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Protein Overview: TNFB_MOUSE

General Information:
Name(s) found: TNFB_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|91052|pir||B27303 tumor necrosis factor beta precursor - mouse [NCBI NR]
  • gi|74148916|dbj|BAE32147.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|7106343|ref|NP_034865.1| lymphotoxin A [Mus musculus] [NCBI NR]
  • gi|68534905|gb|AAH99464.1| Lta protein [Mus musculus] [NCBI NR]
  • gi|54843|emb|CAA68330.1| lymphotoxin [Mus musculus] [NCBI NR]
  • gi|54831|emb|CAA68529.1| TNF-beta [Mus musculus] [NCBI NR]
  • gi|495467|gb|AAA18593.1| lymphotoxin-alpha [NCBI NR]
  • gi|3941742|gb|AAC82485.1| LTA [Mus musculus] [NCBI NR]
  • gi|26348469|dbj|BAC37874.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|202089|gb|AAA40460.1| lymphotoxin precursor [NCBI NR]
  • gi|135941|sp|P09225.1|TNFB_MOUSE RecName: Full=Lymphotoxin-alpha; Short=LT-alpha; AltName: Full=TNF-beta; AltName: Full=Tumor necrosis factor ligand superfamily member 1; Flags: Precursor [NCBI NR]
  • Lymphotoxin-alpha OS=Mus musculus GN=Lta PE=2 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):17-33819684 Lymphotoxin-alpha precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • lymphotoxin A; lymphotoxin alpha; TNF beta [HMR_022704-rand.fasta]
  • Lymphotoxin-alpha precursor [ipi.MOUSE.v3.06.fasta]
  • lymphotoxin A [Mus musculus]gi|3941742|gb|AAC82485.1| LTA [Mus musculus]gi|135941|sp|P09225|TNFB_MOUSE Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1)gi|91052|pir||B27303 tumor necrosis factor beta [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 Lymphotoxin-alpha precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_010735) lymphotoxin A; lymphotoxin alpha; TNF beta; lymphotoxin [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • lymphotoxin A [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • lymphotoxin [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • TNF-beta [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Lta protein [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • LTA [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • lymphotoxin precursor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • lymphotoxin-alpha [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 LYMPHOTOXIN-ALPHA PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Lta Lymphotoxin-alpha [mouse-ipi-250309-contam.fasta]
  • lymphotoxin A precursor [Mus musculus] [NCBI-RefSeq_mouse_na_09-14-2009_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Lta Lymphotoxin-alpha precursor [ipi.MOUSE_jw_12may08.contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Lta Lymphotoxin-alpha precursor ENSMUSG00000024402 IPI00134681 IPI00653314 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • lymphotoxin-alpha precursor [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00134681.1|SWISS-PROT:P09225|TREMBL:Q542S2|ENSEMBL:ENSMUSP00000025266|REFSEQ:NP_034865 Tax_Id=10090 Gene_Symbol=Lta Lymphotoxin-alpha [ipi.MOUSE.fasta.20090209]
  • Lymphotoxin-alpha OS=Mus musculus GN=Lta [011711_HMR.fasta]
  • sp|P09225|TNFB_MOUSE Lymphotoxin-alpha OS=Mus musculus GN=Lta PE=2 SV=1 [uniprot.sptr.mouse.20130102]
  • tr|Q542S2|Q542S2_MOUSE Lta protein OS=Mus musculus GN=Lta PE=2 SV=1 [uniprot.sptr.mouse.20130102]
  • Lta protein OS=Mus musculus GN=Lta PE=2 SV=1 [mouse-uniprot-290313-contam.fasta]
  • Isoform of P09225, Lta protein OS=Mus musculus GN=Lta PE=2 SV=1 [MOUSE.fasta.20160308]
    • Organism: Mus musculus
    Length: 202 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [IEA]
    membrane [IEA]
    extracellular region [IEA]
    Biological Process: cell proliferation [TAS]
    positive regulation of cell proliferation [TAS]
    lymph node development [IMP]
    cellular process [TAS]
    inflammatory response [TAS]
    positive regulation of chronic inflammatory response to antigenic stimulus [IGI]
    immune response [IEA]
    transformed cell apoptosis [TAS]
    negative regulation of growth of symbiont in host [IGI]
    negative regulation of fibroblast proliferation [UNKNOWN]
    positive regulation of interferon-gamma production [IGI]
    positive regulation of apoptosis [UNKNOWN]
    humoral immune response [IMP]
    positive regulation of humoral immune response mediated by circulating immunoglobulin [IGI]
    defense response to Gram-positive bacterium [IGI]
    Molecular Function: tumor necrosis factor receptor binding [TAS]
    cytokine activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLLGRLHLL RVLGTPPVFL LGLLLALPLG AQGLSGVRFS AARTAHPLPQ KHLTHGILKP  60
   61 AAHLVGYPSK QNSLLWRAST DRAFLRHGFS LSNNSLLIPT SGLYFVYSQV VFSGESCSPR 120
  121 AIPTPIYLAH EVQLFSSQYP FHVPLLSAQK SVYPGLQGPW VRSMYQGAVF LLSKGDQLST 180
  181 HTDGISHLHF SPSSVFFGAF AL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] MSA 3.092996 View MSA. No confident structure predictions are available.
    2 View Details [70..202] PSI-BLAST 44.39794 Tumor necrosis factor (TNF)


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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