Protein Overview: SMO_RAT

General Information:
Name(s) found:	SMO_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6981564\|ref\|NP_036939.1\| smoothened homolog [Rattus norvegicus] [NCBI NR] gi\|6226144\|sp\|P97698.1\|SMO_RAT RecName: Full=Smoothened homolog; Short=SMO; Flags: Precursor [NCBI NR] gi\|1813878\|gb\|AAB41789.1\| smoothened [Rattus norvegicus] [NCBI NR] Smoothened homolog OS=Rattus norvegicus GN=Smo PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):4-60887541 Smoothened homolog precursor [hmr_yeast5_DM3-1_pombe.fasta] smoothened homolog; Smoothened [HMR_022704-rand.fasta] smoothened homolog [Rattus norvegicus]gi\|6226144\|sp\|P97698\|SMO_RAT Smoothened homolog precursor (SMO)gi\|1813878\|gb\|AAB41789.1\| smoothened [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Smoothened homolog precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_012807) smoothened [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Smoothened homolog precursor (SMO) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] smoothened homolog [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] smoothened [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SMOOTHENED HOMOLOG PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Smo Smoothened homolog [rat-ipi-250309-contam.fasta] smoothened homolog precursor [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Smoothened homolog OS=Rattus norvegicus GN=Smo [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	793 amino acids
Gene Ontology:
Cellular Component:	cilium [UNKNOWN][IEA] integral to membrane [IEA] neuronal cell body [IDA] plasma membrane [UNKNOWN]
Biological Process:	multicellular organism growth [UNKNOWN][IEA] smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation [UNKNOWN][IEA] epithelial-mesenchymal cell signaling [UNKNOWN] positive regulation of cell proliferation [UNKNOWN] response to wounding [IEP] central nervous system neuron differentiation [UNKNOWN][IEA] odontogenesis of dentine-containing tooth [UNKNOWN][IEA] vasculogenesis [UNKNOWN][IEA] smoothened signaling pathway involved in ventral spinal cord patterning [UNKNOWN][IEA] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA] cerebellar cortex morphogenesis [UNKNOWN][IEA] dorsal/ventral pattern formation [UNKNOWN] heart morphogenesis [UNKNOWN][IEA] negative regulation of DNA binding [UNKNOWN][IEA] facial nerve development [IEP] in utero embryonic development [UNKNOWN] osteoblast differentiation [UNKNOWN][IEA] cell fate specification [UNKNOWN][IEA] positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN] positive regulation of epithelial cell proliferation [UNKNOWN] negative regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN] dorsal/ventral neural tube patterning [UNKNOWN][IEA] positive regulation of protein import into nucleus [UNKNOWN][IEA] G-protein coupled receptor protein signaling pathway [IEA] signal transduction [IEA] positive regulation of neuroblast proliferation [UNKNOWN][IEA] smoothened signaling pathway [UNKNOWN] pattern specification process [UNKNOWN][IEA] positive regulation of mesenchymal cell proliferation [UNKNOWN] cell development [UNKNOWN][IEA] developmental growth [UNKNOWN][IEA] determination of left/right symmetry [UNKNOWN][IEA] central nervous system development [UNKNOWN] neural crest cell migration [UNKNOWN][IEA] negative regulation of apoptosis [UNKNOWN][IEA] positive regulation of smoothened signaling pathway [UNKNOWN][IEA] regulation of gene expression [UNKNOWN][IEA] neuron projection regeneration [IEP] protein stabilization [UNKNOWN][IEA]
Molecular Function:	G-protein coupled receptor activity [IEA] non-G-protein coupled 7TM receptor activity [IEA] receptor activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
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    1 MAAGRPVRGP ELAPRRLLQL LLLVLLGGRG RGAALSGNVT GPGPRSAGGS ARRNAPVTSP  60
   61 PPPLLSHCGR AAHCEPLRYN VCLGSALPYG ATTTLLAGDS DSQEEAHSKL VLWSGLRNAP 120
  121 RCWAVIQPLL CAVYMPKCEN DRVELPSRTL CQATRGPCAI VERERGWPDF LRCTPDHFPE 180
  181 GCPNEVQNIK FNSSGQCEAP LVRTDNPKSW YEDVEGCGIQ CQNPLFTEAE HQDMHSYIAA 240
  241 FGAVTGLCTL FTLATFVADW RNSNRYPAVI LFYVNACFFV GSIGWLAQFM DGARREIVCR 300
  301 ADGTMRFGEP TSSETLSCVI IFVIVYYALM AGVVWFVVLT YAWHTSFKAL GTTYQPLSGK 360
  361 TSYFHLLTWS LPFVLTVAIL AVAQVDGDSV SGICFVGYKN YRYRAGFVLA PIGLVLIVGG 420
  421 YFLIRGVMTL FSIKSNHPGL LSEKAASKIN ETMLRLGIFG FLAFGFVLIT FSCHFYDFFN 480
  481 QAEWERSFRD YVLCQANVTI GLPTKKPIPD CEIKNRPSLL VEKINLFAMF GTGIAMSTWV 540
  541 WTKATLLIWR RTWCRLTGHS DDEPKRIKKS KMIAKAFSKR RELLQNPGQE LSFSMHTVSH 600
  601 DGPVAGLAFE LNEPSADVSS AWAQHVTKMV ARRGAILPQD VSVTPVATPV PPEEQANLWL 660
  661 VEAEISPELE KRLGRKKKRR KRKKEVCPLG PAPELHHSAP VPATSAVPRL PQLPRQKCLV 720
  721 AANAWGTGEP CRQGAWTVVS NPFCPEPSPH QDPFLPGASA PRVWAQGRLQ GLGSIHSRTN 780
  781 LMEAELLDAD SDF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: SMO_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: