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Protein Overview: NOGG_RAT

General Information:
Name(s) found: NOGG_RAT [Swiss-Prot]
Description(s) found:
Found 9 descriptions.
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  • Noggin (Fragment) OS=Rattus norvegicus GN=Nog PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 144 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][IEA]
    extracellular region [UNKNOWN][IEA]
    cellular_component [ND]
    Biological Process: negative regulation of cardiac muscle cell proliferation [ISS]
    negative regulation of cartilage development [UNKNOWN]
    middle ear morphogenesis [UNKNOWN][IEA]
    negative regulation of astrocyte differentiation [IMP][ISS]
    regulation of neuron differentiation [IMP]
    positive regulation of glomerulus development [ISS]
    negative regulation of cytokine activity [UNKNOWN][IEA]
    dorsal/ventral pattern formation [UNKNOWN][IEA]
    embryonic digit morphogenesis [UNKNOWN][IEA]
    wound healing [ISS]
    skeletal system development [UNKNOWN]
    forebrain development [IEP]
    in utero embryonic development [UNKNOWN][IEA]
    negative regulation of cell differentiation [IEA]
    BMP signaling pathway [UNKNOWN]
    mesenchymal cell differentiation [UNKNOWN][IEA]
    osteoblast differentiation [ISS]
    somatic stem cell maintenance [UNKNOWN][IEA]
    positive regulation of epithelial cell proliferation [UNKNOWN][IEA]
    limb development [UNKNOWN][IEA]
    embryonic skeletal joint morphogenesis [UNKNOWN][IEA]
    pattern specification process [UNKNOWN][IEA]
    anatomical structure formation involved in morphogenesis [UNKNOWN][IEA]
    brain development [UNKNOWN]
    embryonic skeletal system development [UNKNOWN][IEA]
    pituitary gland development [UNKNOWN][IEA]
    prostatic bud formation [UNKNOWN][IEA]
    negative regulation of BMP signaling pathway [UNKNOWN][ISS]
    positive regulation of branching involved in ureteric bud morphogenesis [ISS]
    urogenital system development [UNKNOWN][IEA]
    central nervous system development [UNKNOWN]
    notochord morphogenesis [UNKNOWN][IEA]
    ureteric bud development [UNKNOWN][IEA]
    epithelial to mesenchymal transition [ISS]
    regulation of BMP signaling pathway [UNKNOWN]
    cartilage development [IEA]
    Molecular Function: protein binding [UNKNOWN][IDA]
    protein homodimerization activity [UNKNOWN][IEA]
    cytokine binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGGGPAGGA EDLAELDQLL RQRPSGAMPS EIKGLEFSEG LAQGKKQRLS KKLRRKLQMW  60
   61 LWSQTFCPVL YAWNDLGSRF WARYVKVGSC FSKRSCSVPE GMVCKPSKSV HLTVLRWRCQ 120
  121 RRGGQRCGWI PIQYPIISEC KCSC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] PSI-BLAST 67.0 Noggin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • receptor serine/threonine kinase binding
    		•  4.8369569327215 bayes_pls_golite062009
  • growth factor activity
    		•  4.74498867224238 bayes_pls_golite062009
  • receptor binding
    		•  4.70889547404918 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  4.69128752159226 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  4.69128752159226 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 1 binding
    		•  3.6158922900246 bayes_pls_golite062009
  • cytokine activity
    		•  3.61376517935324 bayes_pls_golite062009
  • protein binding
    		•  3.16282476674164 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  3.06631842262117 bayes_pls_golite062009
  • cell surface binding
    		•  2.9725198156666 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 2 binding
    		•  2.88765567751765 bayes_pls_golite062009
  • vascular endothelial growth factor receptor binding
    		•  2.76400237542695 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.49731836866959 bayes_pls_golite062009
  • growth factor binding
    		•  2.41942870726502 bayes_pls_golite062009
  • binding
    		•  2.37954321554411 bayes_pls_golite062009
  • heparin binding
    		•  2.11784489374422 bayes_pls_golite062009
  • platelet-derived growth factor binding
    		•  2.01091405432331 bayes_pls_golite062009
  • hormone activity
    		•  1.83166472515554 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  1.78479767888975 bayes_pls_golite062009
  • collagen binding
    		•  1.64555624988816 bayes_pls_golite062009
  • glial cell line-derived neurotrophic factor receptor binding
    		•  1.5411449057785 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.44846386076063 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.16191864095271 bayes_pls_golite062009
  • protein homodimerization activity
    		•  1.13743310822539 bayes_pls_golite062009
  • identical protein binding
    		•  1.0030262164995 bayes_pls_golite062009
  • morphogen activity
    		•  0.91146826241391 bayes_pls_golite062009
  • pattern binding
    		•  0.90497366619649 bayes_pls_golite062009
  • neurotrophin receptor binding
    		•  0.81172494974121 bayes_pls_golite062009
  • vascular endothelial growth factor receptor 3 binding
    		•  0.583797120004309 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.408562885230686 bayes_pls_golite062009
  • signal transducer activity
    		•  0.102347067903142 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.102347067903142 bayes_pls_golite062009
  • fibronectin binding
    		•  0.0979012997097199 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.0235054088545197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle