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Protein Overview: Poxm-PC

General Information:
Name(s) found: Poxm-PC / FBpp0110325 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Pox meso is referred to in FlyBase by the symbol Dmel\Poxm (CG9610, FBgn0003129). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4143895..4159514. It has the cytological map location 84F11-84F12. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: larval somatic muscle development. 8 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: organ system; abdominal oblique muscle; embryonic/larval hypodermal muscle; abdominal transverse muscle; abdominal longitudinal muscle; acute muscle; adult; abdominal ventral oblique muscle 4; abdominal ventral oblique muscle 1; adult abdominal myoblast; external compound sense organ; antennal segment; abdominal ventral longitudinal muscle 3. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 370 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    Biological Process: larval somatic muscle development [IMP]
    regulation of transcription [IEA][ISS]
    Molecular Function: DNA binding [IEA]
    specific RNA polymerase II transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPESQCPQY GEVNQLGGVF VNGRPLPNAT RMRIVELARL GIRPCDISRQ LRVSHGCVSK  60
   61 ILARYHETGS ILPGAIGGSK PRVTTPKVVN YIRELKQRDP GIFAWEIRDR LLSEGICDKT 120
  121 NVPSVSSISR ILRNKLGSLG HQHTPGTVMG SGSSSGGGSV SSNGGQNNGT SASNNINLSN 180
  181 LGNPGGGPHH PHHHHHHQSA AAAASAHHVH AHAHAHAHLY NSIYQPYSAA AAYSMKTPCG 240
  241 SPSPPQGAGG QGSVPHPHQL RSVAAAAAAA HWPSSHSVSD ILAHHQAVAL RASCQVGVGV 300
  301 GGMGGMGSTV SPLPMTPSPV AGTAGGQPLL DCEGGAGQQS PYNYYMYFQN GGMHHHHHHG 360
  361 GMMAAGATGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] PSI-BLAST 56.045757 Pax-5
    2 View Details [159..256] PSI-BLAST 8.0 Paired protein
    3 View Details [257..370] FFAS03 1.12 Crystal structure of a hypothetical protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  2.10377840258047 bayes_pls_golite062009
  • binding
    		•  1.70581877784522 bayes_pls_golite062009
  • protein binding
    		•  1.35119799527292 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  1.08303391887125 bayes_pls_golite062009
  • catalytic activity
    		•  0.759273731741151 bayes_pls_golite062009
  • transferase activity
    		•  0.29748053214444 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  0.100848174559199 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.0951797097761462 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.0869374373560942 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle