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Protein Overview: DPOLA_RAT

General Information:
Name(s) found: DPOLA_RAT [Swiss-Prot]
Description(s) found:
Found 12 descriptions.
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  • DNA polymerase alpha catalytic subunit (Fragment) OS=Rattus norvegicus GN=Pola1 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1451 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [ISS]
    nucleus [IEA][IMP][ISS]
    alpha DNA polymerase:primase complex [IC][IDA][ISS]
    nuclear matrix [ISS]
    nucleolus [ISS]
    chromatin [ISS]
    nucleoplasm [ISS]
    Biological Process: cell proliferation [ISS]
    DNA replication initiation [ISS]
    DNA repair [ISS]
    lagging strand elongation [ISS]
    S phase of mitotic cell cycle [ISS]
    DNA replication [IEA][IMP][ISS]
    DNA strand elongation involved in DNA replication [ISS]
    leading strand elongation [ISS]
    DNA synthesis involved in DNA repair [ISS]
    double-strand break repair via nonhomologous end joining [ISS]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    Molecular Function: nucleotidyltransferase activity [IEA]
    double-stranded DNA binding [IDA]
    chromatin binding [ISS]
    nucleoside binding [IEA]
    nucleotide binding [IEA][ISS]
    DNA primase activity [ISS]
    DNA binding [IEA][ISS]
    DNA-directed DNA polymerase activity [IDA][IEA][IMP][ISS]
    protein binding [IEA]
    metal ion binding [IEA]
    protein heterodimerization activity [IEA]
    purine nucleotide binding [IMP]
    pyrimidine nucleotide binding [IMP]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPVHGDDCK LETSAVSDSG SFVASRARRE KKSKKGRQEA LERLKKAKAG EKYKYEVEDL  60
   61 TSVYEEVDEE QYSKLVQARQ DDDWIVDDDG IGYVEDGREI FDDDLEDDAL DTCGEGSDGK 120
  121 AHRKDRKDVK KPSVTKPNNI KAMFIASAGK KTTDKTVDLS KDDLLGDILQ DLNTETPQIA 180
  181 PPPVLIPKKK RSTGASPNPF SVHTATAVPS GKIASPVSRK EPPLTPVPLK RAEFAGDLAQ 240
  241 PECPEDEQES GVIEFEDGDF DEPMDTEEVD EEEPVTAKIW DQESEPVEGV KHEADPETGT 300
  301 TSFLDSFLPD VSCWDIDQKD ENSFLLQEVQ VDSNHLPLVK GADDEQVFQF YWLDAYEDPY 360
  361 NQPGVVFLFG KVWVESAKTH VSCCVMVKNI ERTLYFLPRE MKIDLNTGKE TATPITMKDV 420
  421 YEEFDSKISA KYKIMKFKSK IVEKNYAFEI PDVPEKSEYL EVRYSAEVPQ LPQNLKGETF 480
  481 SHVFGTNTSS LELFLMNRKI KGPCWLEVKN PQLLNQPISW CKFEAMALKP DLVNVIKDVS 540
  541 PPPLVVMSFS MKTMQNVQNH QHEIIAMAAL VHHNFPLDKA PPKPPFQTHF CVVSKPKDCI 600
  601 FPCAFKEVIK KKNMEVEVAA TERTLLGFFL AKVHKLDPDI LVGHNICGFE LEVLLQRINE 660
  661 CKVPFWSKIG RLRRSNMPKL GSRSGFGERN ATCGRMICDV EISVKELIHC KSYHLSELVQ 720
  721 QILKTERIVI PTENIRNMYS EPSHLLYLLE HIWKDARFIL QIMCELNVLP LALQITNIAG 780
  781 NIMSRTLMGG RSERNEFLLL HAFYENNYIV PDKQIFRKPQ QKPGDEDEEI DGDTNKYKKG 840
  841 RKKAAYAGGL VLDPKVGFYD KFILLLDFNS LYPSIIQEFN ICFTTVQRVA SETLKATEDE 900
  901 EQEQIPELPD PNLDMGILPR EIRKLVERRK QVKQLMKQQD LNPDLVLQYD IRQKALKLTA 960
  961 NSMYGCLGFS YSRFYAKPLA ALVTYKGREI LMHTKEMVQK MNLEVIYGDT DSIMINTNST1020
 1021 NLEEVFKLGN KVKNEVNKLY KLLEIDIDGV FKSLLLLKKK KYAALVVEPT SDGNYITKQE1080
 1081 LKGLDIVRRD WCDLAKDTGN FVIGQILSDQ SRDTIVENIQ KRLIEIGENV LNGSVPVSQF1140
 1141 EINKALTKDP QDYPDKKSLP HVHVALWINS QGGRKVKAGD TVSYVICQDG SNLPATQRAY1200
 1201 APEQLQKQDN LAIDTQYYLA QQIHPVVARI CEPIDGIDAV LIALWLGLDS TQFRVHQYHK1260
 1261 DEENDALLGG PAQLTDEEKY KDCEKFKCLC PSCGTENIYD NVFEGSGMDM EPSLNRCSNI1320
 1321 DCKASPATFM VQLSNKLIMD IRRCIKKYYD GWLICEEPTC RNRIRRLPLH FSRNGPLCPA1380
 1381 CMKAVLRPEY SDKSLYTQLC FYRYIFDADC ALEKLPEHEK DKLKKQFFTP RVLQDYRKVK1440
 1441 NIAEHFLSWS G

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle