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Protein Overview: PP2AB_RAT

General Information:
Name(s) found: PP2AB_RAT [Swiss-Prot]
Description(s) found:
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  • gi|8394021|ref|NP_058736.1| protein phosphatase 2a, catalytic subunit, beta isoform [Rattus norvegicus] [NCBI NR]
  • pir||PART2B phosphoprotein phosphatase (EC 3.1.3.16) 2A-beta catalytic chain - rat [NCBI NR]
  • gi|56896|emb|CAA32249.1| unnamed protein product [Rattus norvegicus] [NCBI NR]
  • gi|55250772|gb|AAH85926.1| Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [Rattus norvegicus] [NCBI NR]
  • gi|50402232|sp|P62716.1|PP2AB_RAT RecName: Full=Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; Short=PP2A-beta [NCBI NR]
  • gi|206303|gb|AAA41912.1| protein phosphatase 2A-beta catalytic subunit [NCBI NR]
  • Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Rattus norvegicus GN=Ppp2cb PE=2 SV=1 [Swiss-Prot]
  • (P62716) Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform (EC 3.1.3.16) (PP2A-beta) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):16-58434156;16-58434156 Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform [hmr_yeast5_DM3-1_pombe.fasta]
  • protein phosphatase 2a, catalytic subunit, beta isoform; Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; Protein phosphatase 2 (formerly 2A) catalytic subunit beta isoform [HMR_022704-rand.fasta]
  • Protein phosphatase 2a, catalytic subunit, beta isoform [Rattus norvegicus]gi|8394021|ref|NP_058736.1| protein phosphatase 2a, catalytic subunit, beta isoform [Rattus norvegicus]gi|4758952|ref|NP_004147.1| protein phosphatase 2 (formerly 2A), catalytic [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 Serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • (NM_017040) protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • protein phosphatase 2a, catalytic subunit, beta isoform [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • protein phosphatase 2A-beta catalytic subunit [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SERINE/THREONINE PROTEIN PHOSPHATASE 2A, CATALYTIC SUBUNIT, BETA ISOFORM [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Ppp2cb Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [rat-ipi-250309-contam.fasta]
  • Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Rattus norvegicus GN=Ppp2cb [011711_HMR.fasta]
  • Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Rattus norvegicus GN=Ppp2cb PE=1 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 309 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    cytoskeleton [IEA]
    cytoplasm [UNKNOWN][IEA]
    spindle pole [IEA]
    protein phosphatase type 2A complex [UNKNOWN][IEA]
    chromosome, centromeric region [IEA]
    Biological Process: proteasomal ubiquitin-dependent protein catabolic process [UNKNOWN][IEA]
    negative regulation of Ras protein signal transduction [IDA]
    negative regulation of apoptosis [UNKNOWN][IEA]
    protein amino acid dephosphorylation [IDA]
    regulation of gene expression [UNKNOWN][IEA]
    response to antibiotic [UNKNOWN][IEA]
    response to chemical stimulus [UNKNOWN]
    response to hydrogen peroxide [UNKNOWN][IEA]
    Molecular Function: protein serine/threonine phosphatase activity [IDA]
    protein domain specific binding [IPI]
    protein binding [UNKNOWN]
    protein C-terminus binding [IPI]
    metal ion binding [IEA]
    protein heterodimerization activity [ISS]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG  60
   61 QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES 120
  121 RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180
  181 RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240
  241 HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300
  301 TRRTPDYFL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..309] PSI-BLAST 108.0 No description for 2ie4C was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.126411744957937 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle