Protein Overview: SOCS1_MOUSE

General Information:
Name(s) found:	SOCS1_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|74185805\|dbj\|BAE32775.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|6753424\|ref\|NP_034026.1\| suppressor of cytokine signaling 1 [Mus musculus] [NCBI NR] gi\|5825620\|gb\|AAD53324.1\|AF180302_1 suppressor of cytokine signalling-1 [Mus musculus] [NCBI NR] gi\|4581881\|gb\|AAD24777.1\| suppressor of cytokine signalling-1; Socs-1 [Mus musculus] [NCBI NR] gi\|26324572\|dbj\|BAC26040.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|2245382\|gb\|AAB62400.1\| suppressor of cytokine signalling-1 [Mus musculus] [NCBI NR] gi\|20178098\|sp\|O35716.1\|SOCS1_MOUSE RecName: Full=Suppressor of cytokine signaling 1; Short=SOCS-1; AltName: Full=JAK-binding protein; Short=JAB; AltName: Full=STAT-induced STAT inhibitor 1; Short=SSI-1 [NCBI NR] gi\|148664907\|gb\|EDK97323.1\| suppressor of cytokine signaling 1 [Mus musculus] [NCBI NR] gi\|124376396\|gb\|AAI32367.1\| Suppressor of cytokine signaling 1 [Mus musculus] [NCBI NR] gi\|124376044\|gb\|AAI32369.1\| Suppressor of cytokine signaling 1 [Mus musculus] [NCBI NR] Suppressor of cytokine signaling 1 OS=Mus musculus GN=Socs1 PE=1 SV=1 [Swiss-Prot] (O35716) Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT induced STAT inhibitor 1) (SSI-1) [Swiss-Prot] Ensembl_locations(Chr-bp):16-10267305 Suppressor of cytokine signaling 1 [hmr_yeast5_DM3-1_pombe.fasta] suppressor of cytokine signaling 1; cytokine inducible SH2-containing protein 7; cytokine inducible SH2-containing protein 1; JAK-binding protein; JAK2-binding protein; STAT-induced STAT inhibitor 1 [HMR_022704-rand.fasta] Suppressor of cytokine signaling 1 [ipi.MOUSE.v3.06.fasta] suppressor of cytokine signaling 1 [Mus musculus]gi\|4581881\|gb\|AAD24777.1\| suppressor of cytokine signalling-1; Socs-1 [Mus musculus]gi\|2245382\|gb\|AAB62400.1\| suppressor of cytokine signalling-1 [Mus musculus]gi\|20178098\|sp\|O35716\|SOC1_MOUSE Suppressor [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Suppressor of cytokine signaling 1 [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_009896) cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; JAK-binding protein; JAK2-binding protein; STAT-induced STAT inhibitor 1; suppressor of cytokine signaling 1 [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] suppressor of cytokine signaling 1 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Suppressor of cytokine signaling 1 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] suppressor of cytokine signalling-1 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] suppressor of cytokine signalling-1; Socs-1 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 SUPPRESSOR OF CYTOKINE SIGNALING 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Socs1 Suppressor of cytokine signaling 1 [mouse-ipi-250309-contam.fasta] Tax_Id=10090 Gene_Symbol=Socs1 Suppressor of cytokine signaling 1 ENSMUSG00000038037 IPI00133836 [IPIxENS.MOUSE_plus_REVERSE.fasta] IPI:IPI00133836.1\|SWISS-PROT:O35716\|TREMBL:A2RT46\|ENSEMBL:ENSMUSP00000038121\|REFSEQ:NP_034026 Tax_Id=10090 Gene_Symbol=Socs1 Suppressor of cytokine signaling 1 [ipi.MOUSE.fasta.20090209] Suppressor of cytokine signaling 1 OS=Mus musculus GN=Socs1 [011711_HMR.fasta] sp\|O35716\|SOCS1_MOUSE Suppressor of cytokine signaling 1 OS=Mus musculus GN=Socs1 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	212 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	negative regulation of signal transduction [IEA] intracellular signaling pathway [IEA] negative regulation of tyrosine phosphorylation of Stat3 protein [IDA] regulation of protein amino acid phosphorylation [IDA] cytokine-mediated signaling pathway [IDA][IMP] fat cell differentiation [IMP] regulation of growth [IEA] negative regulation of insulin receptor signaling pathway [IDA] negative regulation of JAK-STAT cascade [IMP] JAK-STAT cascade [IDA]
Molecular Function:	protein binding [IPI] kinase inhibitor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVARNQVAAD NAISPAAEPR RRSEPSSSSS SSSPAAPVRP RPCPAVPAPA PGDTHFRTFR  60
   61 SHSDYRRITR TSALLDACGF YWGPLSVHGA HERLRAEPVG TFLVRDSRQR NCFFALSVKM 120
  121 ASGPTSIRVH FQAGRFHLDG SRETFDCLFE LLEHYVAAPR RMLGAPLRQR RVRPLQELCR 180
  181 QRIVAAVGRE NLARIPLNPV LRDYLSSFPF QI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..212]	PSI-BLAST	26.69897	CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Protein Overview: SOCS1_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: