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View Structure Prediction Details

Protein: SOCS1_MOUSE
Organism: Mus musculus
Length: 212 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SOCS1_MOUSE.

Description E-value Query
Range
Subject
Range
gi|157831104, gi... - gi|5822499|pdb|2SRC| Chain , Crystal Structure Of Human Tyrosine-Protein Kinase C-Src, In Complex ...
164.0 [0..55] [202..42]
gi|223627 - gi|223627|prf||0903255A protein v-src
164.0 [0..55] [202..369]
gi|2780916, gi|1... - gi|2780916|pdb|2PTK| Chain , Chicken Src Tyrosine Kinase, gi|157835762|pdb|2PTK|A Chain A, Chicken...
163.0 [0..55] [202..43]
gi|89268164 - gi|89268164|emb|CAJ81699.1| Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 [Xenopus tropicalis]
163.0 [0..53] [202..125]
gi|71089987, gi|... - gi|71089989|gb|AAZ23849.1| tyrosine protein kinase c-src [Rattus norvegicus], gi|71089987|gb|AAZ2384...
163.0 [0..55] [202..120]
gi|148233834, gi... - gi|71681264|gb|AAI00229.1| MGC115231 protein [Xenopus laevis], gi|148233834|ref|NP_001089660.1| hypo...
163.0 [0..53] [202..125]

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Predicted Domain #1
Region A:
Residues: [1-212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVARNQVAAD NAISPAAEPR RRSEPSSSSS SSSPAAPVRP RPCPAVPAPA PGDTHFRTFR  60
   61 SHSDYRRITR TSALLDACGF YWGPLSVHGA HERLRAEPVG TFLVRDSRQR NCFFALSVKM 120
  121 ASGPTSIRVH FQAGRFHLDG SRETFDCLFE LLEHYVAAPR RMLGAPLRQR RVRPLQELCR 180
  181 QRIVAAVGRE NLARIPLNPV LRDYLSSFPF QI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 2c9wA
Description: CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.48735671726158 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
insulin receptor binding 2.1238568876176 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.39494498759145 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
kinase activity 1.31102709888086 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
protein kinase activity 1.17876498439223 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.098112861344 bayes_pls_golite062009
signal transducer activity 0.999269271132931 bayes_pls_golite062009
molecular transducer activity 0.999269271132931 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.950445630788802 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
receptor binding 0.737505966141925 bayes_pls_golite062009
nucleic acid binding 0.549336064224261 bayes_pls_golite062009
transcription regulator activity 0.489780129542396 bayes_pls_golite062009
transferase activity 0.4880159130787 bayes_pls_golite062009
DNA binding 0.32481747214536 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 0.151092725944757 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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