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Protein Overview: TNFB_MOUSE

General Information:
Name(s) found: TNFB_MOUSE [Swiss-Prot]
Description(s) found:
Found 39 descriptions.
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  • Lymphotoxin-alpha OS=Mus musculus GN=Lta PE=2 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 202 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [IEA]
    membrane [IEA]
    extracellular region [IEA]
    Biological Process: cell proliferation [TAS]
    positive regulation of cell proliferation [TAS]
    lymph node development [IMP]
    cellular process [TAS]
    inflammatory response [TAS]
    positive regulation of chronic inflammatory response to antigenic stimulus [IGI]
    immune response [IEA]
    transformed cell apoptosis [TAS]
    negative regulation of growth of symbiont in host [IGI]
    negative regulation of fibroblast proliferation [UNKNOWN]
    positive regulation of interferon-gamma production [IGI]
    positive regulation of apoptosis [UNKNOWN]
    humoral immune response [IMP]
    positive regulation of humoral immune response mediated by circulating immunoglobulin [IGI]
    defense response to Gram-positive bacterium [IGI]
    Molecular Function: tumor necrosis factor receptor binding [TAS]
    cytokine activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLLGRLHLL RVLGTPPVFL LGLLLALPLG AQGLSGVRFS AARTAHPLPQ KHLTHGILKP  60
   61 AAHLVGYPSK QNSLLWRAST DRAFLRHGFS LSNNSLLIPT SGLYFVYSQV VFSGESCSPR 120
  121 AIPTPIYLAH EVQLFSSQYP FHVPLLSAQK SVYPGLQGPW VRSMYQGAVF LLSKGDQLST 180
  181 HTDGISHLHF SPSSVFFGAF AL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] MSA 3.092996 View MSA. No confident structure predictions are available.
    2 View Details [70..202] PSI-BLAST 44.39794 Tumor necrosis factor (TNF)


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle