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Protein Overview: IL5_RAT

General Information:
Name(s) found: IL5_RAT [Swiss-Prot]
Description(s) found:
Found 13 descriptions.
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  • Interleukin-5 OS=Rattus norvegicus GN=Il5 PE=3 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 132 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][IEA]
    soluble fraction [IDA]
    extracellular region [IEA]
    Biological Process: inflammatory response [IEP]
    immune response [IEA]
    positive regulation of gene-specific transcription [IEA]
    cytokine-mediated signaling pathway [IDA][IMP]
    positive regulation of cell proliferation [IDA]
    positive regulation of B cell proliferation [IDA]
    positive regulation of transcription factor activity [IEA]
    positive regulation of eosinophil differentiation [IDA]
    positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN][IEA]
    positive regulation of JAK-STAT cascade [IMP]
    Molecular Function: growth factor activity [IEA]
    protein binding [UNKNOWN]
    cytokine activity [UNKNOWN][IDA][IMP]
    interleukin-5 receptor binding [IDA][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRMLLCLNVL TLSCVWAIAM EIPMSTVVKE TLIQLSTHRA LLTSNETMRL PVPTHKNHQL  60
   61 CIGEIFQGLD ILKNQTVRGG TVEILFQNLS LIKKYIDGQK EKCGEERRKT RHFLDYLQEF 120
  121 LGVMSTEWAM EV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..132] PSI-BLAST 51.39794 Interleukin-5

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytokine receptor binding
    		•  6.47223189691244 bayes_pls_golite062009
  • receptor binding
    		•  5.3304255990112 bayes_pls_golite062009
  • cytokine activity
    		•  5.1883241815362 bayes_pls_golite062009
  • growth factor activity
    		•  4.92105782010612 bayes_pls_golite062009
  • protein binding
    		•  3.52041127390038 bayes_pls_golite062009
  • binding
    		•  2.74412602806415 bayes_pls_golite062009
  • prolactin receptor binding
    		•  2.45721634350294 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  2.37535614986843 bayes_pls_golite062009
  • hormone activity
    		•  2.25587306265428 bayes_pls_golite062009
  • interleukin-10 receptor binding
    		•  2.21581243177298 bayes_pls_golite062009
  • interleukin-12 binding
    		•  1.970502825442 bayes_pls_golite062009
  • growth hormone activity
    		•  1.68812520178671 bayes_pls_golite062009
  • interleukin-27 binding
    		•  1.65090888783496 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  1.59946630359187 bayes_pls_golite062009
  • interleukin-2 receptor binding
    		•  1.04202431319586 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.997277159889548 bayes_pls_golite062009
  • interleukin-12 beta subunit binding
    		•  0.905609556134391 bayes_pls_golite062009
  • macrophage colony stimulating factor receptor binding
    		•  0.677853475084802 bayes_pls_golite062009
  • erythropoietin receptor binding
    		•  0.5867301437183 bayes_pls_golite062009
  • granulocyte colony-stimulating factor receptor binding
    		•  0.325361365455201 bayes_pls_golite062009
  • catalytic activity
    		•  0.246169290135575 bayes_pls_golite062009
  • interleukin-12 receptor binding
    		•  0.218984052557791 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle