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Protein Overview: TNFL6_MOUSE

General Information:
Name(s) found: TNFL6_MOUSE [Swiss-Prot]
Description(s) found:
Found 29 descriptions.
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  • Tumor necrosis factor ligand superfamily member 6 OS=Mus musculus GN=Faslg PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 279 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [IEA]
    caveola [UNKNOWN]
    perinuclear region of cytoplasm [UNKNOWN]
    membrane [IEA]
    membrane raft [UNKNOWN]
    integral to membrane [IEA]
    external side of plasma membrane [IDA]
    cytoplasmic membrane-bounded vesicle [UNKNOWN]
    extracellular region [IEA]
    plasma membrane [IEA]
    Biological Process: signal transduction [IEA]
    positive regulation of cell proliferation [UNKNOWN]
    retinal cell programmed cell death [IMP]
    positive regulation of epidermal growth factor receptor signaling pathway [UNKNOWN]
    induction of apoptosis via death domain receptors [UNKNOWN]
    induction of apoptosis by extracellular signals [IDA]
    positive regulation of neuron apoptosis [UNKNOWN]
    immune response [IEA]
    inflammatory cell apoptosis [UNKNOWN]
    endosomal lumen acidification [UNKNOWN]
    apoptosis [IGI]
    positive regulation of apoptosis [UNKNOWN][IGI]
    cellular chloride ion homeostasis [UNKNOWN]
    Molecular Function: tumor necrosis factor receptor binding [UNKNOWN]
    cytokine activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQPMNYPCP QIFWVDSSAT SSWAPPGSVF PCPSCGPRGP DQRRPPPPPP PVSPLPPPSQ  60
   61 PLPLPPLTPL KKKDHNTNLW LPVVFFMVLV ALVGMGLGMY QLFHLQKELA ELREFTNQSL 120
  121 KVSSFEKQIA NPSTPSEKKE PRSVAHLTGN PHSRSIPLEW EDTYGTALIS GVKYKKGGLV 180
  181 INETGLYFVY SKVYFRGQSC NNQPLNHKVY MRNSKYPEDL VLMEEKRLNY CTTGQIWAHS 240
  241 SYLGAVFNLT SADHLYVNIS QLSLINFEES KTFFGLYKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] MSA 1.086973 View MSA. No confident structure predictions are available.
    2 View Details [132..279] PSI-BLAST 50.522879 Tumor necrosis factor (TNF)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • receptor binding
    		•  3.37824597039547 bayes_pls_golite062009
  • tumor necrosis factor receptor superfamily binding
    		•  3.27382150819697 bayes_pls_golite062009
  • protein binding
    		•  2.25413201891408 bayes_pls_golite062009
  • binding
    		•  1.76110862494815 bayes_pls_golite062009
  • cytokine activity
    		•  1.44696622202601 bayes_pls_golite062009
  • CD40 receptor binding
    		•  1.32291890442774 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  1.28185157337226 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  1.2326564264318 bayes_pls_golite062009
  • cell surface binding
    		•  1.12145675554147 bayes_pls_golite062009
  • tumor necrosis factor receptor binding
    		•  0.83659914028185 bayes_pls_golite062009
  • eukaryotic cell surface binding
    		•  0.3981620493951 bayes_pls_golite062009
  • hormone activity
    		•  0.0434508002092211 bayes_pls_golite062009
  • caspase inhibitor activity
    		•  0.0237319623798404 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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