Protein Overview: AT1A1_RAT

General Information:
Name(s) found:	AT1A1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|A24639 Na+/K+-exchanging ATPase (EC 3.6.3.9) alpha-1 chain [validated] - rat [NCBI NR] gi\|6978543\|ref\|NP_036636.1\| Na+/K+ -ATPase alpha 1 subunit [Rattus norvegicus] [NCBI NR] gi\|55772\|emb\|CAA29306.1\| sodium/potassium-transporting ATPase alpha-1 chain precursor [Rattus norvegicus] [NCBI NR] gi\|38303881\|gb\|AAH61968.1\| ATPase, Na+/K+ transporting, alpha 1 polypeptide [Rattus norvegicus] [NCBI NR] gi\|203027\|gb\|AAA40775.1\| (Na+ and K+) ATPase, alpha catalytic subunit precursor [NCBI NR] gi\|114376\|sp\|P06685.1\|AT1A1_RAT RecName: Full=Sodium/potassium-transporting ATPase subunit alpha-1; Short=Sodium pump subunit alpha-1; AltName: Full=Na(+)/K(+) ATPase alpha-1 subunit; Flags: Precursor [NCBI NR] Sodium/potassium-transporting ATPase subunit alpha-1 OS=Rattus norvegicus GN=Atp1a1 PE=1 SV=1 [Swiss-Prot] (P06685) Sodium/potassium-transporting ATPase alpha-1 chain precursor (EC 3.6.3.9) (Sodium pump 1) (Na+/K+ ATPase 1) [Swiss-Prot] Ensembl_locations(Chr-bp):2-191534323;2-191543873 Sodium/potassium-transporting ATPase alpha-1 chain precursor [hmr_yeast5_DM3-1_pombe.fasta] ATPase, Na+K+ transporting, alpha 1; ATPase Na+K+ transporting alpha 1 polypeptide [HMR_022704-rand.fasta] ATPase, Na+/K+ transporting, alpha 1 polypeptide [Rattus norvegicus]gi\|38303881\|gb\|AAH61968.1\| ATPase, Na+/K+ transporting, alpha 1 polypeptide [Rattus norvegicus]gi\|55772\|emb\|CAA29306.1\| sodium/potassium-transporting ATPase alpha-1 chain precursor [Rat [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Sodium/potassium-transporting ATPase alpha-1 chain precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_012504) ATPase, Na+K+ transporting, alpha 1 polypeptide [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Sodium/potassium-transporting ATPase subunit alpha-1 precursor (Sodium pump subunit alpha-1) (Na(+)/K(+) ATPase alpha-1 subunit) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ATPase, Na+/K+ transporting, alpha 1 polypeptide [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] sodium/potassium-transporting ATPase alpha-1 chain precursor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] (Na+ and K+) ATPase, alpha catalytic subunit precursor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SODIUM/POTASSIUM-TRANSPORTING ATPASE ALPHA-1 CHAIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Na+/K+ -ATPase alpha 1 subunit [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Sodium/potassium-transporting ATPase alpha-1 chain precursor (Sodium pump 1) (Na+/K+ ATPase 1) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 [rat-ipi-250309-contam.fasta] Sodium/potassium-transporting ATPase subunit alpha-1 OS=Rattus norvegicus GN=Atp1a1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1023 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] caveola [IDA] endosome [IDA] melanosome [IEA] sarcolemma [UNKNOWN] membrane [IEA] microsome [UNKNOWN] integral to membrane [ISS] sodium:potassium-exchanging ATPase complex [IDA][NAS] basolateral plasma membrane [UNKNOWN] plasma membrane [UNKNOWN]
Biological Process:	metabolic process [IEA] ATP catabolic process [TAS] ATP biosynthetic process [IEA] positive regulation of heart contraction [UNKNOWN] regulation of blood pressure [UNKNOWN] positive regulation of striated muscle contraction [UNKNOWN] negative regulation of heart contraction [UNKNOWN] regulation of the force of heart contraction [UNKNOWN] potassium ion transport [IDA] sodium ion transport [IDA] negative regulation of glucocorticoid biosynthetic process [UNKNOWN] response to drug [UNKNOWN] potassium ion import [IDA] energy coupled proton transport, against electrochemical gradient [TAS]
Molecular Function:	protein domain specific binding [IPI] sodium:potassium-exchanging ATPase activity [UNKNOWN][IDA] monovalent inorganic cation transmembrane transporter activity [IEA] ADP binding [IDA] nucleotide binding [IEA] ATP binding [IDA] protein binding [UNKNOWN][IPI] potassium ion binding [IDA] metal ion binding [IEA] 4-nitrophenylphosphatase activity [UNKNOWN] sodium ion binding [IDA] hydrolase activity [IEA] hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKGVGRDKY EPAAVSEHGD KKSKKAKKER DMDELKKEVS MDDHKLSLDE LHRKYGTDLS  60
   61 RGLTPARAAE ILARDGPNAL TPPPTTPEWV KFCRQLFGGF SMLLWIGAIL CFLAYGIRSA 120
  121 TEEEPPNDDL YLGVVLSAVV IITGCFSYYQ EAKSSKIMES FKNMVPQQAL VIRNGEKMSI 180
  181 NAEDVVVGDL VEVKGGDRIP ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR 240
  241 NIAFFSTNCV EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAEEIEH FIHLITGVAV 300
  301 FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN 360
  361 LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTENQSGVS FDKTSATWFA 420
  421 LSRIAGLCNR AVFQANQENL PILKRAVAGD ASESALLKCI EVCCGSVMEM REKYTKIVEI 480
  481 PFNSTNKYQL SIHKNPNASE PKHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN 540
  541 AYLELGGLGE RVLGFCHLLL PDEQFPEGFQ FDTDEVNFPV DNLCFVGLIS MIDPPRAAVP 600
  601 DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVNQVNPRDA 660
  661 KACVVHGSDL KDMTSEELDD ILRYHTEIVF ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN 720
  721 DSPALKKADI GVAMGIVGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL 780
  781 TSNIPEITPF LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK 840
  841 TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP FHLLGIRETW DDRWINDVED 900
  901 SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK NKILIFGLFE 960
  961 ETALAAFLSY CPGMGAALRM YPLKPTWWFC AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE1020
 1021 TYY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: AT1A1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: