Protein Overview: CP27B_RAT

General Information:
Name(s) found:	CP27B_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|3182965\|sp\|O35132.2\|CP27B_RAT RecName: Full=25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; AltName: Full=Cytochrome P450 subfamily XXVIIB polypeptide 1; AltName: Full=Cytochrome p450 27B1; AltName: Full=Calcidiol 1-monooxygenase; AltName: Full [NCBI NR] gi\|2588995\|dbj\|BAA23271.1\| VD3 1a hydroxylase [Rattus norvegicus] [NCBI NR] gi\|16758598\|ref\|NP_446215.1\| cytochrome P450, family 27, subfamily b, polypeptide 1 [Rattus norvegicus] [NCBI NR] (O35132) 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (EC 1.14.13.13) (Calcidiol 1-monooxygenase) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha) [Swiss-Prot] 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial OS=Rattus norvegicus GN=Cyp27b1 PE=2 SV=2 [Swiss-Prot] Ensembl_locations(Chr-bp):None 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor [hmr_yeast5_DM3-1_pombe.fasta] cytochrome P450, subfamily 27b, polypeptide 1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1; cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydro [HMR_022704-rand.fasta] cytochrome P450, family 27, subfamily b, polypeptide 1 [Rattus norvegicus]gi\|3182965\|sp\|O35132\|CP2B_RAT 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (Calcidiol 1-monooxygenase) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-al [nrdb_11152004_Chlamydomonas] Tax_Id=10116 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_053763) cytochrome P450, subfamily 27b, polypeptide 1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome p450 27B1) (Calcidiol 1-monooxygenase) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxyl [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] cytochrome P450, family 27, subfamily b, polypeptide 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] VD3 1a hydroxylase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Cyp27b1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [rat-ipi-250309-contam.fasta] 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial OS=Rattus norvegicus GN=Cyp27b1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	501 amino acids
Gene Ontology:
Cellular Component:	mitochondrial membrane [IEA] cytoplasm [UNKNOWN] mitochondrion [UNKNOWN][IDA] membrane [IEA] cellular_component [ND]
Biological Process:	response to vitamin D [UNKNOWN][IDA] response to estrogen stimulus [UNKNOWN] calcium ion homeostasis [UNKNOWN] response to prostaglandin E stimulus [IDA] negative regulation of cell proliferation [UNKNOWN] response to cAMP [IDA] lactation [IEP] decidualization [UNKNOWN] vitamin D metabolic process [UNKNOWN][IDA][TAS] response to insulin stimulus [IDA] negative regulation of calcidiol 1-monooxygenase activity [UNKNOWN] negative regulation of cell growth [UNKNOWN] calcium ion transport [UNKNOWN] positive regulation of vitamin D receptor signaling pathway [UNKNOWN] regulation of bone mineralization [UNKNOWN] positive regulation of keratinocyte differentiation [UNKNOWN] bone mineralization [UNKNOWN] response to interferon-gamma [UNKNOWN] response to copper ion [IDA] aging [IDA] vitamin D biosynthetic process [UNKNOWN] response to peptide hormone stimulus [IEP] vitamin D catabolic process [IDA] response to drug [IDA] response to calcium ion [IEP] G1 to G0 transition [UNKNOWN] response to lipopolysaccharide [UNKNOWN] oxidation reduction [IEA] positive regulation of vitamin D 24-hydroxylase activity [UNKNOWN] response to tumor necrosis factor [UNKNOWN]
Molecular Function:	metal ion binding [IEA] electron carrier activity [IEA] calcidiol 1-monooxygenase activity [UNKNOWN][IDA][TAS] monooxygenase activity [IEA] heme binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQAVKLASR VFHRVQLPSQ LGSDSVLRSL SDIPGPSTPS FLAELFCKGG LSRLHELQVH  60
   61 GAARYGPIWS GSFGTLRTVY VADPALVEQL LRQESHCPER CSFSSWSEHR RRHQRACGLL 120
  121 TADGEEWQRL RSLLAPLLLR PQAAAGYAGT LDSVVSDLVR RLRRQRGRGS GLPDLVLDVA 180
  181 GEFYKFGLEG IGAVLLGSRL GCLEAEVPPD TETFIEAVGS VFVSTLLTMA MPSWLHRLIP 240
  241 GPWARLCRDW DQMFAFAQKH VEQREGEAAV RNQGKPEEDL PTGHHLTHFL FREKVSVQSI 300
  301 VGNVTELLLA GVDTVSNTLS WALYELSRHP EVQSALHSEI TGAVNPGSYA HLQATALSQL 360
  361 PLLKAVIKEV LRLYPVVPGN SRVPDRDICV GNYVIPQDTL VSLCHYATSR DPAQFREPNS 420
  421 FNPARWLGEG PAPHPFASLP FGFGKRSCIG RRLAELELQM ALAQILTHFE VLPEPGALPV 480
  481 KPMTRTVLVP ERSIHLQFVD R

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.79

Protein Overview: CP27B_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: