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Protein Overview: IL12A_RAT

General Information:
Name(s) found: IL12A_RAT [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Interleukin-12 subunit alpha OS=Rattus norvegicus GN=Il12a PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 215 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN]
    extracellular region [IEA]
    interleukin-12 complex [UNKNOWN][IEA]
    Biological Process: cell cycle arrest [UNKNOWN][IEA]
    positive regulation of smooth muscle cell apoptosis [UNKNOWN][IEA]
    positive regulation of T cell proliferation [UNKNOWN][IEA]
    positive regulation of tyrosine phosphorylation of Stat4 protein [UNKNOWN][IEA]
    positive regulation of cell adhesion [UNKNOWN][IEA]
    response to virus [UNKNOWN][IEA]
    positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [UNKNOWN][IEA]
    defense response to protozoan [UNKNOWN]
    positive regulation of natural killer cell mediated cytotoxicity [UNKNOWN]
    immune response [IEA]
    positive regulation of lymphocyte proliferation [UNKNOWN]
    positive regulation of natural killer cell activation [UNKNOWN][IEA]
    positive regulation of interferon-gamma production [UNKNOWN][IEA]
    negative regulation of smooth muscle cell proliferation [UNKNOWN][IEA]
    response to lipopolysaccharide [UNKNOWN][IEA]
    positive regulation of T cell mediated cytotoxicity [UNKNOWN][IEA]
    cell migration [UNKNOWN][IEA]
    response to UV-B [UNKNOWN][IEA]
    defense response to Gram-positive bacterium [UNKNOWN][IEA]
    Molecular Function: growth factor activity [UNKNOWN][IEA]
    protein binding [UNKNOWN][IEA]
    protein heterodimerization activity [UNKNOWN][IEA]
    interleukin-12 beta subunit binding [UNKNOWN][IEA]
    interleukin-12 receptor binding [IEA]
    cytokine activity [UNKNOWN][IDA]
    interleukin-27 binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCQSRYLLFL ATLVLLNHLT SARVIPVSGP AKCLNQSQNL LKTTDDMVRT AREKLKHYSC  60
   61 TAGDIDHEDI TRDKTSTLEA CLPLELHKNE SCLATKETSS IIRGSCLPPQ KTSLMMTLCL 120
  121 GSIYEDLKMY QSEFQAINAA LQSHNHQQIT LDRNMLMAID ELMRSLNHSG ETLHQKAPMG 180
  181 EADPYRVKMK LCILLHAFST RVMTINRVMN YLSSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle