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Protein Overview: VHL_RAT

General Information:
Name(s) found: VHL_RAT [Swiss-Prot]
Description(s) found:
Found 20 descriptions.
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  • Von Hippel-Lindau disease tumor suppressor OS=Rattus norvegicus GN=Vhl PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 185 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    transcription factor complex [TAS]
    cytoplasm [IEA]
    membrane [IEA]
    VCB complex [IDA]
    cytosol [IDA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMP]
    response to hypoxia [IMP]
    angiogenesis [UNKNOWN][IEA]
    protein catabolic process [UNKNOWN][IEA]
    extracellular matrix organization [UNKNOWN][IEA]
    regulation of transcription, DNA-dependent [IDA]
    positive regulation of transcription [UNKNOWN][IEA]
    protein heterooligomerization [IPI]
    regulation of catecholamine metabolic process [IMP]
    blood vessel endothelial cell migration [UNKNOWN][IEA]
    regulation of transcription [UNKNOWN]
    protein ubiquitination [UNKNOWN][IEA]
    Molecular Function: ubiquitin-protein ligase activity [IC]
    protein binding [UNKNOWN][IC]
    transcription factor binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRKAASPEE AERMPGSEEI EAGRPRPVLR SVNSREPSQV IFCNRSPRVV LPLWLNFDGE  60
   61 PQPYPTLPPG TGRRIHSYRG HLWLFRDAGT HDGLLVNQTE LFVPSLNVDG QPIFANITLP 120
  121 VYTLKERCLQ VVRSLVKPEN YRRLDIVRSL YEDLEDHPNV RKDIQRLTQE HLENQALGEE 180
  181 PEGVH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle