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Protein Overview: HMCS1_RAT

General Information:
Name(s) found: HMCS1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|8393538|ref|NP_058964.1| hydroxymethylglutaryl-CoA synthase 1 [Rattus norvegicus] [NCBI NR]
  • gi|62642888|ref|XP_579405.1| PREDICTED: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [Rattus norvegicus] [NCBI NR]
  • gi|55947|emb|CAA36852.1| cytosolic 3-hydroxy 3-methylglutaryl coenzyme A synthase [Rattus norvegicus] [NCBI NR]
  • gi|149059419|gb|EDM10426.1| rCG44679, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149059418|gb|EDM10425.1| rCG44679, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|123333|sp|P17425.1|HMCS1_RAT RecName: Full=Hydroxymethylglutaryl-CoA synthase, cytoplasmic; Short=HMG-CoA synthase; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase [NCBI NR]
  • pir||S12736 hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5), cytosolic - rat [NCBI NR]
  • (P17425) Hydroxymethylglutaryl-CoA synthase, cytoplasmic (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase) [Swiss-Prot]
  • Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Rattus norvegicus GN=Hmgcs1 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):2-122030905 Hydroxymethylglutaryl-CoA synthase, cytoplasmic [hmr_yeast5_DM3-1_pombe.fasta]
  • 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [HMR_022704-rand.fasta]
  • 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [Rattus norvegicus]gi|55947|emb|CAA36852.1| cytosolic 3-hydroxy 3-methylglutaryl coenzyme A synthase [Rattus norvegicus]gi|123333|sp|P17425|HMCS_RAT Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-Co [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Hydroxymethylglutaryl-CoA synthase, cytoplasmic [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_017268) 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • rCG44679, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • cytosolic 3-hydroxy 3-methylglutaryl coenzyme A synthase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • hydroxymethylglutaryl-CoA synthase 1 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Hmgcs1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic [rat-ipi-250309-contam.fasta]
  • Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Rattus norvegicus GN=Hmgcs1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 520 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    cytosol [UNKNOWN][IDA][TAS]
    Biological Process: response to drug [IEP]
    metabolic process [IEA]
    cholesterol biosynthetic process [IEA]
    isoprenoid biosynthetic process [IEA]
    response to organic nitrogen [IDA]
    Molecular Function: protein homodimerization activity [IDA]
    drug binding [IDA]
    hydroxymethylglutaryl-CoA synthase activity [UNKNOWN][IMP][TAS]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGSLPLNAE ACWPKDVGIV ALEIYFPSQY VDQAELEKYD GVDAGKYTIG LGQARMGFCT  60
   61 DREDINSLCL TVVQKLMERN SLSYDCIGRL EVGTETIIDK SKSVKSNLMQ LFEESGNTDI 120
  121 EGIDTTNACY GGTAAVFNAV NWIESSSWDG RYALVVAGDI AIYASGNARP TGGVGAVALL 180
  181 IGPNAPVIFD RGLRGTHMQH AYDFYKPDML SEYPVVDGKL SIQCYLSALD RCYSVYRKKI 240
  241 RAQWQKEGKD KDFTLNDFGF MIFHSPYCKL VQKSLARMFL NDFLNDQNRD KNSIYSGLEA 300
  301 FGDVKLEDTY FDRDVEKAFM KASAELFNQK TKASLLVSNQ NGNMYTSSVY GSLASVLAQY 360
  361 SPQQLAGKRI GVFSYGSGLA ATLYSLKVTQ DATPGSALDK ITASLCDLKS RLDSRTCVAP 420
  421 DVFAENMKLR EDTHHLANYI PQCSIDSLFE GTWYLVRVDE KHRRTYARRP STNDHSLDEG 480
  481 VGLVHSNTAT EHIPSPAKKV PRLPATSGEP ESAVISNGEH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle