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Protein Overview: FAS_RAT

General Information:
Name(s) found: FAS_RAT [Swiss-Prot]
Description(s) found:
Found 15 descriptions.
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  • Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 2505 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDA]
    cytoplasm [UNKNOWN][IEA]
    melanosome [IEA]
    mitochondrion [UNKNOWN]
    cytosol [UNKNOWN]
    Golgi apparatus [UNKNOWN]
    glycogen granule [UNKNOWN]
    cellular_component [ND]
    Biological Process: acetyl-CoA metabolic process [IDA]
    lipid biosynthetic process [TAS]
    oxidation reduction [IEA]
    fatty acid biosynthetic process [IMP]
    Molecular Function: hydrolase activity, acting on ester bonds [IEA]
    zinc ion binding [IEA]
    identical protein binding [IPI]
    protein homodimerization activity [IDA]
    drug binding [IDA]
    lyase activity [IEA]
    oleoyl-[acyl-carrier-protein] hydrolase activity [UNKNOWN][IEA]
    acyl carrier activity [IEA]
    [acyl-carrier-protein] S-acetyltransferase activity [UNKNOWN][IEA]
    fatty acid synthase activity [IDA][IMP]
    3-oxoacyl-[acyl-carrier-protein] synthase activity [UNKNOWN][IEA]
    3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [UNKNOWN]
    [acyl-carrier-protein] S-malonyltransferase activity [UNKNOWN][IEA]
    3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [IEA]
    3-oxoacyl-[acyl-carrier-protein] reductase activity [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [UNKNOWN][IEA]
    oxidoreductase activity [IEA]
    cofactor binding [IEA]
    NADPH binding [IDA]
    phosphopantetheine binding [IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEVVIAGMS GKLPESENLQ EFWANLIGGV DMVTDDDRRW KAGLYGLPKR SGKLKDLSKF  60
   61 DASFFGVHPK QAHTMDPQLR LLLEVSYEAI VDGGINPASL RGTNTGVWVG VSGSEASEAL 120
  121 SRDPETLLGY SMVGCQRAMM ANRLSFFFDF KGPSIALDTA CSSSLLALQN AYQAIRSGEC 180
  181 PAAIVGGINL LLKPNTSVQF MKLGMLSPDG TCRSFDDSGN GYCRAEAVVA VLLTKKSLAR 240
  241 RVYATILNAG TNTDGCKEQG VTFPSGEAQE QLIRSLYQPG GVAPESLEYI EAHGTGTKVG 300
  301 DPQELNGITR SLCAFRQSPL LIGSTKSNMG HPEPASGLAA LTKVLLSLEN GVWAPNLHFH 360
  361 NPNPEIPALL DGRLQVVDRP LPVRGGIVGI NSFGFGGANV HVILQPNTQQ APAPAPHAAL 420
  421 PHLLHASGRT MEAVQGLLEQ GRQHSQDLAF VSMLNDIAAT PTAAMPFRGY TVLGVEGHVQ 480
  481 EVQQVPASQR PLWFICSGMG TQWRGMGLSL MRLDSFRESI LRSDEALKPL GVKVSDLLLS 540
  541 TDEHTFDDIV HSFVSLTAIQ IALIDLLTSM GLKPDGIIGH SLGEVACGYA DGCLSQREAV 600
  601 LAAYWRGQCI KDANLPAGSM AAVGLSWEEC KQRCPPGVVP ACHNSEDTVT ISGPQAAVNE 660
  661 FVEQLKQEGV FAKEVRTGGL AFHSYFMEGI APTLLQALKK VIREPRPRSA RWLSTSIPEA 720
  721 QWQSSLARTS SAEYNVNNLV SPVLFQEALW HVPEHAVVLE IAPHALLQAV LKRGVKPSCT 780
  781 IIPLMKRDHK DNLEFFLTNL GKVHLTGIDI NPNALFPPVE FPVPRGTPLI SPHIKWDHSQ 840
  841 TWDIPVAEDF PNGSSSSSAT VYNIDASSES SDHYLVDHCI DGRVLFPGTG YLYLVWKTLA 900
  901 RSLSLSLEET PVVFENVTFH QATILPRTGT VPLEVRLLEA SHAFEVSDSG NLIVSGKVYQ 960
  961 WEDPDSKLFD HPEVPIPAES ESVSRLTQGE VYKELRLRGY DYGPHFQGVY EATLEGEQGK1020
 1021 LLWKDNWVTF MDTMLQISIL GFSKQSLQLP TRVTAIYIDP ATHLQKVYML EGDTQVADVT1080
 1081 TSRCLGVTVS GGVYISRLQT TATSRRQQEQ LVPTLEKFVF TPHVEPECLS ESAILQKELQ1140
 1141 LCKGLAKALQ TKATQQGLKM TVPGLEDLPQ HGLPRLLAAA CQLQLNGNLQ LELGEVLARE1200
 1201 RLLLPEDPLI SGLLNSQALK ACIDTALENL STLKMKVVEV LAGEGHLYSH ISALLNTQPM1260
 1261 LQLEYTATDR HPQALKDVQT KLQQHDVAQG QWDPSGPAPT NLGALDLVVC NCALATLGDP1320
 1321 ALALDNMVAA LKDGGFLLMH TVLKGHALGE TLACLPSEVQ PGPSFLSQEE WESLFSRKAL1380
 1381 HLVGLKKSFY GTALFLCRRL SPQDKPIFLP VEDTSFQWVD SLKSILATSS SQPVWLTAMN1440
 1441 CPTSGVVGLV NCLRKEPGGH RIRCILLSNL SSTSHVPKLD PGSSELQKVL ESDLVMNVYR1500
 1501 DGAWGAFRHF QLEQDKPEEQ TAHAFVNVLT RGDLASIRWV SSPLKHMQPP SSSGAQLCTV1560
 1561 YYASLNFRDI MLATGKLSPD AIPGKWASRD CMLGMEFSGR DKCGRRVMGL VPAEGLATSV1620
 1621 LLSPDFLWDV PSSWTLEEAA SVPVVYTTAY YSLVVRGRIQ HGETVLIHSG SGGVGQAAIS1680
 1681 IALSLGCRVF TTVGSAEKRA YLQARFPQLD DTSFANSRDT SFEQHVLLHT GGKGVDLVLN1740
 1741 SLAEEKLQAS VRCLAQHGRF LEIGKFDLSN NHPLGMAIFL KNVTFHGILL DALFEGANDS1800
 1801 WREVAELLKA GIRDGVVKPL KCTVFPKAQV EDAFRYMAQG KHIGKVLVQV REEEPEAMLP1860
 1861 GAQPTLISAI SKTFCPEHKS YIITGGLGGF GLELARWLVL RGAQRLVLTS RSGIRTGYQA1920
 1921 KHVREWRRQG IHVLVSTSNV SSLEGARALI AEATKLGPVG GVFNLAMVLR DAMLENQTPE1980
 1981 LFQDVNKPKY NGTLNLDRAT REACPELDYF VAFSSVSCGR GNAGQSNYGF ANSTMERICE2040
 2041 QRRHDGLPGL AVQWGAIGDV GIILEAMGTN DTVVGGTLPQ RISSCMEVLD LFLNQPHAVL2100
 2101 SSFVLAEKKA VAHGDGEAQR DLVKAVAHIL GIRDLAGINL DSSLADLGLD SLMGVEVRQI2160
 2161 LEREHDLVLP IREVRQLTLR KLQEMSSKAG SDTELAAPKS KNDTSLKQAQ LNLSILLVNP2220
 2221 EGPTLTRLNS VQSSERPLFL VHPIEGSITV FHSLAAKLSV PTYGLQCTQA APLDSIPNLA2280
 2281 AYYIDCIKQV QPEGPYRVAG YSFGACVAFE MCSQLQAQQG PAPAHNNLFL FDGSHTYVLA2340
 2341 YTQSYRAKLT PGCEAEAEAE AICFFIKQFV DAEHSKVLEA LLPLKSLEDR VAAAVDLITR2400
 2401 SHQSLDRRDL SFAAVSFYYK LRAADQYKPK AKYHGNVILL RAKTGGTYGE DLGADYNLSQ2460
 2461 VCDGKVSVHI IEGDHRTLLE GRGLESIINI IHSSLAEPRV SVREG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

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