Protein Overview: PTN11_RAT

General Information:
Name(s) found:	PTN11_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|84028250\|sp\|P41499.4\|PTN11_RAT RecName: Full=Tyrosine-protein phosphatase non-receptor type 11; AltName: Full=Protein-tyrosine phosphatase SYP; AltName: Full=PTP-1D; AltName: Full=SH-PTP2; Short=SHP-2; Short=Shp2 [NCBI NR] Tyrosine-protein phosphatase non-receptor type 11 OS=Rattus norvegicus GN=Ptpn11 PE=1 SV=4 [Swiss-Prot] Ensembl_locations(Chr-bp):12-37593673 [hmr_yeast5_DM3-1_pombe.fasta] Tax_Id=10116 Splice Isoform 1 of Tyrosine-protein phosphatase non-receptor type 11 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tyrosine-protein phosphatase non-receptor type 11 (Protein-tyrosine phosphatase SYP) (PTP-1D) (SH-PTP2) (SHP-2) (Shp2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Ptpn11 Isoform 1 of Tyrosine-protein phosphatase non-receptor type 11 [rat-ipi-250309-contam.fasta] Isoform 1 of Tyrosine-protein phosphatase non-receptor type 11 OS=Rattus norvegicus GN=Ptpn11 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	597 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [IDA] cytoplasm [IEA] mitochondrion [IDA] cytosol [UNKNOWN][IDA] protein complex [IDA]
Biological Process:	organ growth [UNKNOWN][IEA] regulation of multicellular organism growth [UNKNOWN][IEA] reproductive process in a multicellular organism [UNKNOWN][IEA] protein amino acid dephosphorylation [IDA] triglyceride metabolic process [UNKNOWN][IEA] positive regulation of hormone secretion [UNKNOWN][IEA] negative regulation of insulin secretion [UNKNOWN][IEA] positive regulation of signal transduction [UNKNOWN][IEA] negative regulation of growth hormone secretion [UNKNOWN][IEA] hormone metabolic process [UNKNOWN][IEA] regulation of protein export from nucleus [UNKNOWN][IEA] negative regulation of hormone secretion [UNKNOWN] hormone-mediated signaling pathway [UNKNOWN][IEA] DNA damage checkpoint [UNKNOWN][IEA] activation of MAPK activity [UNKNOWN][IEA] nerve growth factor receptor signaling pathway [UNKNOWN][IEA] negative regulation of cortisol secretion [UNKNOWN][IEA] axonogenesis [UNKNOWN][IEA] lipid metabolic process [UNKNOWN][IEA] glucose homeostasis [UNKNOWN][IEA]
Molecular Function:	phosphoprotein phosphatase activity [UNKNOWN] protein domain specific binding [IPI] protein binding [UNKNOWN][IPI] non-membrane spanning protein tyrosine phosphatase activity [UNKNOWN] protein tyrosine phosphatase activity [IDA] phospholipase binding [IDA] insulin receptor substrate binding [IPI] peptide hormone receptor binding [UNKNOWN][IEA] insulin receptor binding [IDA] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG  60
   61 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK 120
  121 EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDSKSKVTHV MIRCQELKYD 180
  181 VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 240
  241 DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300
  301 VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 360
  361 ERGKSKCVKY WPDECALKEY GVMRVRNVRE SAAHDYTLRE LKLSKVGQAL LQGNTERTVW 420
  421 QYHFRTWPDH GVPSDPGGVL DFLEEVHHKQ ESIVDAGPVV VHCSAGIGRT GTFIVIDILI 480
  481 DIIREKGVDC DIDVPKTIQM VRSQRSGMVQ TEAQYRFIYM AVQHYIETLQ RRIEEEQKSK 540
  541 RKGHEYTNIK YSLVDQTSGD QSPLPPCTPT PPCAEMREDS ARVYENVGLM QQQRSFR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: PTN11_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: