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View Structure Prediction Details

Protein: NOGG_RAT
Organism: Rattus norvegicus
Length: 144 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOGG_RAT.

Description E-value Query
Range
Subject
Range
gi|60810121 - gi|60810121|gb|AAX36116.1| noggin [synthetic construct]
253.0 [0..11] [144..99]
gi|114669450 - gi|114669450|ref|XP_523802.2| PREDICTED: noggin [Pan troglodytes]
253.0 [0..11] [144..99]
NOGG_MOUSE - Noggin OS=Mus musculus GN=Nog PE=2 SV=1
gi|34873295, gi|... - ref|XP_343955.1| similar to noggin [Rattus norvegicus], gi|158187531|ref|NP_037122.1| noggin [Rattu...
253.0 [0..11] [144..99]
gi|109114412 - gi|109114412|ref|XP_001104355.1| PREDICTED: noggin [Macaca mulatta]
NOG - noggin
253.0 [0..11] [144..99]
gi|109491640 - gi|109491640|ref|XP_001081231.1| PREDICTED: similar to Noggin precursor [Rattus norvegicus]
249.0 [0..11] [144..343]
gi|76642650 - gi|76642650|ref|XP_582573.2| PREDICTED: similar to Noggin precursor [Bos taurus]
248.0 [0..11] [144..328]
gi|21105761 - gi|21105761|gb|AAM34779.1|AF510666_1 noggin [Equus caballus]
241.0 [0..11] [139..99]

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Predicted Domain #1
Region A:
Residues: [1-144]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGGGPAGGA EDLAELDQLL RQRPSGAMPS EIKGLEFSEG LAQGKKQRLS KKLRRKLQMW  60
   61 LWSQTFCPVL YAWNDLGSRF WARYVKVGSC FSKRSCSVPE GMVCKPSKSV HLTVLRWRCQ 120
  121 RRGGQRCGWI PIQYPIISEC KCSC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.0
Match: 1m4uA
Description: Noggin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor serine/threonine kinase binding 4.8369569327215 bayes_pls_golite062009
growth factor activity 4.74498867224238 bayes_pls_golite062009
receptor binding 4.70889547404918 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 4.69128752159226 bayes_pls_golite062009
transforming growth factor beta receptor binding 4.69128752159226 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 3.6158922900246 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
protein binding 3.16282476674164 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 3.06631842262117 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 2.88765567751765 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 2.76400237542695 bayes_pls_golite062009
glycosaminoglycan binding 2.49731836866959 bayes_pls_golite062009
growth factor binding 2.41942870726502 bayes_pls_golite062009
binding 2.37954321554411 bayes_pls_golite062009
heparin binding 2.11784489374422 bayes_pls_golite062009
platelet-derived growth factor binding 2.01091405432331 bayes_pls_golite062009
hormone activity 1.83166472515554 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.78479767888975 bayes_pls_golite062009
collagen binding 1.64555624988816 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 1.5411449057785 bayes_pls_golite062009
protein dimerization activity 1.44846386076063 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
protein homodimerization activity 1.13743310822539 bayes_pls_golite062009
identical protein binding 1.0030262164995 bayes_pls_golite062009
morphogen activity 0.91146826241391 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.583797120004309 bayes_pls_golite062009
protein heterodimerization activity 0.408562885230686 bayes_pls_golite062009
signal transducer activity 0.102347067903142 bayes_pls_golite062009
molecular transducer activity 0.102347067903142 bayes_pls_golite062009
fibronectin binding 0.0979012997097199 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle