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Protein Overview: SOCS1_MOUSE

General Information:
Name(s) found: SOCS1_MOUSE [Swiss-Prot]
Description(s) found:
Found 30 descriptions.
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  • Suppressor of cytokine signaling 1 OS=Mus musculus GN=Socs1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 212 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: negative regulation of signal transduction [IEA]
    intracellular signaling pathway [IEA]
    negative regulation of tyrosine phosphorylation of Stat3 protein [IDA]
    regulation of protein amino acid phosphorylation [IDA]
    cytokine-mediated signaling pathway [IDA][IMP]
    fat cell differentiation [IMP]
    regulation of growth [IEA]
    negative regulation of insulin receptor signaling pathway [IDA]
    negative regulation of JAK-STAT cascade [IMP]
    JAK-STAT cascade [IDA]
    Molecular Function: protein binding [IPI]
    kinase inhibitor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVARNQVAAD NAISPAAEPR RRSEPSSSSS SSSPAAPVRP RPCPAVPAPA PGDTHFRTFR  60
   61 SHSDYRRITR TSALLDACGF YWGPLSVHGA HERLRAEPVG TFLVRDSRQR NCFFALSVKM 120
  121 ASGPTSIRVH FQAGRFHLDG SRETFDCLFE LLEHYVAAPR RMLGAPLRQR RVRPLQELCR 180
  181 QRIVAAVGRE NLARIPLNPV LRDYLSSFPF QI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..212] PSI-BLAST 26.69897 CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.48735671726158 bayes_pls_golite062009
  • protein binding
    		•  2.14586566310919 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.1238568876176 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.39494498759145 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • kinase activity
    		•  1.31102709888086 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • protein kinase activity
    		•  1.17876498439223 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.098112861344 bayes_pls_golite062009
  • signal transducer activity
    		•  0.999269271132931 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.999269271132931 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.950445630788802 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • receptor binding
    		•  0.737505966141925 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.549336064224261 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.489780129542396 bayes_pls_golite062009
  • transferase activity
    		•  0.4880159130787 bayes_pls_golite062009
  • DNA binding
    		•  0.32481747214536 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  0.151092725944757 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle