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Protein Overview: WNK1_RAT

General Information:
Name(s) found: WNK1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|8272557|gb|AAF74258.1|AF227741_1 protein kinase WNK1 [Rattus norvegicus] [NCBI NR]
  • gi|41688742|sp|Q9JIH7.1|WNK1_RAT RecName: Full=Serine/threonine-protein kinase WNK1; AltName: Full=Protein kinase with no lysine 1; AltName: Full=Protein kinase, lysine-deficient 1 [NCBI NR]
  • gi|16758634|ref|NP_446246.1| WNK lysine deficient protein kinase 1 [Rattus norvegicus] [NCBI NR]
  • Serine/threonine-protein kinase WNK1 OS=Rattus norvegicus GN=Wnk1 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):4-161916772 Protein kinase WNK1 [hmr_yeast5_DM3-1_pombe.fasta]
  • protein kinase, lysine deficient 1 [HMR_022704-rand.fasta]
  • protein kinase, lysine deficient 1 [Rattus norvegicus]gi|8272557|gb|AAF74258.1| protein kinase WNK1 [Rattus norvegicus]gi|41688742|sp|Q9JIH7|WNK1_RAT Serine/threonine-protein kinase WNK1 (Protein kinase with no lysine 1) (Protein kinase, lysine-deficien [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Serine/threonine-protein kinase WNK1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_053794) protein kinase, lysine deficient 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Serine/threonine-protein kinase WNK1 (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • WNK lysine deficient protein kinase 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • protein kinase WNK1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SERINE/THREONINE-PROTEIN KINASE WNK1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • protein kinase, lysine deficient 1 [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Wnk1 Serine/threonine-protein kinase WNK1 [rat-ipi-250309-contam.fasta]
    • Organism: Rattus norvegicus
    Length: 2126 amino acids

    Gene Ontology:
    Cellular Component: insoluble fraction [IDA]
    soluble fraction [UNKNOWN]
    cytoplasm [UNKNOWN][IDA]
    vesicular fraction [UNKNOWN]
    Biological Process: ion transport [ISS]
    regulation of cellular process [ISS]
    positive regulation of systemic arterial blood pressure [UNKNOWN]
    protein amino acid autophosphorylation [IDA]
    intracellular protein kinase cascade [UNKNOWN][IDA]
    negative regulation of kinase activity [IDA]
    protein amino acid phosphorylation [UNKNOWN][IDA][IEA]
    Molecular Function: nucleotide binding [IEA]
    magnesium ion binding [IMP]
    ATP binding [UNKNOWN][IDA][IEA]
    protein serine/threonine kinase inhibitor activity [IDA]
    protein binding [UNKNOWN][IPI]
    potassium channel inhibitor activity [IDA]
    protein kinase activity [UNKNOWN]
    protein serine/threonine kinase activity [UNKNOWN][IDA][IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDGTAEKQS GTPGFLSPPA PVPKNGSSSD SSVGEKLGAA VADSGIGRTE EYRRRRHTMD  60
   61 KDSRGAAATT TPTEHRFFRR SVICDSNATA LELPGLPLSI PQPSVPAVVP QSAPPEPHRE 120
  121 ETLTATVASQ VSQQPSAAAS PGEQAVVGSA TATVPSSTSK DRPVSQPSLV GSKEEPPPSR 180
  181 SGSGSGGASA KEPQEERNQQ QDDIEELETK AVGMSNDGRF LKFDIEIGRG SFKTVYKGLD 240
  241 TETTVEVAWC ELQDRKLTKS ERQRFKEEAE MLKGLQHPNI VRFYDSWEST VKGKKCIVLV 300
  301 TELMTSGTLK TYLKRFKVMK IKVLRSWCRQ ILKGLQFLHT RTPPIIHRDL KCDNIFITGP 360
  361 TGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD ESVDVYAFGM CMLEMATSEY 420
  421 PYSECQNAAQ IYRRVTSGVK PASFDKVAIP EVKEIIEGCI RQNKDERYSI KDLLNHAFFQ 480
  481 EETGVRVELA EEDDGEKIAI KLWLRIEDIK KLKGKYKDNE AIEFSFDLER DVPEDVAQEM 540
  541 VESGYVCEGD HKTMAKAIKD RVSLIKRKRE QRQLVREEQE KRKQEESSFK QQNEQQASVS 600
  601 QAGIQPLSVA STGIPTAPTT SASVSTQVEP EEPEADQHQQ LQYQQPSISV LSDGTVDSGQ 660
  661 GSSVFTESRV SSQQTVSYGS QHEQAHSIGT APGHTVSSIQ AQSQPHGVYP PSSMAQGQNQ 720
  721 GQPSSSLAGV LSSQPVQHPQ QQGIQPTVPP QQAVQYSLPQ AASSSEGTVQ PVSQPQVSAG 780
  781 TQSSTQGVSQ AAPPEQTPIT QSQPTQPVPL VSSVDSAHSD VASGMSDGNE NAPSSSGRHE 840
  841 GRTTKRHYRK SVRSRSRHEK TSRPKLRILN VSNKGDRVVE CQLETHNRKM VTFKFDLDGD 900
  901 NPEEIATIMV NNDFILAIER ESFVAQVREI IEKADEMLSE DVSVEPEGDQ GLESLQGKDD 960
  961 YGFPGSQKLE GEFKQPIAVS SMPQQIGVPT SSLTQVVHSA GRRFIVSPVP ESRLRESKIF1020
 1021 TSEIPDPVAA STSQGPGMNL SHSASSLSLQ QAFSELKHGQ MTEGPNTAPP NFNHPGPTFS1080
 1081 PFLTSIAGVQ TVAASTPSVS VPITSSPLND ISTSVMQSEG ALPTDKGIGG VTTSTGVVAS1140
 1141 GGLTTLSVSE TPTLSSAVSS STAPAVVTVS TTSQPVQAFT SGSIASSTGS FPSGTFSTTT1200
 1201 GTTVSSVAVP NAKPPTVLLQ QVAGNTAGVA IVTSVSTTTP FPAMASQPSL PLGSSTSAPT1260
 1261 LAETVVVSAH SLDKASHSST AGLGLSFCAP SSSSSSGTAV SSSVSQPGIV HPLVISSAIA1320
 1321 STPVLPQPAV PTSTPLLPQV PNIPPLVQPV ANVPAVQQTL IHSQPQPALL PNQPHTHCPE1380
 1381 MDADTQSKAP GIDDIKTLEE KLRSLFSEHS SSGTQHASVS LETPLVVETV TPGIPTTAVA1440
 1441 PSKLMTSTTS TCLPPTNLPL GTAGMPVMPV GTPGQVSTPG THASAPASTA TGAKPGTTPP1500
 1501 KPSLTKTVVP PVGTELSAGT VPCEQLPPFP GPSLIQTQQP LEDLDAQLRR TLSPETIPVT1560
 1561 PAVGPLSTMS STAVTEAGSQ PQKDGTEVHV TASSSGAGVV KMGRFQVSVT MDDAQKERKN1620
 1621 RSEDTKSVHF ESSTSESSVL SSSSPESTLV KPEPNGITVS GISLDVPDST HRTPTPEAKS1680
 1681 ETGQPTKVGR FQVTTTANKV GRFSVSRTED KVTELKKEGP VTSPFRDSEQ TVIPAAIPKK1740
 1741 EKPELAEPSH LNGPSSDLEA AFLSRGGEDG SGSPHSPPHL CSKSLPIQTL SQSLSNSFNS1800
 1801 SYMSSDNESD IEDEDLRLEL RRLREKHLKE IQDLQSRQKH EIESLYTKLG KVPPAVIIPP1860
 1861 AAPLSGRRRR PTKSKGSKSS RSSSLGNKSP QLSGNLSGQS GTSVLNPQQT LHPPGNTPET1920
 1921 GHNQLLQPLK PSPSSDNLYS AFTSDGAISI PSLSAPGQGT SSTNTVGGTV SSQAAQAQPP1980
 1981 AMTSSRKGTF TDDLHKLVDN WARDAMNLSG RRGSKGHMNY EGPGMARKFS APGQLCISMT2040
 2041 SNMGGSTPIS AASATSLGHF TKSMCPPQQY GFPAAPFGTQ WSGTGGPAPQ PLGQFQPVGT2100
 2101 TSLQNFNISN LQKSISNPPS SNLRTT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle