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View Structure Prediction Details

Protein: TNFL6_MOUSE
Organism: Mus musculus
Length: 279 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TNFL6_MOUSE.

Description E-value Query
Range		 Subject
Range
gi|31127301 - gi|31127301|gb|AAH52866.1| Fasl protein [Mus musculus]
 331.0 [0..1] [279..1]
gi|74136237, gi|... - gi|74136237|ref|NP_001028010.1| FAS antigen CD95 [Macaca mulatta], gi|13650010|gb|AAK37539.1|AF34485...
 319.0 [0..1] [279..1]
TNFL6_MACFA - Tumor necrosis factor ligand superfamily member 6 OS=Macaca fascicularis GN=FASLG PE=2 SV=1
TNFL6_MACMU - Tumor necrosis factor ligand superfamily member 6 OS=Macaca mulatta GN=FASLG PE=2 SV=1
TNFL6_MACNE - Tumor necrosis factor ligand superfamily member 6 OS=Macaca nemestrina GN=FASLG PE=2 SV=1
 319.0 [0..1] [279..1]
TNFL6_CERAT - Tumor necrosis factor ligand superfamily member 6 OS=Cercocebus atys GN=FASLG PE=2 SV=1
 317.0 [0..1] [279..1]
gi|114565468 - gi|114565468|ref|XP_524967.2| PREDICTED: fas ligand [Pan troglodytes]
 317.0 [0..1] [279..1]
TNFL6_FELCA - Tumor necrosis factor ligand superfamily member 6 OS=Felis catus GN=FASLG PE=2 SV=1
 317.0 [0..1] [279..1]
gi|123993581, gi... - gi|61363641|gb|AAX42422.1| tumor necrosis factor superfamily member 6 [synthetic construct], gi|6136...
FASLG - Fas ligand (TNF superfamily, member 6)
 315.0 [0..1] [279..1]
gi|60830321 - gi|60830321|gb|AAX36923.1| tumor necrosis factor superfamily member 6 [synthetic construct]
 315.0 [0..1] [279..1]

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Predicted Domain #1
Region A:
Residues: [1-131] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQPMNYPCP QIFWVDSSAT SSWAPPGSVF PCPSCGPRGP DQRRPPPPPP PVSPLPPPSQ  60
   61 PLPLPPLTPL KKKDHNTNLW LPVVFFMVLV ALVGMGLGMY QLFHLQKELA ELREFTNQSL 120
  121 KVSSFEKQIA N

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [132-279] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSTPSEKKEP RSVAHLTGNP HSRSIPLEWE DTYGTALISG VKYKKGGLVI NETGLYFVYS  60
   61 KVYFRGQSCN NQPLNHKVYM RNSKYPEDLV LMEEKRLNYC TTGQIWAHSS YLGAVFNLTS 120
  121 ADHLYVNISQ LSLINFEESK TFFGLYKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.522879
Match: 1a8mA
Description: Tumor necrosis factor (TNF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.37824597039547 bayes_pls_golite062009
tumor necrosis factor receptor superfamily binding 3.27382150819697 bayes_pls_golite062009
protein binding 2.25413201891408 bayes_pls_golite062009
binding 1.76110862494815 bayes_pls_golite062009
cytokine activity 1.44696622202601 bayes_pls_golite062009
CD40 receptor binding 1.32291890442774 bayes_pls_golite062009
peptidase inhibitor activity 1.28185157337226 bayes_pls_golite062009
endopeptidase inhibitor activity 1.2326564264318 bayes_pls_golite062009
cell surface binding 1.12145675554147 bayes_pls_golite062009
tumor necrosis factor receptor binding 0.83659914028185 bayes_pls_golite062009
eukaryotic cell surface binding 0.3981620493951 bayes_pls_golite062009
hormone activity 0.0434508002092211 bayes_pls_golite062009
caspase inhibitor activity 0.0237319623798404 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle