Protein Overview: NOX4_RAT

General Information:
Name(s) found:	NOX4_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|16758288\|ref\|NP_445976.1\| NADPH oxidase 4 [Rattus norvegicus] [NCBI NR] gi\|149069044\|gb\|EDM18596.1\| NADPH oxidase 4, isoform CRA_b [Rattus norvegicus] [NCBI NR] gi\|13236842\|gb\|AAK14799.1\| NADPH oxidase 4 [Rattus norvegicus] [NCBI NR] gi\|108884833\|sp\|Q924V1.2\|NOX4_RAT RecName: Full=NADPH oxidase 4; AltName: Full=Kidney superoxide-producing NADPH oxidase; AltName: Full=Kox-1 [NCBI NR] NADPH oxidase 4 OS=Rattus norvegicus GN=Nox4 PE=1 SV=2 [Swiss-Prot] Ensembl_locations(Chr-bp):1-139765118 NADPH oxidase 4 [hmr_yeast5_DM3-1_pombe.fasta] NADPH oxidase 4 [HMR_022704-rand.fasta] NADPH oxidase 4 [Rattus norvegicus]gi\|13236842\|gb\|AAK14799.1\| NADPH oxidase 4 [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] (NM_053524) NADPH oxidase 4 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] NADPH oxidase 4 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] NADPH oxidase 4 (Kidney superoxide-producing NADPH oxidase) (Kox-1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] NADPH oxidase 4, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Nox4 NADPH oxidase 4 [rat-ipi-250309-contam.fasta] NADPH oxidase 4 OS=Rattus norvegicus GN=Nox4 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	578 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum membrane [IEA] focal adhesion [IDA][IEA] NADPH oxidase complex [IDA] stress fiber [IDA] mitochondrion [IDA] membrane [IEA] integral to membrane [IEA] cell junction [IEA] endoplasmic reticulum [IEA] plasma membrane [IEA] apical plasma membrane [IDA]
Biological Process:	positive regulation of oxygen and reactive oxygen species metabolic process [IMP] cardiac cell differentiation [UNKNOWN] cell morphogenesis [ISS] negative regulation of cell proliferation [ISS] aging [IEP] superoxide anion generation [ISS] cell aging [ISS] cellular response to transforming growth factor beta stimulus [IEP] oxygen and reactive oxygen species metabolic process [UNKNOWN][ISS] cellular response to gamma radiation [IEP] response to hypoxia [IEP] superoxide metabolic process [IDA][IMP] bone resorption [UNKNOWN] positive regulation of stress fiber assembly [IMP] positive regulation of apoptosis [IMP] cellular response to cAMP [IEP] oxidation reduction [UNKNOWN][IEA][ISS] positive regulation of smooth muscle cell migration [IMP]
Molecular Function:	oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor [IDA] protein binding [IPI] iron ion binding [IEA] oxidoreductase activity [IEA] FAD binding [IEA] electron carrier activity [IEA] NAD(P)H oxidase activity [IDA] superoxide-generating NADPH oxidase activity [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALSWRSWLA NEGVKHLCLL VWLSLNVLLF WKTFLLYNQG PEYYYIHQML GLGLCLSRAS  60
   61 ASVLNLNCSL ILLPMCRTVL AYLRGSQKVP SRRTRRLLDK SKTLHITCGI TICIFSGVHV 120
  121 AAHLVNALNF SVNYSEHFLA LNAARYQNED PRKLLFTTVP GLTGVCMVVV LFLMVTASTY 180
  181 AIRVSNYDIF WYTHNLFFVF YMLLLLHVSG GLLKYQTNLD THPPGCISLN RTPSQNMSIA 240
  241 DYVSEHFHGS LPGGFSKLED HYQKTLVKIC LEEPKFQAHF PQTWIWISGP LCLYCAERLY 300
  301 RCIRSNKPVT IISVINHPSD VMELRMIKEN FKARPGQYII LHCPSVSALE NHPFTLTMCP 360
  361 TETKATFGVH FKVVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES 420
  421 LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFQ WFADLLYVLH 480
  481 NKFWQENRPD FVNIQLYLSQ TDGIQKIIGE KYHTLNSRLF IGRPRWKLLF DEIAKCNRGK 540
  541 TVGVFCCGPS SISKTLHNLS NRNNSYGTKF EYNKESFS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: NOX4_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: