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Protein Overview: ISL1_RAT

General Information:
Name(s) found: ISL1_RAT [Swiss-Prot]
Description(s) found:
Found 20 descriptions.
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  • Insulin gene enhancer protein ISL-1 OS=Rattus norvegicus GN=Isl1 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 349 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    intracellular part [UNKNOWN][IEA]
    intracellular [UNKNOWN]
    Biological Process: retinal ganglion cell axon guidance [UNKNOWN][IEA]
    multicellular organismal development [IEA]
    neuron differentiation [UNKNOWN]
    spinal cord motor neuron differentiation [UNKNOWN]
    negative regulation of neuron differentiation [UNKNOWN][IEA]
    regulation of transcription, DNA-dependent [IDA]
    visceral motor neuron differentiation [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    pituitary gland development [UNKNOWN][IEA]
    heart development [UNKNOWN]
    heart morphogenesis [UNKNOWN][IEA]
    neural crest cell migration [UNKNOWN][IEA]
    neuron fate commitment [UNKNOWN][IEA]
    mesenchymal cell differentiation [UNKNOWN][IEA]
    positive regulation of insulin secretion [IMP]
    axon regeneration [IEP]
    pancreas development [UNKNOWN][IEA]
    Molecular Function: transcription factor activity [IEA]
    zinc ion binding [IEA]
    protein binding [IDA]
    transcription regulator activity [IMP]
    metal ion binding [IEA]
    sequence-specific DNA binding [IDA]
    chromatin binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ YLDESCTCFV  60
   61 RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY HIECFRCVAC SRQLIPGDEF 120
  121 ALREDGLFCR ADHDVVERAS LGAGDPLSPL HPARPLQMAA EPISARQPAL RPHVHKQPEK 180
  181 TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS 240
  241 IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 300
  301 SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle