II promoter [IMP] response to hypoxia [IMP] angiogenesis [UNKNOWN][IEA] protein catabolic process [UNKNOWN][IEA] extracellular matrix organization [UNKNOWN][IEA] regulation of transcription, DNA-dependent [IDA] positive regulation of transcription [UNKNOWN][IEA] protein heterooligomerization [IPI] regulation of catecholamine metabolic process [IMP] blood vessel endothelial cell migration [UNKNOWN][IEA] regulation of transcription [UNKNOWN] protein ubiquitination [UNKNOWN][IEA]
Molecular Function:	ubiquitin-protein ligase activity [IC] protein binding [UNKNOWN][IC] transcription factor binding [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRKAASPEE AERMPGSEEI EAGRPRPVLR SVNSREPSQV IFCNRSPRVV LPLWLNFDGE  60
   61 PQPYPTLPPG TGRRIHSYRG HLWLFRDAGT HDGLLVNQTE LFVPSLNVDG QPIFANITLP 120
  121 VYTLKERCLQ VVRSLVKPEN YRRLDIVRSL YEDLEDHPNV RKDIQRLTQE HLENQALGEE 180
  181 PEGVH

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: VHL_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: