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Protein Overview: PLCE1_RAT

General Information:
Name(s) found: PLCE1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|81872439|sp|Q99P84.1|PLCE1_RAT RecName: Full=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1; AltName: Full=Phospholipase C-epsilon-1; Short=PLC-epsilon-1; AltName: Full=Phosphoinositide-specific phospholipase C epsilon-1 [NCBI NR]
  • gi|16758594|ref|NP_446210.1| phospholipase C, epsilon 1 [Rattus norvegicus] [NCBI NR]
  • gi|12744799|gb|AAK06775.1|AF323615_1 phosphoinositide-specific phospholipase C epsilon [Rattus norvegicus] [NCBI NR]
  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 OS=Rattus norvegicus GN=Plce1 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):1-263230300 Phosphoinositide-specific phospholipase C epsilon [hmr_yeast5_DM3-1_pombe.fasta]
  • phospholipase C, epsilon 1; phospholipase C epsilon 1; phospholipase C epsilon [HMR_022704-rand.fasta]
  • phospholipase C, epsilon 1 [Rattus norvegicus]gi|12744799|gb|AAK06775.1| phosphoinositide-specific phospholipase C epsilon [Rattus norvegicus] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Phosphoinositide-specific phospholipase C epsilon [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_053758) phospholipase C, epsilon; phospholipase C, epsilon 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 (Phospholipase C-epsilon-1) (PLC-epsilon-1) (Phosphoinositide-specific phospholipase C epsilon-1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • phospholipase C, epsilon 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • phosphoinositide-specific phospholipase C epsilon [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Plce1 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 [rat-ipi-250309-contam.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 OS=Rattus norvegicus GN=Plce1 [011711_HMR.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 OS=Rattus norvegicus GN=Plce1 PE=1 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 2281 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN][ISS]
    cytoplasm [IEA]
    cytosol [UNKNOWN][ISS]
    Golgi membrane [IEA]
    Golgi apparatus [IEA]
    cellular_component [ND]
    intracellular [IEA]
    plasma membrane [UNKNOWN][ISS]
    Biological Process: activation of MAPK activity [UNKNOWN][ISS]
    glomerulus development [UNKNOWN]
    regulation of protein kinase activity [UNKNOWN][ISS]
    G-protein coupled receptor protein signaling pathway [IMP]
    signal transduction [IEA]
    small GTPase mediated signal transduction [IEA]
    lipid metabolic process [IEA]
    lipid catabolic process [IEA]
    regulation of Ras protein signal transduction [UNKNOWN][ISS]
    Ras protein signal transduction [IDA]
    activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger [UNKNOWN][ISS]
    regulation of G-protein coupled receptor protein signaling pathway [UNKNOWN][ISS]
    Molecular Function: phosphoinositide phospholipase C activity [UNKNOWN][IDA][IEA][ISS]
    protein binding [UNKNOWN]
    phospholipase C activity [UNKNOWN][ISS]
    calcium ion binding [IEA]
    guanyl-nucleotide exchange factor activity [IEA]
    signal transducer activity [IEA]
    Ras GTPase binding [IDA]
    hydrolase activity [IEA]
    enzyme binding [UNKNOWN][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSEEMAASF LIPVPQRKVA SAQSVAEERG EKVSEAGIPK TRAGRQGGLT PRTISQRNEP  60
   61 EEESPRTDFS QVFSIARGEL DSDENHNERC WEENVPGSTK NHAVNCNSLL QSHQHALPPS 120
  121 QLCEVCDSVT EEHLCLQPGI PSPLERKVFP GIELEMEDSP MDVSPLGNQP GIMESSGPHS 180
  181 DRNMAVFHFH YAGDRTMPGA FHTLSEKFIL DDCANCVTLP GGQQNKNYMA YTCKLVELTR 240
  241 TCGSKNGQLK CDHCTSLRDE YLCFESSCRK AEALSSGGGF CEDGFTHGPS AKTFLNPLEE 300
  301 FSDNCEDVDD IFKGKKERST LLVRRFCKND REVKKSVYTG TRAIVRTLPS GHIGLAAWSY 360
  361 VDQKKAGLMW PCGNGMRPLS TVDVRQSGRQ RLSEAQWCLI YSAVRREETE DTVGSLLHCS 420
  421 TQLPTPDTAH GRIGDGPCLK QCVRDSECEY RATLQRTSIA QYITGSLLEA TTSLGARSSL 480
  481 LSSFGGSTGR IMLKERQPGT SMANSSPVPS SSAGISKELI DLQPLIQFPE EVASILTEQE 540
  541 QNIYRRVLPM DYLCFLTRDL SSPECQRSLP RLKACISESI LMSQSGEHNA LEDLVMRFNE 600
  601 VSSWVTWLIL TAGSMEEKRE VFSYLVHVAK CCWNMGNYNA VMEFLAGLRS RKVLKMWQFM 660
  661 DQSDIETMRS LKDAMAQHES SVEYKKVVTR ALHIPGCKVV PFCGVFLKEL CEVLDGASGL 720
  721 LKLCPRYSSQ EEALEFVADY SGQDNFLQRV GQNGLKNPEK ELTVNSIFQI IRSCSRSLET 780
  781 EDEESASEGS GSRKNSLKDK TRWQFIIGDL LDSDNDIFEK SKECDPHGSE ESQKAFDHGT 840
  841 ELIPWYVLSI QADVHQFLLQ GATVIHYDQD THLSARCFLQ LQPDNSTLTW MKPPTASPAG 900
  901 ARLKLGVLSN VAEPGKFPSL GNAGVSGLVE GILDLFSVKA VYMGHPGIDI HTVCVQNKLS 960
  961 SMLLSETGVT LLYGLQTTDN RLLHFVAPKH TAKMLFSGLL ELTTAVRKIR KFPDQRQQWL1020
 1021 RKQYVSFYQE DGRYEGPTLA HAVELFGGRR WSTRNPSPGM SAKNAEKPNM QRNNTLGIST1080
 1081 TKKKKKMLMR GESGEVTDDE MATRKAKMYR ECRSRSGSDP QEANEQEDSE ANVITNPPNP1140
 1141 LHSRRAYSLT TAGSPNLATG MSSPISAWSS SSWHGRIKGG MKGFQSFMVS DSNMSFIEFV1200
 1201 ELFKSFSIRS RKDLKDIFDI YSVPCNRSAS ESTPLYTNLT IEENTNDLQP DLDLLTRNVS1260
 1261 DLGLFMKSKQ QLSDNQRQIS DAIAAASIVT NGTGIESTSL GIFGVGILQL NDFLVNCQGE1320
 1321 HCTYDEILSI IQKFEPNISM CHQGLLSFEG FARFLMDKDN FASKNDESRE NKKDLQLPLS1380
 1381 YYYIESSHNT YLTGHQLKGE SSVELYSQVL LQGCRSIELD CWDGDDGMPI IYHGHTLTTK1440
 1441 IPFKEVVEAI DRSAFITSDL PIIISIENHC SLPQQRKMAE IFKSVFGEKL VAKFLFETDF1500
 1501 SDDPMLPSPD QLRRKVLLKN KKLKAHQTPV DILKQKAHQL ASMQTQAFTG GNANPPPASN1560
 1561 EEEEDEEDEY DYDYESLSDD NILEDRPENK SCADKLQFEY NEEVPKRIKK ADNSSGNKGK1620
 1621 VYDMELGEEF YLPQNKKESR QIAPELSDLV IYCQAVKFPG LSTLNSSGSG RGKERKSRKS1680
 1681 IFGNNPGRMS PGETASFNRT SGKSSCEGIR QIWEEPPLSP NTSLSAIIRT PKCYHISSLN1740
 1741 ENAAKRLCRR YSQKLIQHTA CQLLRTYPAA TRIDSSNPNP LMFWLHGIQL VALNYQTDDL1800
 1801 PLHLNAAMFE ANGGCGYVLK PPVLWDKSCP MYQKFSPLER DLDAMDPATY SLTIISGQNV1860
 1861 CPSNSTGSPC IEVDVLGMPL DSCHFRTKPI HRNTLNPMWN EQFLFRVHFE DLVFLRFAVV1920
 1921 ENNSSAITAQ RIIPLKALKR GYRHLQLRNL HNEILEISSL FINSRRMEDN PSGSTRPASL1980
 1981 MFNTEERKCS QTHKVTVHGV PGPEPFAVFT INEGTKAKQL LQQILAVDQD TKLTAADYFL2040
 2041 MEEKHFISKE KNECRKQPFQ RAVGPEEDIV QILNSWFPEE GYVGRIVLKP QQETLEEKNI2100
 2101 VHDDREVILS SEEESFFVQV HDVSPEQPRT VIKAPRVSTA QDVIQQTLCK AKYSYSILNN2160
 2161 PNPCDYVLLE EVMKDAPNKK SSTPKSSQRI LLDQECVFQA QSKWKGAGKF ILKLKEQVQA2220
 2221 SREDKRRGIS FASELKKLTK STKQTRGLTS PPQLVASESV QSKEEKPMGA LASGDTAGYQ2280
 2281 S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.52

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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