Protein Overview: IL5_RAT

General Information:
Name(s) found:	IL5_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|585311\|sp\|Q08125.1\|IL5_RAT RecName: Full=Interleukin-5; Short=IL-5; AltName: Full=T-cell replacing factor; Short=TRF; AltName: Full=B-cell growth factor II; Short=BCGF-II; AltName: Full=Eosinophil differentiation factor; AltName: Full=Cytotoxic T-lymph [NCBI NR] pir\|\|A48418 interleukin-5 precursor - rat [NCBI NR] gi\|149052579\|gb\|EDM04396.1\| interleukin 5 [Rattus norvegicus] [NCBI NR] Interleukin-5 OS=Rattus norvegicus GN=Il5 PE=3 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):10-37668486 Interleukin-5 precursor [hmr_yeast5_DM3-1_pombe.fasta] interleukin 5 [Rattus rattus]gi\|585311\|sp\|Q08125\|IL5_RAT Interleukin-5 precursor (IL-5) (T-cell replacing factor) (TRF) (B-cell growth factor II) (BCGF-II) (Eosinophil differentiation factor) (Cytotoxic T lymphocyte inducer)gi\|477218\|pir\|\|A48418 interle [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Interleukin-5 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Interleukin-5 precursor (IL-5) (T-cell replacing factor) (TRF) (B-cell growth factor II) (BCGF-II) (Eosinophil differentiation factor) (Cytotoxic T-lymphocyte inducer) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] interleukin 5 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 INTERLEUKIN-5 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Il5 Interleukin-5 [rat-ipi-250309-contam.fasta] Interleukin-5 OS=Rattus norvegicus GN=Il5 [011711_HMR.fasta] Interleukin-5 OS=Rattus norvegicus GN=Il5 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	132 amino acids
Gene Ontology:
Cellular Component:	extracellular space [UNKNOWN][IEA] soluble fraction [IDA] extracellular region [IEA]
Biological Process:	inflammatory response [IEP] immune response [IEA] positive regulation of gene-specific transcription [IEA] cytokine-mediated signaling pathway [IDA][IMP] positive regulation of cell proliferation [IDA] positive regulation of B cell proliferation [IDA] positive regulation of transcription factor activity [IEA] positive regulation of eosinophil differentiation [IDA] positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN][IEA] positive regulation of JAK-STAT cascade [IMP]
Molecular Function:	growth factor activity [IEA] protein binding [UNKNOWN] cytokine activity [UNKNOWN][IDA][IMP] interleukin-5 receptor binding [IDA][IMP]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MRMLLCLNVL TLSCVWAIAM EIPMSTVVKE TLIQLSTHRA LLTSNETMRL PVPTHKNHQL 60 61 CIGEIFQGLD ILKNQTVRGG TVEILFQNLS LIKKYIDGQK EKCGEERRKT RHFLDYLQEF 120 121 LGVMSTEWAM EV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

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No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..132]	PSI-BLAST	51.39794	Interleukin-5

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
cytokine receptor binding	6.47223189691244	bayes_pls_golite062009
receptor binding	5.3304255990112	bayes_pls_golite062009
cytokine activity	5.1883241815362	bayes_pls_golite062009
growth factor activity	4.92105782010612	bayes_pls_golite062009
protein binding	3.52041127390038	bayes_pls_golite062009
binding	2.74412602806415	bayes_pls_golite062009
prolactin receptor binding	2.45721634350294	bayes_pls_golite062009
interleukin-6 receptor binding	2.37535614986843	bayes_pls_golite062009
hormone activity	2.25587306265428	bayes_pls_golite062009
interleukin-10 receptor binding	2.21581243177298	bayes_pls_golite062009
interleukin-12 binding	1.970502825442	bayes_pls_golite062009
growth hormone activity	1.68812520178671	bayes_pls_golite062009
interleukin-27 binding	1.65090888783496	bayes_pls_golite062009
ciliary neurotrophic factor receptor binding	1.59946630359187	bayes_pls_golite062009
interleukin-2 receptor binding	1.04202431319586	bayes_pls_golite062009
transcription regulator activity	0.997277159889548	bayes_pls_golite062009
interleukin-12 beta subunit binding	0.905609556134391	bayes_pls_golite062009
macrophage colony stimulating factor receptor binding	0.677853475084802	bayes_pls_golite062009
erythropoietin receptor binding	0.5867301437183	bayes_pls_golite062009
granulocyte colony-stimulating factor receptor binding	0.325361365455201	bayes_pls_golite062009
catalytic activity	0.246169290135575	bayes_pls_golite062009
interleukin-12 receptor binding	0.218984052557791	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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