Protein Overview: E2K1_RAT, E2AK1_RAT

General Information:
Name(s) found:	E2K1_RAT [Swiss-Prot] E2AK1_RAT [Swiss-Prot]
Description(s) found: Found 19 descriptions. SHOW ALL	(Q63185) Eukaryotic translation initiation factor 2 alpha kinase 1 (EC 2.7.1.37) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor-2 a [Swiss-Prot] Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Rattus norvegicus GN=Eif2ak1 PE=2 SV=1 [Swiss-Prot]
Organism:	Rattus norvegicus
Length:	620 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [ISS]
Biological Process:	regulation of translation [UNKNOWN] response to external stimulus [UNKNOWN][ISS] negative regulation of translational initiation [TAS] regulation of eIF2 alpha phosphorylation by heme [UNKNOWN][IEA] negative regulation of cell proliferation [ISS] protoporphyrinogen IX metabolic process [UNKNOWN][IEA] protein amino acid autophosphorylation [UNKNOWN][ISS] negative regulation of hemoglobin biosynthetic process [ISS] regulation of hemoglobin biosynthetic process [UNKNOWN] translational initiation [TAS] protein amino acid phosphorylation [TAS] response to stress [UNKNOWN][ISS]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] protein homodimerization activity [ISS] protein kinase activity [UNKNOWN][IDA] eukaryotic translation initiation factor 2alpha kinase activity [UNKNOWN][IDA][ISS] transferase activity [IEA] heme binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGGGSVDGE RDTDDDAAGA VAAPPAIDFP AEVSDPKYDE SDVPAELQVF KEPLQQPTFP  60
   61 FLVANQLLLV SLLEHLSHVH EPNPLHSKQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 120
  121 NRAITHLMRS AKERVRQDPC QDNSYMQKIR SREIALEAQT SRYLNEFEEL AILGKGGYGR 180
  181 VYKVRNKLDG QHYAIKKILI KSATKTDCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVL 240
  241 QPQDRVPIQL PSLEVLSEHE GDRNQGGVKD NESSSSIIFA ELTPEKENPL AESDVKNENN 300
  301 NLVSYRANLV IRSSSESESS IELQEDGLNE SPLRPVVKHQ LPLGHSSDVE GNFTSTDESS 360
  361 EDNLNLLGQT EARYHLMLHI QMQLCELSLW DWIAERNKRS RKCVDEAACP YVMASVATKI 420
  421 FQELVEGVFY IHNMGIVHRD LKPRNIFLHG PDQQVKIGDF GLACADIIQK SADWTNRNGK 480
  481 GTPTHTSRVG TCLYASPEQL EGSEYDAKSD MYSLGVILLE LFQPFGTEME RATVLTGVRT 540
  541 GRIPESLSKR CPVQAKYIQL LTGRNAAQRP SALQLLQSEL FQTTGNVNLT LQMKIMEQEK 600
  601 EIEELKKQLS LLSQDKGLKR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: E2K1_RAT, E2AK1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: