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Protein Overview: TGFR2_MOUSE

General Information:
Name(s) found: TGFR2_MOUSE [Swiss-Prot]
Description(s) found:
Found 34 descriptions.
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  • TGF-beta receptor type-2 OS=Mus musculus GN=Tgfbr2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 592 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [UNKNOWN]
    caveola [UNKNOWN]
    cytoplasm [UNKNOWN]
    membrane [IEA]
    external side of plasma membrane [IDA]
    integral to membrane [IEA]
    cytosol [UNKNOWN]
    receptor complex [IEA]
    cell surface [UNKNOWN]
    Biological Process: trachea formation [IMP]
    negative regulation of cardiac muscle cell proliferation [UNKNOWN]
    lung lobe morphogenesis [IMP]
    mammary gland morphogenesis [IMP]
    embryonic hemopoiesis [IMP]
    negative regulation of cell proliferation [UNKNOWN]
    palate development [IMP]
    transforming growth factor beta receptor signaling pathway [UNKNOWN]
    auxin biosynthetic process [IEA]
    transmembrane receptor protein serine/threonine kinase signaling pathway [IEA]
    vasculogenesis [IMP]
    protein amino acid phosphorylation [TAS]
    lung morphogenesis [IMP]
    positive regulation of B cell tolerance induction [IMP]
    positive regulation of smooth muscle cell proliferation [UNKNOWN]
    heart development [IMP]
    patterning of blood vessels [IMP]
    in utero embryonic development [IMP]
    myeloid dendritic cell differentiation [IMP]
    activation of protein kinase activity [IDA]
    lung development [IMP]
    response to cholesterol [IDA]
    common-partner SMAD protein phosphorylation [UNKNOWN]
    smoothened signaling pathway [IMP]
    embryonic cranial skeleton morphogenesis [IMP]
    trachea morphogenesis [IMP]
    positive regulation of mesenchymal cell proliferation [IMP]
    brain development [IMP]
    bronchus development [IMP]
    receptor-mediated endocytosis [UNKNOWN]
    bronchus morphogenesis [IMP]
    regulation of cell proliferation [IMP]
    positive regulation of tolerance induction to self antigen [IMP]
    organ morphogenesis [UNKNOWN]
    gastrulation [IMP]
    positive regulation of T cell tolerance induction [IMP]
    positive regulation of NK T cell differentiation [IMP]
    Molecular Function: protein kinase activity [IEA]
    protein serine/threonine kinase activity [IEA]
    receptor activity [IEA]
    transforming growth factor beta receptor activity, type II [UNKNOWN]
    nucleotide binding [IEA]
    ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [IEA]
    protein binding [IPI]
    SMAD binding [IDA]
    metal ion binding [IEA]
    mitogen-activated protein kinase kinase kinase binding [UNKNOWN]
    transferase activity [IEA]
    kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SDVEMEAQKD ASIHLSCNRT IHPLKHFNSD  60
   61 VMASDNGGAV KLPQLCKFCD VRLSTCDNQK SCMSNCSITA ICEKPHEVCV AVWRKNDKNI 120
  121 TLETVCHDPK LTYHGFTLED AASPKCVMKE KKRAGETFFM CACNMEECND YIIFSEEYTT 180
  181 SSPDLLLVII QVTGVSLLPP LGIAIAVIII FYCYRVHRQQ KLSPSWESSK PRKLMDFSDN 240
  241 CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA 300
  301 VKIFPYEEYS SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE 360
  361 YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL 420
  421 CDFGLSLRLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW 480
  481 EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDSVLRDR GRPEIPSFWL NHQGIQIVCE 540
  541 TLTECWDHDP EARLTAQCVA ERFSELEHPE RLSGRSCSQE KIPEDGSLNT TK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.12

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle