Protein Overview: MP2K1_RAT

General Information:
Name(s) found:	MP2K1_RAT [Swiss-Prot]
Description(s) found: Found 25 descriptions. SHOW ALL	Dual specificity mitogen-activated protein kinase kinase 1 OS=Rattus norvegicus GN=Map2k1 PE=1 SV=2 [Swiss-Prot]
Organism:	Rattus norvegicus
Length:	393 amino acids
Gene Ontology:
Cellular Component:	dendrite [IDA] soluble fraction [IDA] perinuclear region of cytoplasm [IDA] cell cortex [IDA] dendrite cytoplasm [IDA] cytosol [UNKNOWN][IDA] Golgi apparatus [IDA] axon part [IDA] perikaryon [IDA] plasma membrane [IDA] microtubule [IDA]
Biological Process:	cell cycle arrest [UNKNOWN][IEA] cell proliferation [IDA] negative regulation of homotypic cell-cell adhesion [IMP] negative regulation of cell proliferation [UNKNOWN][IEA] neuron projection morphogenesis [IMP] response to axon injury [IMP] protein heterooligomerization [IPI] regulation of vascular smooth muscle contraction [IMP] protein amino acid phosphorylation [UNKNOWN][IDA][TAS] positive regulation of RNA elongation from RNA polymerase II promoter [IMP] MAPKKK cascade [IMP] activation of MAPK activity [UNKNOWN][IDA] response to oxidative stress [IDA] vesicle transport along microtubule [IDA] response to glucocorticoid stimulus [IDA] positive regulation of Ras GTPase activity [IMP] melanosome transport [IDA] placenta blood vessel development [UNKNOWN][IEA] small GTPase mediated signal transduction [UNKNOWN] neuron differentiation [UNKNOWN][IMP] mitosis [IDA] intracellular protein kinase cascade [TAS] Ras protein signal transduction [UNKNOWN] positive regulation of cell differentiation [UNKNOWN][IEA] labyrinthine layer development [UNKNOWN][IEA] cell motility [UNKNOWN][IEA] keratinocyte differentiation [UNKNOWN][IEA] Golgi inheritance [IMP] senescence [UNKNOWN][IEA] positive regulation of cell migration [IMP]
Molecular Function:	nucleotide binding [IEA] ATP binding [IDA] protein kinase binding [IPI] protein tyrosine kinase activity [IEA] protein binding [UNKNOWN][IDA][IPI] receptor signaling protein tyrosine phosphatase activity [UNKNOWN][IEA] MAP kinase kinase activity [UNKNOWN][IDA][IMP][TAS] protein serine/threonine kinase activity [UNKNOWN][IEA] transferase activity [IEA] mitogen-activated protein kinase kinase kinase binding [IDA][IPI] Ras GTPase binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV  60
   61 GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE 120
  121 CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 180
  181 REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 240
  241 SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELLFGCQVE GDAAETPPRP RTPGRPLSSY 300
  301 GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF 360
  361 IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA ASI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: MP2K1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: